|Official Full Name||histone cluster 4, H4|
|Background||Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]|
|Synonyms||HIST4H4; histone cluster 4, H4; H4/p; histone H4; histone 4, H4;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HIST4H4 involved in several pathways and played different roles in them. We selected most pathways HIST4H4 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Alcoholism, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST4H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3||HIST3H2BB; KDM4C; KDM1A; HIST2H3C; NCOA2; HIST4H4|
|Alcoholism||CREB5; H2AFB3; CREB3; HIST1H4H; HDAC11; GNG8; HIST1H2AE; HIST1H3I; HIST1H2BG; HIST1H2BP|
|Amyloid formation||TGFBI; HIST4H4; SAA1; RHBDL1; TTR; APCS; NAT8B; ODAM; CEACAM21; MFGE8|
|Cell Cycle||GSK3AA; DCTN1; TBC1D8; CDKN1B; LEMD3; E2F6; TUBGCP4; NIPBL; GINS2; TRP53|
|Cell Cycle Checkpoints||CDK2; TP53BP1; HIST4H4; FAM175A; CDKN1B; RAD9B; DBF4; RAD9A; UIMC1; HTATIP|
|Cell Cycle, Mitotic||TMEM188; CENPE; ARPP19B; LMNB1; SDCCAG8; ANKLE2; NDEL1B; KIF20A; DCTN2; HIST4H4|
|Cellular Senescence||HIST1H1A; SUZ12A; RING1; H1F0; E2F2; CDKN2D; TERF2; CEBPB; AGO3; KAT5|
|Cellular responses to stress||TNIK; HIST1H1D; HIF1AN; ST13; BMI1B; HSPA7; Txn1; UBN1; HSPA12B; DYNLL2A|
HIST4H4 has several biochemical functions, for example, DNA binding, histone binding, histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST4H4 itself. We selected most functions HIST4H4 had, and list some proteins which have the same functions with HIST4H4. You can find most of the proteins on our site.
|DNA binding||FOSL1A; TOP3A; IRF7; MIER1B; NR5A2; ZFP41; AHRRB; EEF1D; CIC; PAX8|
|histone binding||CTSL2; WDTC1; SMARCA2; Ctsl; HJURP; SART3; SUPT6H; HINFP; MYSM1; NOC2L|
|histone demethylase activity (H4-K20 specific)||PHF8; HIST1H4L; HIST1H4F; HIST1H4K; HIST1H4E; JHDM1D; HIST1H4B; HIST4H4; HIST2H4A; HIST1H4H|
|poly(A) RNA binding||NME1; PPIB; PPHLN1; HDGF; RBM28; EIF4G3; HSP90AA1; APEX1; PRPF40A; SLIRP|
|protein binding||CARTPT; COPS5; TIRAP; MXD1; RSG1; NEUROG3; DSTN; PALB2; NDOR1; FAM212A|
|protein domain specific binding||YWHABL; HIST1H4C; HNRNPM; RAP2B; THRA; TJP1; ARFIP2A; YWHAQ; IST1; IRS2|
|protein heterodimerization activity||SYT10; SNX6; SMC3; HAND1; TYRO3; BDKRB2; HIST1H4F; TAS1R2; HIST1H2AL; RALGAPA1|
HIST4H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST4H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST4H4.
KDM4A; TP53BP1; SETD8