hesx1
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  • Official Full Name
  • HESX homeobox 1
  • Background
  • This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
  • Synonyms
  • HESX1; HESX homeobox 1; homeobox, ES cell expressed 1; homeobox expressed in ES cells 1; ANF; RPX; hAnf; homeobox protein ANF; Rathke pouch homeobox; CPHD5
Cat.#:HESX1-4708HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HESX1 Protein, GST-tagged
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Cat.#:HESX1-13749HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HESX1, GST-tagged
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Cat.#:HESX1-7592MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HESX1 Protein
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Cat.#:HESX1-6570CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HESX1
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Cat.#:HESX1-8932ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HESX1
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Cat.#:HESX1-5579HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HESX1 293 Cell Lysate
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Involved Pathway

HESX1 involved in several pathways and played different roles in them. We selected most pathways HESX1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HESX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
WNT4; NANOG; WNT9A; MAP2K2; STAT3; ID3; ID4; PCGF1; WNT11; MAPK12

Protein Function

HESX1 has several biochemical functions, for example, DNA binding, chromatin binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HESX1 itself. We selected most functions HESX1 had, and list some proteins which have the same functions with HESX1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein BLZF1; HIST1H2BD; THAP10; SPRTN; MTERFD1; HIST1H4C; ZZZ3; TXLNB; HIST1H2B5; HBP1
Function chromatin binding
Related Protein CDCA5; KLHDC3; ZEB1; KLF6A; TOX4; HMGB3A; GATA6; REST; NOC2L; TOP2B
Function protein C-terminus binding
Related Protein SLC4A1; ABL1; STIP1; DDX1; TOP2B; HIC2; PICK1; DLG1; SCLT1; AXIN1
Function protein N-terminus binding
Related Protein VPS25; MORF4L1; SUV39H1; PEX14; PDCD10; TAF11; NCOR2; STXBP1; SYNGR3; ZWINT
Function protein binding
Related Protein CCDC112; CCDC25; HYLS1; NMU; GNGT1; NECAB3; BOLL; ATXN7; MRFAP1L1; ADCYAP1
Function sequence-specific DNA binding
Related Protein HOXC13; PRRX1A; HOXC13B; ISL2B; POU3F2B; FOXG1A; ATF4B1; GZF1; LMX1BB; TA

Interacting Protein

HESX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HESX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HESX1.
KDM1A; PRMT6; STAT3; STAT3

HESX1 Related Articles

Castinetti, F; Reynaud, R; et al. Combined pituitary hormone deficiency: current and future status. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 38:1-12(2015).
Takagi, M; Ishii, T; et al. A novel mutation in SOX3 polyalanine tract: a case of kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3. PITUITARY 17:569-574(2014).