• Official Full Name
  • HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
  • Background
  • HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).
  • Synonyms
  • HERC6; HECT and RLD domain containing E3 ubiquitin protein ligase family member 6; hect domain and RLD 6; probable E3 ubiquitin-protein ligase HERC6; FLJ20637; potential ubiquitin ligase; HECT domain and RCC1-like domain-containing protein 6
Source (Host):HEK293Species:Human
Product nameRecombinant Human HERC6 Protein, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HERC6 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HERC6, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HERC6 Protein

Protein Function

HERC6 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC6 itself. We selected most functions HERC6 had, and list some proteins which have the same functions with HERC6. You can find most of the proteins on our site.
Related Protein
Function ligase activity
Related Protein DZIP3; SIAH1A; RC3H2; TRIM37; ITCH; DTX2; TRIM39; TRIM9; NEURL1B; UHRF1
Function ubiquitin protein ligase activity
Related Protein RNF111; CDC34; PELI1; UBE2H; CMTM2A; RNF41; SIAH1A; HECW2; MYLIP; RAG2

Interacting Protein

HERC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC6.

HERC6 Related Articles

Marfell, BJ; O'Brien, R; et al. Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 40:210-217(2013).
Forde, N; Duffy, GB; et al. Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau. PHYSIOLOGICAL GENOMICS 44:799-810(2012).