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HERC6

  • Official Full Name

    HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

  • Overview

    HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).
  • Synonyms

    HERC6; HECT and RLD domain containing E3 ubiquitin protein ligase family member 6; hect domain and RLD 6; probable E3 ubiquitin-protein ligase HERC6; FLJ20637; potential ubiquitin ligase; HECT domain and RCC1-like domain-containing protein 6;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HERC6-13741H Recombinant Human HERC6, His-tagged E.coli His 11-98a.a.
Human HERC6-4694H Recombinant Human HERC6 Protein, GST-tagged Wheat Germ GST
Human HERC6-1093H Recombinant Human HERC6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse HERC6-7583M Recombinant Mouse HERC6 Protein Mammalian Cell His
Mouse HERC6-4129M Recombinant Mouse HERC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Herc6-3385M Recombinant Mouse Herc6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HERC6-4129M-B Recombinant Mouse HERC6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HERC6 Related Articles

HERC6 involved in several pathways and played different roles in them. We selected most pathways HERC6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

HERC6 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC6 itself. We selected most functions HERC6 had, and list some proteins which have the same functions with HERC6. You can find most of the proteins on our site.

Function Related Protein
ligase activityUHRF1;RNF187;RING1;TRIM68;PELI1;UBR7;ATG10;UBE2G1B;LNX1
ubiquitin protein ligase activityMSL2;UBE3B;RNF146;NEDD4;TRIM2;RNF126;RAG2;ARIH2;COP1

HERC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC6.

HSP90AB1

Marfell, BJ; O'Brien, R; et al. Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 40:210-217(2013).
Forde, N; Duffy, GB; et al. Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau. PHYSIOLOGICAL GENOMICS 44:799-810(2012).
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