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HCRTR2

  • Official Full Name

    hypocretin (orexin) receptor 2

  • Overview

    The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
  • Synonyms

    HCRTR2; hypocretin (orexin) receptor 2; orexin receptor type 2; OX2R; Hypocretin receptor 2; Hypocretin receptor type 2; Orexin receptor 2; Ox-2-R; Ox2-R; OX2R_HUMAN; OTTHUMP00000017762;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • 10His
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCRTR2-4636H Recombinant Human HCRTR2 Protein, GST-tagged Wheat Germ GST
Human HCRTR2-775HCL Recombinant Human HCRTR2 cell lysate N/A
Human HCRTR2-5424H Recombinant Human HCRTR2 protein, His-tagged Yeast His 1-75aa
Human HCRTR2-0772H Recombinant Human HCRTR2 Protein (K294-H388), Flag/10×His tagged Insect Cell Flag/10His K294-H388
Mouse HCRTR2-7524M Recombinant Mouse HCRTR2 Protein Mammalian Cell His
Mouse HCRTR2-4086M Recombinant Mouse HCRTR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HCRTR2-4086M-B Recombinant Mouse HCRTR2 Protein Pre-coupled Magnetic Beads HEK293
Rat HCRTR2-2812R Recombinant Rat HCRTR2 Protein Mammalian Cell His
Rat HCRTR2-2467R-B Recombinant Rat HCRTR2 Protein Pre-coupled Magnetic Beads HEK293
Rat HCRTR2-2467R Recombinant Rat HCRTR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canis lupus familiaris (Dog) (Canis familiaris) RFL29879CF Recombinant Full Length Dog Orexin Receptor Type 2(Hcrtr2) Protein, His-Tagged E.coli expression system His Full Length (1-444)
Mus musculus (Mouse) RFL9872MF Recombinant Full Length Mouse Orexin Receptor Type 2(Hcrtr2) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Rattus norvegicus (Rat) RFL25549RF Recombinant Full Length Rat Orexin Receptor Type 2(Hcrtr2) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Zebrafish HCRTR2-4905Z Recombinant Zebrafish HCRTR2 Mammalian Cell His
Chicken HCRTR2-2188C Recombinant Chicken HCRTR2 Mammalian Cell His
Kit-1341 HCRTR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1342 HCRTR2 Total GPCR Internalization Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HCRTR2 Related Gene Family
  • HCRTR2 Related Research Area

HCRTR2 involved in several pathways and played different roles in them. We selected most pathways HCRTR2 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCRTR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionRXFP1;TAAR14E;TAAR4;MCHR1;PTGER3;TSPO;TAAR1B;GRIN3A;GRIA3A

HCRTR2 has several biochemical functions, for example, neuropeptide receptor activity, orexin receptor activity, peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCRTR2 itself. We selected most functions HCRTR2 had, and list some proteins which have the same functions with HCRTR2. You can find most of the proteins on our site.

Function Related Protein
neuropeptide receptor activityNPFFR1;KISS1RA;PRLHR;NPFFR1L1;NPFFR1L2;NPSR1;HCRTR1;NMUR1;NPFFR1L3
orexin receptor activityHCRTR2;HCRTR1
peptide bindingCMA1;NPFFR1;AVPR2L;NUP98;NLN;ENPEP;THOP1;RPS6KB2;FNTB
peptide hormone bindingANXA5;AGTR1B;INHBA;GALR2;GHR;OXTR;GHRHR;CRHR2;AGTR2

HCRTR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCRTR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCRTR2.

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