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HIST4H4

  • Official Full Name

    histone cluster 4, H4

  • Overview

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]
  • Synonyms

    HIST4H4; histone cluster 4, H4; H4/p; histone H4; histone 4, H4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIST4H4-401H Recombinant Human HIST4H4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HIST4H4-490H Recombinant Human HIST4H4 protein E.coli N/A
Human HIST4H4-4819H Recombinant Human HIST4H4 Protein, GST-tagged Wheat Germ GST
Human HIST4H4-29325TH Recombinant Human HisT4H4, His-tagged Wheat Germ His 103 amino acids
Human HIST4H4-5510HCL Recombinant Human HIST4H4 293 Cell Lysate HEK293 N/A
Human HIST4H4-229HF Recombinant Full Length Human HisT4H4 Protein, His-tagged In Vitro Cell Free System His 103 amino acids
Human HIST4H4-3607HF Recombinant Full Length Human HIST4H4 Protein, GST-tagged In Vitro Cell Free System GST 103 amino acids
Mouse Hist4h4-372M Recombinant Mouse Hist4h4 Protein, His-tagged E.coli His Ser2~Gly103
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HIST4H4 Related Research Area

HIST4H4 involved in several pathways and played different roles in them. We selected most pathways HIST4H4 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Alcoholism, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST4H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3KDM1A;HIST2H3C;NCOA2;KDM4C;HIST3H2BB;HIST4H4
AlcoholismHIST1H4H;GRB2;HIST3H2A;H2AFX;SHC3;HIST1H4L;SHC2;NPY;SHC1
Amyloid formationHIST3H2BB;RHBDL1;CEACAM21;MFGE8;TGFBI;CST3;ODAM;TTR;SAA1
Cell CycleCEP76;CTDNEP1B;CSNK2B;TP53;CDC27;CENPP;NUF2;GSK3B;LIN52
Cell Cycle CheckpointsCDK2;HTATIP;CHEK2;RAD17;YWHAQ;RAD9;UIMC1;RNF168;KAT5
Cell Cycle, MitoticMAPRE1A;GORASP1;LMNB1;GMNN;KIF2A;VRK2;MYCA;CKAP5;GINS2
Cellular SenescenceHIST4H4;RAD50;TERF2;AGO1;Txn1;SCMH1;EED;RING1;UBN1
Cellular responses to stressPRDX2;SCMH1;MOV10;MAPKAPK2B;BAG3;CDK6;AMBRA1B;HIRA;GABARAPL2

HIST4H4 has several biochemical functions, for example, DNA binding, histone binding, histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST4H4 itself. We selected most functions HIST4H4 had, and list some proteins which have the same functions with HIST4H4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFP90;XRCC5;TFDP2;TOX4;EOMESB;BHLHE41;RECQL;RIMKLB;NR4A3
histone bindingHIST1H4F;HIST1H4L;NAP1L2;HIST1H4M;SMARCA2;PKN1;ELP2;HIST1H3G;RAG1
histone demethylase activity (H4-K20 specific)HIST1H4F;HIST1H4J;PHF8;HIST1H4C;HIST1H4A;HIST1H4B;HIST4H4;HIST1H4H;HIST1H4I
poly(A) RNA bindingEIF4A3;SRRT;RPS19BP1;LIN28B;PHF5A;RPL29;LTA4H;CPEB2;PURG
protein bindingHOXA1;CBFA2T3;NDE1;PDCD2;SF3A3;ABI3;MYL2;CACNB4;CARD9
protein domain specific bindingHIST1H4B;YWHAQB;AIDA;GABRR1;YWHAQA;EHD2;RXRA;KPNB1;FAF1
protein heterodimerization activityPOU5F3;HIST2H2L;SYCP3;MCL1;BIRC5;RAF1;HIST2H2AC;PPARD;AGTR1

HIST4H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST4H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST4H4.

KDM4A; TP53BP1; SETD8

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