Recombinant Human HERC6, His-tagged

• Cat.No.: HERC6-13741H
• Product Overview: Recombinant Human HERC6 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 11-98a.a.
• Description: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [ Homo sapiens ]
• Official Symbol: HERC6
• Synonyms: HERC6; HECT and RLD domain containing E3 ubiquitin protein ligase family member 6; hect domain and RLD 6; probable E3 ubiquitin-protein ligase HERC6; FLJ20637; potential ubiquitin ligase; HECT domain and RCC1-like domain-containing protein 6
• Gene ID: 55008
• mRNA Refseq: NM_001165136
• Protein Refseq: NP_001158608
• MIM: 609249
• UniProt ID: Q8IVU3
• Chromosome Location: 4q22
• Function: acid-amino acid ligase activity; ligase activity; ubiquitin-protein ligase activity