| Official Full Name | H3 histone, family 3A |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008] |
| Synonyms | H3F3A; H3 histone, family 3A; H3F3; H3.3A; histone H3.3; H3-VIII; histone H3.2; Histone H3.1; FLJ92264; H3 histone; H3 histone family, member A; H3/a; H3/b; H3/c; H3/d; h3/f; H3/h; H3/i; H3/j; H3/k; H3/l; H31_HUMAN; H3F1K; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; Histone 1, H3a; Histone cluster 1, H3a; Histone cluster 1, H3b; Histone cluster 1, H3c; Histone cluster 1, H3d; Histone cluster 1, H3e; Histone cluster 1, H3f; Histone cluster 1, H3g; Histone cluster 1, H3i; Histone cluster 1, H3j; Histone H 3; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; histone H3 class I; H3-I; H3-V; H3-II; H3-IV; H3-VI; H3-III; H3-VII |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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H3F3A involved in several pathways and played different roles in them. We selected most pathways H3F3A participated on our site, such as Alcoholism, Transcriptional misregulation in cancer, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H3F3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | DRD1; GNG3; HIST1H3H; HIST1H2AD; MAPK3; HIST1H4C; CRH; HDAC1; HIST1H2BA; NPY |
| Transcriptional misregulation in cancer | RXRA; SIX1; BMI1; MEN1; PLAU; IGFBP3; IL6; CD14; PML; IL1R2 |
| Systemic lupus erythematosus | HIST1H3G; GM14476; GM14478; C5; HLA-DPB1; C8B; HIST1H4L; HIST1H3D; H2AFX; HIST1H4I |
H3F3A has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H3F3A itself. We selected most functions H3F3A had, and list some proteins which have the same functions with H3F3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter sequence-specific DNA binding | WBP2; RUVBL2; STAT6; SFPI1; GATA1; SOX11; NFIL3; NSD1; TAL1; TRP53 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | MEOX2; GATA2; MED12; BACH1; ATF2; GZF1; PBX3; NR5A2; BACH1A; CDX1 |
| histone binding | Ctsl; HIST2H4; HIST1H4C; HIST2H4A; ASF1A; APBB1; DAXX; RNF168; HIST2H3C1; ZMYND11 |
| nucleosomal DNA binding | HMGN1; HMGN5; HMGN2; H2AFY; NSBP1; H2AFZ; H3F3A; HNRNPC; H3F3B; H1FOO |
| protein binding | VPS52; GNG5; HOOK2; SH3GL1; HILPDA; DPM1; SRF; ACOT7; CLEC7A; L3MBTL1 |
| protein heterodimerization activity | H3F3A; CAPN2; Bcl2a1b; HIST3H3; MAFGA; SUPT4H1; ARNT2; TYR; SMC4; HIST1H2BK |
H3F3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H3F3A here. Most of them are supplied by our site. Hope this information will be useful for your research of H3F3A.
DNMT3A; PELP1; BPTF
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