hla-dra
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  • Official Full Name
  • major histocompatibility complex, class II, DR alpha
  • Background
  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
  • Synonyms
  • MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12
Cat.#:HLA-DRA-353HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-DRA Protein, His-tagged
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Cat.#:HLA-DRA-490HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human major histocompatibility complex, class II, DR alpha, His-tagged
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Cat.#:HLA-DRA-5501HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HLA 293 Cell Lysate
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Involved Pathway

HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
CD209C; HLA-DPB1; ATP6V0E1; HLA-DRA; ATP6V0A1B; CTSSA; HLA-DOB; SCARB1; MHC1UXA2; CALRL2
Cell adhesion molecules (CAMs)
NLGN2B; ICAM3; NEO1A; BMA1; HLA-DMB; CLDNE; VCAM1; CD4; CLDN16; Ntng2
Antigen processing and presentation
HLA-DRB1; HLA-DQA1; Ctsl; NFYA; H2-AA; HSP90AB1; HLA-G; HSPA1L; CD8A; HLA-DMB
Hematopoietic cell lineage
CD3D; FCER2; ANPEP; IL6R; Kitl; CD9; CD3E; FCGR1A; IL9R; ITGAM
Intestinal i
IL4; CD40; BLB1; HLA-DRB4; TGFB1A; MADCAM1; CD28; CCL25B; ITGA4; HLA-DQA2
ne network for IgA production
BLB1; AICDA; MHC2DEB; BMA2; HLA-DPA1; MHC2DCB; CCR10; IL6; CD40; MHC2A
Type I diabetes mellitus
H2-Q10; PRF1; Fasl; TNF; IL12A; INS1; HLA-DQA2; PTPRN2; HLA-DRB4; HLA-DRB1
Leishmaniasis
FCGR2A; HLA-DQB1; IRAK1; IFNGR2; RELA; TRAF6; IL12B; ITGB2; NOS2; MARCKSL1
Toxoplasmosis
NFKBIB; TGFB2; AKT2; LAMC1; PIK3R3; LDLR; HSPA2; H2-AA; TAB2; HLA-DPA1
Staphylococcus aureus infection
HLA-DMA; HLA-DPB1; MBL1; C3AR1; DSG1A; FCGR2A; SELPLG; HLA-DQA2; ITGAL; C1S
Tuberculosis
CYCS; IL10RA; IL1B; MAPK8; MAPK11; CAMP; IL23; Cd209g; EEA1; CALM3
Influenza A
PRKCA; IL12A; RAF1; Ccl12; MAPK8; PABPN1L; HLA-DPA1; PIK3CB; IRF9; HLA-DRA
HTLV-I infection
PIK3R3; WNT9A; PPP3CA; ATM; PDGFB; KRAS; MAP3K14; SLC25A6; APC; CDC27
Herpes simplex infection
PER1A; TRAF6; HLA-E; CUL1B; CSNK2A2; IFNA1; Casp3; TAF4B; SRSF1B; HLA-A
Epstein-Barr virus infection
MAPK11; EIF2AK2; CD44; SND1; SNW1; Fcer2a; TBK1; ITGAL; DDX58; CR2
Asthma
CCL11; HLA-DQA2; HLA-DRB3; EPX; TNF; HLA-DPA1; IL4; MS4A2; H2-AB1; CD40
Autoi
IL4; H2-AB1; FASLG; IFNA5; TG; CD28; HLA-DPA1; HLA-DRA; IFNA6; HLA-DOB
ne thyroid disease
HLA-C; IFNA16; TG; HLA-DOB; GZMB; IFNA1; HLA-F; CD86; HLA-A; CD40
Inflammatory bowel disease (IBD)
NFATC1; STAT4; HLA-DRB1; IL12A; IL17A; SMAD2; HLA-DRB3; FOXP3; NFKB1; RORA
Systemic lupus erythematosus
HIST1H2AN; C8B; C6; HIST1H2AB; HIST1H4H; HIST1H2AE; HLA-DQA1; H2AFV; H2AFB3; HIST1H3F
Rheumatoid arthritis
FLT1; HLA-DQA1; TNFSF11; ATP6V1B2; ATP6V1D; ATP6V1C1; CXCL12; CXCL5; Il23a; CXCL1
Allograft rejection
Fasl; HLA-DRB5; HLA-DPB1; CD80; HLA-C; HLA-E; FASLG; GZMB; HLA-DQA1; PRF1
Graft-versus-host disease
Il2; HLA-DRB4; CD86; HLA-DRB3; KLRD1; IL1A; HLA-DRB1; HLA-B; KIR3DL2; HLA-DPA1
Viral myocarditis
CD80; CYCS; FYN; SGCB; ACTB; BID; CASP8; HLA-B; ITGAL; HLA-DPA1

Protein Function

HLA-DRA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein complex binding
Related Protein MS4A1; HSP90AB1; PKM2; CD74; PKM; ANXA11; HLA-DRA; HLA-DOB; HSPA8; ATP1B1
Function MHC class II receptor activity
Related Protein HLA-DQB2; HLA-DRB1; KRT17; HLA-DQB1; HLA-DRB3; HLA-DRA; HLA-DRB4; HLA-DQA2; HLA-DQA1; HLA-DPA1
Function peptide antigen binding
Related Protein TAP1; HLA-F; BF2; MHC1ZHA; MHC1UHA; TUBB3; MHC1UJA; HLA-DRB5; HLA-DQB1; MHC1UBA

Interacting Protein

HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.
HLA-DRB1; HLA-DRB1; HLA-DMA

HLA-DRA Related Articles

Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).