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Official Full Name hydroxyacid oxidase 2 (long chain)
Background This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described.
Synonyms HAO2; hydroxyacid oxidase 2 (long chain); hydroxyacid oxidase 2; (S) 2 hydroxy acid oxidase; GIG16; glycolate oxidase; growth inhibiting protein 16; HAOX2; long chain L 2 hydroxy acid oxidase; peroxisomal; (S)-2-hydroxy-acid oxidase; 2 hydroxy acid oxidase peroxisomal; Cell growth-inhibiting gene 16 protein; HAO 2; HAOX2_HUMAN; Long chain alpha hydroxy acid oxidase; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase; growth-inhibiting protein 16; (S)-2-hydroxy-acid oxidase, peroxisomal
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HAO2-1515H Recombinant Human HAO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HAO2-2241H Recombinant Human HAO2 Protein (2-351 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse Hao2-3355M Recombinant Mouse Hao2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HAO2-5763H Recombinant Human HAO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HAO2-12H Recombinant Human HAO2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HAO2-13H Recombinant Human HAO2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HAO2-4572H Recombinant Human HAO2 Protein, GST-tagged Wheat Germ GST
    Human HAO2-5637HCL Recombinant Human HAO2 293 Cell Lysate HEK293 N/A
    Rat HAO2-2788R Recombinant Rat HAO2 Protein Mammalian Cell His
    Zebrafish HAO2-10781Z Recombinant Zebrafish HAO2 Mammalian Cell His

    HAO2 involved in several pathways and played different roles in them. We selected most pathways HAO2 participated on our site, such as Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glyoxylate and dicarboxylate metabolism GLDC; ACAT1; GCSHA; CS; CAT; MDH1; PCCB; GLULA; GLUL; MUT
    Metabolic pathways SDS; AKR1B1; DGKZ; PLA2G2E; IPMKB; PON3; GMPPAB; PIGQ; DBH; ACSL4A
    Carbon metabolism ackA; G6PD; ACO2; PFKP; PGK1; GOT2B; CPS1; PRPS2; GPI; CS

    HAO2 has several biochemical functions, for example, (S)-2-hydroxy-acid oxidase activity, FMN binding, long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAO2 itself. We selected most functions HAO2 had, and list some proteins which have the same functions with HAO2. You can find most of the proteins on our site.

    Function Related Protein
    (S)-2-hydroxy-acid oxidase activity HAO1; HAO2
    FMN binding HAO2; PNPO; NOS2B; POR; HAO1; CREG2; NOS1; NOS2; CREG1; NOS3
    long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity HAO2; HAO1
    medium-chain-(S)-2-hydroxy-acid oxidase activity HAO1; HAO2
    receptor binding SEMA4D; PEX14; IDH1; CROT; IL28A; ARPP19; Icosl; ENSA; GSTM2; GIPC1
    very-long-chain-(S)-2-hydroxy-acid oxidase activity HAO2; HAO1

    HAO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAO2.


    Barawkar, DA; Bandyopadhyay, A; et al. Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22:4341-4347(2012).
    Barawkar, DA; Meru, A; et al. Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats. ACS MEDICINAL CHEMISTRY LETTERS 2:919-923(2011).

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