hap1
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  • Official Full Name
  • huntingtin-associated protein 1
  • Background
  • Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified.
  • Synonyms
  • HAP1; huntingtin-associated protein 1; HAP2; hHLP1; HIP5; HLP; neuroan 1; HAP-1; huntingtin-associated protein 2
Cat.#:HAP1-4573HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HAP1 Protein, GST-tagged
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Cat.#:HAP1-1598HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HAP1 protein, His & GST-tagged
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Cat.#:HAP1-499HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HAP1
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Cat.#:Hap1-1599MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hap1 protein, His & T7-tagged
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Cat.#:Hap1-1600RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hap1 protein, His & GST-tagged
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Cat.#:HAP1-2789RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HAP1 Protein
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Involved Pathway

HAP1 involved in several pathways and played different roles in them. We selected most pathways HAP1 participated on our site, such as GABAergic synapse, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
GABAergic synapse
PRKACG; GNG12; GABRG3; GNG3; GABARAPL1; GNB3; GNB1; GABRR2; GNAI1; GNGT1
Huntingtons disease
TP53; PLCB4; COX7C; NDUFB9; NDUFA2; COX7A1; ATP5D; SLC25A5; UQCRH; DNAL4

Protein Function

HAP1 has several biochemical functions, for example, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAP1 itself. We selected most functions HAP1 had, and list some proteins which have the same functions with HAP1. You can find most of the proteins on our site.
Function
Related Protein
Function kinase binding
Related Protein PPP2R5A; CHP; CDC37; STUB1; ABI2; SP100; WWC2; HSP90AB1; PPP1R9B; MOB4

Interacting Protein

HAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAP1.
AHI1; HMOX2; RPS10; TAF1D; C8orf33; ATXN3; PSMD11; RER1; MGEA5

HAP1 Related Articles

Murray, GL; et al. The lipoprotein LipL32, an enigma of leptospiral biology. VETERINARY MICROBIOLOGY 162:305-314(2013).
Islam, MN; Fujinaga, R; et al. CHARACTERIZATION OF THE "SPORADICALLY LURKING HAP1-IMMUNOREACTIVE (SLH) CELLS" IN THE HIPPOCAMPUS, WITH SPECIAL REFERENCE TO THE EXPRESSION OF STEROID RECEPTORS, GABA, AND PROGENITOR CELL MARKERS. NEUROSCIENCE 210:67-81(2012).