hla-c
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  • Official Full Name
  • HLA-C major histocompatibility complex, class I, C [ Homo sapiens ]
  • Background
  • HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
  • Synonyms
  • major histocompatibility complex, class I, C; 4933; Ensembl:ENSG00000204525; FLJ27082; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; HLA class I histocompatibility antigen, C alpha chain; HLC-C; D6S204; PSORS1; HLA-JY3
Cat.#:HLA-C-242HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-C Protein, His-tagged
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Cat.#:HLA-C-4834HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HLA-C Protein, GST-tagged
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Cat.#:HLA-C-13811HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-C, GST-tagged
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Cat.#:HLA-C-268HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human major histocompatibility complex, class I, C, His-tagged
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Cat.#:HLA-C-5498HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HLA 293 Cell Lysate
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Involved Pathway

HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
GRK1B; RAB11BB; ASAP2A; ZFP652; CXCR2; KITA; TSG101; ARPC5LB; PDGFRA; ARAP1
Phagosome
SFTPD; RILP; RAB5AA; CTSLA; ATP6V0CB; TUBB1; SCARB1; TUBB5; TUBA7L; TUBA1L
Cell adhesion molecules (CAMs)
HLA-DRB5; CDH15; OCLNA; CTLA4; CDH4; CADM1A; CDH3; CADM3; NCAM1A; CD8B
Antigen processing and presentation
CD8B; B2M; HLA-DQB1; HLA-DQA2; HLA-DRB1; HLA-DOA; KLRC2; HSPA1B; HLA-DRA; NFYC
Natural killer cell mediated cytotoxicity
IFNAR1; Ifna11; LAT; H60a; IFNA16; ITGB2; IFNGR2; KIR2DL1; Fasl; VAV3
Type I diabetes mellitus
CPE; IL1A; HLA-DRB5; IL12A; CD86; H2-AB1; GAD1; H2-Q10; HLA-DRB3; PRF1
HTLV-I infection
IL15RA; POLD4; ANAPC7; MYBL1; MAP3K14; VCAM1; POLE; CD3E; CD3D; WNT1; HLA-DQB1
Herpes simplex infection
CFP; TAB2; FOS; HLA-DQA1; LOC100033925; MAPK9; CCL5; HLA-A; HLA-DPB1; MHC2A
Epstein-Barr virus infection
FCER2; AKT2; POLR2J2; HLA-DRB5; HLA-DQA1; HSPA1B; MAP2K4; HLA-DPA1; PIK3R3; TBPL1
Viral carcinogenesis
HPN; EP300; HIST1H4H; ACTN2; KRAS; MDM2; PXN; GTF2E2; PIK3CA; GTF2A1L
Autoi
HLA-DPB1; HLA-DPA1; TPO; IFNA8; HLA-DQA2; H2-AB1; IFNA5; HLA-DRB1; HLA-DOB; IL5
ne thyroid disease
HLA-C; IL4; IFNA14; Ifna15; IFNA4; TG; HLA-DMB; HLA-DRB5; GZMB; IFNA16
Allograft rejection
HLA-DOB; CD86; HLA-DRB5; TNF; CD40; HLA-DPA1; HLA-DQA1; HLA-DQB1; IL5; CD40LG
Graft-versus-host disease
GZMB; HLA-DRB5; FASLG; H2-Q10; PRF1; HLA-A; KIR3DL1; KIR2DL3; FAS; IL1B
Viral myocarditis
CD40LG; HLA-A; SGCG; CD86; RAC1; MYH7; HLA-G; HLA-DRB1; HLA-DQB1; HLA-DRA

Protein Function

HLA-C has several biochemical functions, for example, TAP binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.
Function
Related Protein
Function TAP binding
Related Protein HLA-A; H2-Q10; HLA-C; HLA-B
Function peptide antigen binding
Related Protein HLA-DRB3; H2-AA; MHC1UBA; MHC1UEA; CD209; MHC1UJA; CLEC4M; MHC1ZE; MHC1UFA; MHC1ZBA

HLA-C Related Articles

Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).
Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).

HLA-C Related Gene Family

Immunoglobulins