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HLA-C

  • Official Full Name

    HLA-C major histocompatibility complex, class I, C [ Homo sapiens ]

  • Overview

    HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
  • Synonyms

    major histocompatibility complex, class I, C; 4933; Ensembl:ENSG00000204525; FLJ27082; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; HLA class I histocompatibility antigen, C alpha chain; HLC-C; D6S204; PSORS1; HLA-JY3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-C-4834H Recombinant Human HLA-C Protein, GST-tagged Wheat Germ GST
Human HLA-C-13811H Recombinant Human HLA-C, GST-tagged E.coli GST 28-306a.a.
Human HLA-C-268H Recombinant Human major histocompatibility complex, class I, C, His-tagged E.coli His
Human HLA-C-5498HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-C-2940H Recombinant Human HLA-C Protein (Ser48-Thr305), His tagged E.coli His Ser48-Thr305
Human HLA-C-269H Recombinant Human HLA-C protein, His-tagged HEK293 His
Human HLA-C-242H Recombinant Human HLA-C Protein, His-tagged E.coli His Ser48~Thr305
Human HLA-C-3560HF Recombinant Full Length Human HLA-C Protein, GST-tagged In Vitro Cell Free System GST 336 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-C Related Articles
  • HLA-C Related Gene Family
  • HLA-C Related Research Area

HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisRAB10;CXCR4A;RAB11AL;HSPA1B;CBLB;IL2RG;VPS28;IGF1RB;ZFP652
PhagosomeHLA-DQA2;TUBA3C;HLA-DRB4;ATP6V0A1;TUBA1L;SEC61A1;THBS3A;THBS4B;SFTPA1
Cell adhesion molecules (CAMs)HLA-DRB5;HLA-DMA;CADM1;PRPSAP2;NLGN4A;CD58;CLDN18;LRRC4C;PDCD1LG2
Antigen processing and presentationTAP2;B2M;HLA-C;HLA-DMB;HLA-DRB3;NFYB;CANX;TNF;HLA-DPA1
Natural killer cell mediated cytotoxicityMAPK3;IFNA4;NCR3;MICB;ARAF;RAC3;IFNG;PRF1;FAS
Type I diabetes mellitusHLA-A;HLA-DQB1;TNF;IL1B;GAD2;HSPD1;H2-AA;CD28;HLA-B
HTLV-I infectionTBPL2;HLA-DRB1;POLE;PIK3CA;LCK;VCAM1;IL1R1;RAN;WNT16
Herpes simplex infectionSRPK1;ALYREF;HLA-DPA1;NFKBIA;TYK2;H2-AB1;IFNA7;HNRPK;NFKBIAA
Epstein-Barr virus infectionPOLR2J;NFKB1;PSMD13;PSMC3;HLA-C;TBPL2;CD38;YWHAE;IKBKG
Viral carcinogenesisVDAC3;CCNA1;STAT5B;PSMC1;CDC42;HNRNPK;KAT2B;CCNE2;CCNE1
AutoiHLA-A;Ifna15;HLA-DQB1;PRF1;TG;IFNA7;IFNA12;IFNA8;IFNA1
ne thyroid diseaseFasl;HLA-DRA;HLA-DRB5;Ifna11;IFNA7;CD40;HLA-F;HLA-E;HLA-DPA1
Allograft rejectionHLA-DRA;TNF;CD80;HLA-DPA1;H2-AA;HLA-C;HLA-DRB3;CD40;PRF1
Graft-versus-host diseaseHLA-DOA;CD80;IL1A;KIR3DL1;IFNG;HLA-DQA2;KIR2DL1;IL1B;GZMB
Viral myocarditisHLA-F;CD40LG;LAMA2;HLA-DQA1;HLA-DPB1;CASP8;HLA-B;EIF4G3;CASP9

HLA-C has several biochemical functions, for example, TAP binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.

Function Related Protein
TAP bindingHLA-A;H2-Q10;HLA-C;HLA-B
peptide antigen bindingHLA-DQB1;MHC1ZBA;CD209;MHC1ZFA;HLA-DQA1;MHC1UBA;MHC1UHA;TAP1;HLA-A

HLA-C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-C here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-C.

Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).
Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).
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