hcn4
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  • Official Full Name
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • Background
  • The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated cation channel. HCN4 channels contribute to pacemaker currents in the heart and brain.
  • Synonyms
  • HCN4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; hyperpolarization activated cyclic nucleotide-gated cation channel 4; SSS2
Cat.#:HCN4-4630HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HCN4 Protein, GST-tagged
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Cat.#:HCN4-2809RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HCN4 Protein
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Involved Pathway

HCN4 involved in several pathways and played different roles in them. We selected most pathways HCN4 participated on our site, such as HCN channels, Neuronal System, Potassium Channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HCN channels
HCN4
Neuronal System
KCNB2; PPFIA2; KCNAB3; NSFB; KCNK2B; KCNV2; CACNB4B; SNAP25B; LIN7C; SLC6A12
Potassium Channels
KCNMA1; KCNK6; KCNK7; KCNJ1A.1; KCND3; ABCC9; KCNJ14; KCNH2A; KCNMB2; KCNJ1
cAMP signaling pathway
PPP1R12A; SOX9; PIK3R5; CREB5; ATP1B3; AKT2; HCAR3; GRIN2A; GRIA3; ARAP3

Protein Function

HCN4 has several biochemical functions, for example, cAMP binding, identical protein binding, intracellular cAMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCN4 itself. We selected most functions HCN4 had, and list some proteins which have the same functions with HCN4. You can find most of the proteins on our site.
Function
Related Protein
Function cAMP binding
Related Protein PDE3A; HCN2; PRKAR2B; CNMPD1; POPDC2; PDE4D; CNGA4; PDE11A; PDE4A; BVES
Function identical protein binding
Related Protein ALAD; CLDN8; DYNLT1B; TTN; CREBZF; BAIAP2; C14orf166; SNCAIP; CIDEB; MCM10
Function intracellular cAMP activated cation channel activity
Related Protein CNGA4; HCN2; CNGA3; CNGA5; CNGA1; HCN4
Function voltage-gated potassium channel activity
Related Protein KCNB2; KCNA6A; KCNC4; KCNH1B; KCNC1B; KCNH1A; KCNK9; KCNH6; KCNH2; KCNMA1
Function voltage-gated sodium channel activity
Related Protein SCN3B; PKD2; SCN3A; SCN8A; SCN11A; SCN12AA; SCN12AB; SCN8AA; SCN2A; SCN8AB

HCN4 Related Articles

Pauza, DH; Rysevaite, K; et al. Innervation of sinoatrial nodal cardiomyocytes in mouse. A combined approach using immunofluorescent and electron microscopy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 75:188-197(2014).
Newton, CM; Stoyek, MR; et al. Regional Innervation of the Heart in the Goldfish, Carassius auratus: A Confocal Microscopy Study. JOURNAL OF COMPARATIVE NEUROLOGY 522:456-478(2014).