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H3F3A

  • Official Full Name

    H3 histone, family 3A

  • Overview

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]
  • Synonyms

    H3F3A; H3 histone, family 3A; H3F3; H3.3A; histone H3.3; H3-VIII; histone H3.2; Histone H3.1; FLJ92264; H3 histone; H3 histone family, member A; H3/a; H3/b; H3/c; H3/d; h3/f; H3/h; H3/i; H3/j; H3/k; H3/l; H31_HUMAN; H3F1K; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; Histone 1, H3a; Histone cluster 1, H3a; Histone cluster 1, H3b; Histone cluster 1, H3c; Histone cluster 1, H3d; Histone cluster 1, H3e; Histone cluster 1, H3f; Histone cluster 1, H3g; Histone cluster 1, H3i; Histone cluster 1, H3j; Histone H 3; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; histone H3 class I; H3-I; H3-V; H3-II; H3-IV; H3-VI; H3-III; H3-VII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • HIS
  • SUMO
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human H3F3A-4542H Recombinant Human H3F3A Protein, GST-tagged Wheat Germ GST
Human H3F3A-102H Recombinant Human H3F3A Protein E.coli N/A 1-136
Human H3F3A-62H Recombinant Human H3F3A protein, T7/His-tagged E.coli T7/His
Human H3F3A-568H Recombinant Human H3 histone, family 3A, His-tagged E.coli His
Human H3F3A-116H Recombinant Human H3F3A Protein, HIS-tagged E.coli HIS
Human H3F3A-5654HCL Recombinant Human H3F3A 293 Cell Lysate HEK293 N/A
Human H3F3A-3014H Recombinant Human H3F3A protein, GST-tagged E.coli GST 2-136aa
Human H3F3A-3013H Recombinant Human H3F3A protein, His-SUMO-tagged E.coli His-SUMO 2-136aa
Human H3F3A-3410HF Recombinant Full Length Human H3F3A Protein, GST-tagged In Vitro Cell Free System GST 136 amino acids
Zebrafish H3F3A-12240Z Recombinant Zebrafish H3F3A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

H3F3A involved in several pathways and played different roles in them. We selected most pathways H3F3A participated on our site, such as Alcoholism, Transcriptional misregulation in cancer, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H3F3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismHIST1H2BK;CALML3;HDAC2;HIST1H4D;H3F3B;CAMK4;HIST1H2BD;GNAI3;H2BFWT
Transcriptional misregulation in cancerRXRB;FLI1;IL6;RARA;RXRG;CEBPE;SIN3A;PFTK1;ASPSCR1
Systemic lupus erythematosusHIST1H4B;C6;GM14479;SNRPD1;ACTN1;HIST2H2AA4;HIST3H2BB-PS;HLA-DRB3;HLA-DRA

H3F3A has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H3F3A itself. We selected most functions H3F3A had, and list some proteins which have the same functions with H3F3A. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingNLRC5;SMYD3;SFPI1;SOX11;FOS;GATA3;SP1;TRP53;WBP2
RNA polymerase II distal enhancer sequence-specific DNA bindingPAX4;REL;ARX;NR5A2;ESRRB;NFE2L1;H3F3A;T;ARID3B
histone bindingHIST2H4A;HIST1H47;PIH1D1;HIST1H4I;NAP1L2;CHAF1B;TONSL;ELP2;SET
nucleosomal DNA bindingH3F3A;HNRNPC;HMGN5;NSBP1;H3F3C;H1FOO;H2AFZ;HMGA2;H3F3B
protein bindingKCNG3;YRDC;ATXN7L3;HMGB2;IFNAR1;HUS1;ABCE1;C12orf49;CKB
protein heterodimerization activityCUL3;HIST1H4F;ERBB2;SCUBE1;H2AFVA;NFKB1;MAP3K7;TAS1R2;BNIP3

H3F3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H3F3A here. Most of them are supplied by our site. Hope this information will be useful for your research of H3F3A.

DNMT3A; PELP1; BPTF

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