HLA-C

  • Official Full Name

    HLA-C major histocompatibility complex, class I, C [ Homo sapiens ]

  • Overview

    HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

  • Synonyms

    major histocompatibility complex, class I, C;4933;Ensembl:ENSG00000204525;FLJ27082;HLA class I histocompatibility antigen, Cw-1 alpha chain;MHC class I antigen heavy chain HLA-C;human leukocyte antigen-C alpha chain;major histocompatibility antigen HLA-C;HLA class I histocompatibility antigen, C alpha chain;HLC-C;D6S204;PSORS1;HLA-JY3
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-C-268H Recombinant Human major histocompatibility complex, class I, C, His-tagged E.coli Human His 25-308 a.a.
HLA-C-5498HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-C-242H Recombinant Human HLA-C Protein, His-tagged E.coli Human His Ser48~Thr305
HLA-C-269H Recombinant Human HLA-C protein, His-tagged HEK293 Human His
HLA-C-3560HF Recombinant Full Length Human HLA-C Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 336 amino acids

    Involved Pathway

    HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis FAM125A,PARD6GA,EHD1A,SH3GL1B,MHC1UEA,BC2,DNM2A,VPS36,ACAP1,ARR3A
    Phagosome ATP6V0C,MHC2DCB,RAB5C,CD209A,CTSLA,ATP6V0E2,TUBA4A,ATP6V1E1B,TUBA1C,MRC1
    Type I diabetes mellitus HLA-DQB1,CD80,HLA-DRB1,FAS,HLA-DRB3,PTPRN2,IFNG,Fasl,PTPRN,INS
    Antigen processing and presentation KIR2DS2,HLA-DRB4,TAP1,KIR2DS5,KIR3DL2,HSPA4,RFXANK,CTSB,CD8B,H2-AB1
    Natural killer cell mediated cytotoxicity TNFRSF10B,PTK2B,IFNA14,KLRC4-KLRK1,PPP3CA,ICAM1,IFNA21,SYK,ICAM2,ARAF
    Viral carcinogenesis GTF2H1,SCIN,RANBP1,EP300,IRF3,NFKB1,CASP8,HIST2H4,HIST1H4K,EIF2AK2
    Herpes simplex infection TRP53,EIF2AK1,IFN-a,SRSF6B,NFKBIAA,TAP2,TLR2-1,TAF4B,EIF2AK3,MAPK8A
    Viral myocarditis SGCD,CAV1,Casp3,RAC2,BID,CD40,EIF4G3,HLA-DRB3,EIF4G2,HLA-DPA1
    Allograft rejection HLA-DQB1,HLA-DRA,IL12A,FAS,CD28,HLA-DMB,IL12B,HLA-DRB5,HLA-DPA1,PRF1

    Protein Function

    HLA-C has several biochemical functions, for example, TAP binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.

    Function Related Protein
    TAP binding HLA-A,H2-Q10,HLA-B
    peptide antigen binding MHC1UXA2,H2-AA,HLA-F,MHC1ZKA,HLA-DQB1,MAML1,HLA-DRB3,HLA-E,MHC1UJA,HLA-DQA1

    Interacting Protein

    HLA-C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-C here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-C.

    Resources

    Gene Families

    Research Area

    References

    • Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).
    • Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).

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