HAND2 Protein, heart and neural crest derivatives expressed 2

HAND2

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HAND2

Official Full Name heart and neural crest derivatives expressed 2
Background The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
Synonyms HAND2; heart and neural crest derivatives expressed 2; heart- and neural crest derivatives-expressed protein 2; bHLHa26; dHand; Hed; Thing2; class A basic helix-loop-helix protein 26; basic helix-loop-helix transcription factor HAND2; deciduum, heart, aut
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HAND2-13663H Recombinant Human HAND2, GST-tagged E.coli GST
    Human HAND2-4568H Recombinant Human HAND2 Protein, GST-tagged Wheat Germ GST
    Mouse HAND2-7474M Recombinant Mouse HAND2 Protein Mammalian Cell His
    Rat HAND2-2787R Recombinant Rat HAND2 Protein Mammalian Cell His
    Rhesus Macaque HAND2-2034R Recombinant Rhesus monkey HAND2 Protein, His-tagged Mammalian Cell His
    Chicken HAND2-6525C Recombinant Chicken HAND2 Mammalian Cell His
    Zebrafish HAND2-9164Z Recombinant Zebrafish HAND2 Mammalian Cell His

    HAND2 involved in several pathways and played different roles in them. We selected most pathways HAND2 participated on our site, such as Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, Neuronal System, Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity MYO6; GRIP1; NSFA; NSFB; PICK1; HAND2; CACNG2; AKAP5; CACNG3
    Neuronal System GJC1; DLG1L; CHRNA5; KCNH6; PPFIA4; KCNK13B; HAND2; KCNK2; ARL6IP5B; KCNN1B
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell NCALDA; AKAP5; PICK1; GABRR2A; MYO6; CHRNE; HAND2; CHRND; NSFA; NSFB
    Trafficking of AMPA receptors PICK1; GRIP1; HAND2
    Trafficking of GluR2-containing AMPA receptors HAND2; PICK1; GRIP1
    Transmission across Chemical Synapses CAMKK1B; SLC6A1A; Apba1; CACFD1; DLG1L; CACNB4B; SYN2; SNAP25B; PICK1; CPLX2L

    HAND2 has several biochemical functions, for example, ATPase activity, Arp2/3 complex binding, G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAND2 itself. We selected most functions HAND2 had, and list some proteins which have the same functions with HAND2. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity HSP90AA1; PSMC3; WRN; PEX6; TOR1B; DNAHC8; CENPE; ABCD1; KIF7; ATP13A
    Arp2/3 complex binding WHAMM; GMFB; CORO1B; HAND2; ARPC2; SNX9; PICK1; GMFG
    G-protein coupled receptor binding GNAV1; GNAI2; GNAT3; INSL3; PSAP; STUB1; GNA11B; RSPO1; SAA1; HSPA1A
    actin filament binding GAS2L2; CORO1CA; ERMN; EZR; LASP1; FSCN1A; TNNC1; TLN1; MYH11A; DBNLB
    enzyme binding ARRB2; NPM2; UGT1A6; CDC20; CCDC99; IQCB1; GSTM1; CAT; MTA1; H2AFX
    identical protein binding CORO1B; THBS1; STK10; SLC2A1; TRIP13; ESR1; AIRE; BNIP2; SERPINB1A; CLPP
    metal ion binding KDM6A; ACACB; ZNF48; ZFP12; ZNF593; ZNF668; DNAJA4; NAALADL1; SPATA21; RFESD
    protein C-terminus binding CORO1A; CALCOCO1; VPS36; PEX12; SDC1; AP2A1; MED12; MIF4GD; ATF4; VGLL1
    protein binding USP37; ZHX3; FNTB; LURAP1; NME4; ACVR1B; KDM5A; GIPC2; HSF1; FANCF
    protein domain specific binding TACC1; NLRP1; EHD2; ARRB2; RAB27A; CNOT1; CBX3; RUNX2; TFDP2; KCNN2
    protein kinase C binding SQSTM1; GRK5; AKT2; HDAC5; NELL2; SDPRB; PRKCSH; GLRX3; SDC4; C1QBP
    receptor binding GLA; GSTM2; LTB; CTNND1; WNT4A; IFNL3; PTPRD; ARRB2; BAAT; CNPY4

    HAND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAND2.

    TCF4

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