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HESX1

  • Official Full Name

    HESX homeobox 1

  • Overview

    This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
  • Synonyms

    HESX1; HESX homeobox 1; homeobox, ES cell expressed 1; homeobox expressed in ES cells 1; ANF; RPX; hAnf; homeobox protein ANF; Rathke pouch homeobox; CPHD5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HESX1-4708H Recombinant Human HESX1 Protein, GST-tagged Wheat Germ GST
Human HESX1-13749H Recombinant Human HESX1, GST-tagged E.coli GST 1-185a.a.
Human HESX1-5579HCL Recombinant Human HESX1 293 Cell Lysate HEK293 N/A
Human HESX1-3522HF Recombinant Full Length Human HESX1 Protein, GST-tagged In Vitro Cell Free System GST 185 amino acids
Human HESX1-4583H Recombinant Human HESX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HESX1-2449H Recombinant Human HESX1 protein, His-tagged E.coli His 1-185 aa
Mouse HESX1-7592M Recombinant Mouse HESX1 Protein Mammalian Cell His
Mouse Hesx1-1115M Recombinant Mouse Hesx1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HESX1-4137M Recombinant Mouse HESX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HESX1-4137M-B Recombinant Mouse HESX1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HESX1-8932Z Recombinant Zebrafish HESX1 Mammalian Cell His
Chicken HESX1-6570C Recombinant Chicken HESX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HESX1 Related Articles

HESX1 involved in several pathways and played different roles in them. We selected most pathways HESX1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HESX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsWNT7B;WNT9A;WNT5B;ID3;GRB2;ACVR2A;MEIS1;ZIC3;SKIL

HESX1 has several biochemical functions, for example, DNA binding, chromatin binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HESX1 itself. We selected most functions HESX1 had, and list some proteins which have the same functions with HESX1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF483;MKXA;SIX3B;TAF1L;ZFP287;KDM5C;MEIS2A;NKX3.3;ZNF574
chromatin bindingPOLE;HIF1AB;POLD1;BRD4;YAP1;BRD3;RBPJ;EED;YBX1
protein C-terminus bindingKSR1;SNX17;PPP2CA;IFT52;PHB2;SREBF2;VTA1;MLLT4;ERCC3
protein N-terminus bindingRELA;SLA2;TSC1;SLC6A3;CSNK2A2;EIF5A;SCT;RASSF1;PDLIM5
protein bindingAZU1;AVPR2;NOS1;SYVN1;TKT;MYBL2;RBM8A;VIP;RAI2
sequence-specific DNA bindingISL1L;ZKSCAN3;HDAC2;EVX2;PKNOX1.1;CREB5;HOXC8A;UNCX4.1;E2F5

HESX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HESX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HESX1.

KDM1A; PRMT6; STAT3; STAT3

Castinetti, F; Reynaud, R; et al. Combined pituitary hormone deficiency: current and future status. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 38:1-12(2015).
Takagi, M; Ishii, T; et al. A novel mutation in SOX3 polyalanine tract: a case of kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3. PITUITARY 17:569-574(2014).
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