H1F0
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Official Full Name
H1 histone family, member 0
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Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. -
Synonyms
H1F0; H1 histone family, member 0; H1FV; histone H1.0; H1.0; H1(0); H1 0; H10; H1 histone family member 0; Histone H1; Histone H10; Histone H5; MGC5241; histone H1(0); H1.0, H1(0), H1-0;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Thymus
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | H1F0-2132H | Recombinant Human H1 Histone Family, Member 0 | E.coli | N/A | ||
Human | H1F0-6945H | Recombinant Human H1F0 protein, His-tagged | E.coli | His | Met1-Lys194 | |
Human | H1F0-13640H | Recombinant Human H1F0, GST-tagged | E.coli | GST | 1-194a.a. | |
Human | H1F0-100H | Recombinant Human H1F0 Protein | E.coli | N/A | 1-194 | |
Human | H1F0-4528H | Recombinant Human H1F0 Protein, GST-tagged | Wheat Germ | GST | ||
Human | H1F0-2117HCL | Recombinant Human H1F0 cell lysate | N/A | |||
Human | H1F0-3395HF | Recombinant Full Length Human H1F0 Protein, GST-tagged | In Vitro Cell Free System | GST | 194 amino acids | |
Mouse | H1F0-7420M | Recombinant Mouse H1F0 Protein | Mammalian Cell | His | ||
Mouse | H1F0-4035M-B | Recombinant Mouse H1F0 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | H1F0-4035M | Recombinant Mouse H1F0 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | H1F0-2773R | Recombinant Rat H1F0 Protein | Mammalian Cell | His | ||
Rat | H1F0-2427R-B | Recombinant Rat H1F0 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | H1F0-2427R | Recombinant Rat H1F0 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bovine | H1F0-01B | Native Bovine H1F0 Protein | Thymus | 1-213 (H1.2), 1-221 (H1.3), and 1-219 (H1.4) | ||
Zebrafish | H1F0-9956Z | Recombinant Zebrafish H1F0 | Mammalian Cell | His | ||
Chicken | H1F0-3465C | Recombinant Chicken H1F0 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- H1F0 Related Articles
- H1F0 Related Research Area
H1F0 involved in several pathways and played different roles in them. We selected most pathways H1F0 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with H1F0 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of DNA fragmentation factor | HIST1H1A;HMGB2A;HMGB2;HIST1H1B;DFFA;HIST1H1E;H1F0;HIST1H1C;HIST1H1D |
Apoptosis | RIPK1L;DAPK1;IRAK2;Fasl;CTNNB2;CASP3A;RIPK1;PPP3R1B;CASP6L2 |
Apoptosis induced DNA fragmentation | DFFA;HIST1H1E;HIST1H1D;HIST1H1B;HIST1H1C;HMGB2;HIST1H1A;H1F0;HMGB2A |
Apoptotic execution phase | CASP6L1;DFFA;DBNLB;GAS2;CLSPN;STK26;HIST1H1A;PTBP3;HIST1H1C |
Cellular Senescence | CBX6;SUZ12B;PHC3;EHMT2;TXN;KDM6B;SUZ12;BMI1B;CBX4 |
Cellular responses to stress | PRDX3;PRDX2;H3F3B.1;RB1CC1;WDR45;POT1;C11orf73;WIPI1;KDM6B |
DNA Damage/Telomere Stress Induced Senescence | HMGA1;UBN1;TINF2;HIST1H1D;HIST1H1A;ASF1A;CABIN1;H1F0;HIRA |
Formation of Senescence-Associated Heterochromatin Foci (SAHF) | HIRA;EP400;HIST1H1C;HIST1H1E;ASF1A;CABIN1;HIST1H1D;HIST1H1B;HMGA1B |
H1F0 has several biochemical functions, for example, chromatin DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H1F0 itself. We selected most functions H1F0 had, and list some proteins which have the same functions with H1F0. You can find most of the proteins on our site.
Function | Related Protein |
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chromatin DNA binding | HIST1H1D;RXRA;AASS;CLOCK;NEUROG3;H2AFY;GRHL3;RELA;GRHL2 |
poly(A) RNA binding | COX4I2;HNRNPL;CCDC9;RBM47;CSTF1;RPGR;RBM39;HNRNPA0;RRP9 |
protein binding | MAGEB6;GRHL3;DNAI1;CKS1B;VIPAS39;RACGAP1;CAP2;MRFAP1;TFF2 |
H1F0 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H1F0 here. Most of them are supplied by our site. Hope this information will be useful for your research of H1F0.
RAD51B; E1; par; IKBKG; lt_sv40; GRB2; NOA1; 2_aha_camp; ssrna_cg
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that the expression level of H1F0 is associated with a variety of diseases. For example, in some cancers, the expression level of H1F0 is upregulated, which promotes the proliferation and metastasis of tumor cells. In some neurodegenerative diseases, the expression of H1F0 may be down-regulated, leading to cell death.
H1F0 has a complex relationship with other genes or proteins. For example, it interacts with some transcription factors and regulatory proteins of signal transduction pathways, affecting gene expression and cell signal transduction. In addition, H1F0 is also affected by some epigenetic modifications, such as methylation and acetylation.
In order to better understand the role of H1F0 in diseases, further in-depth research is needed on its specific mechanism of action and function. In addition, it is also necessary to study the changes in its expression level and activity in different diseases, as well as its relationship with the occurrence and development of diseases. At the same time, it is also necessary to explore the clinical application prospects and effects of the therapeutic strategies that regulate them.
H1F0 is mainly located in the nucleus, binds to chromatin (DNA-protein complex) and regulates its structure. It is able to influence the way DNA is folded and packaged, which in turn affects gene expression and DNA repair. In addition, H1F0 is also involved in the regulation of cell division and cell cycle.
There are still some limitations in the current research on H1F0, such as the lack of in-depth research on its specific mechanism and function, and the incomplete understanding of its relationship with diseases. In addition, since H1F0 is a multifunctional protein, regulating it may also have some side effects.
Therapeutic strategies for H1F0 include inhibiting its expression, modulating its activity, or using gene therapy. For example, some studies have shown that the use of small molecule inhibitors targeting H1F0 can inhibit its activity and thus treat some H1F0-related diseases. In addition, related diseases can also be treated by regulating the expression level of H1F0.
Customer Reviews (3)
Write a reviewH1F0 has good stability and long-term storage without problems.
Strong stability, can form a stable micelle structure.
It performs well in western blotting experiments.
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