Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

HLA-DRA

  • Official Full Name

    major histocompatibility complex, class II, DR alpha

  • Overview

    HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
  • Synonyms

    MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E. coli
  • E.coli
  • HEK293
  • Yeast
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DRA-490H Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged E.coli His
Human HLA-DRA-5501HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DRA-5321H Recombinant Human HLA-DRA protein, His-tagged E.coli His 28-254aa
Human HLA-DRA-353H Recombinant Human HLA-DRA Protein, His-tagged E.coli His Lys27~Glu216
Human HLA-DRA-2300H Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged Yeast His 26-254 aa
Human HLA-DRA-231H Recombinant Human HLA-DRA protein, GST-tagged E. coli GST 24-218 aa
Human HLA-DRA-3571H Recombinant Human HLA-DRA Protein (Lys27-Glu216), His tagged E.coli His Lys27-Glu216
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DRA Related Articles
  • HLA-DRA Related Research Area

HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeEEA1;NCF1;RAC1;BLA;Cd209g;ATP6V0C;CALR;TAP2;MRC2
Cell adhesion molecules (CAMs)HLA-DOB;CNTN1A;PVRL2;ICOS;BMA2;ITGA6B;ITGA4;CADM3;ITGA6
Antigen processing and presentationNFYB;NFYC;KIR2DL1;KLRC3;HLA-DRB1;LGMN;PSME2;KIR3DL2;HSPA1B
Hematopoietic cell lineageTNF;IL11RA2;GYPA;HLA-DRB1;FCGR1A;CR1;EPOR;IL5;CD1D2
Intestinal iBLA;IL4;CCR10;HLA-DMB;HLA-DOB;HLA-DQA1;MHC2A;CD28;CD40LG
ne network for IgA productionTNFRSF17;CXCR4A;HLA-DPB1;CD86;HLA-DRA;HLA-DQA1;H2-AA;CCR10;CXCL12
Type I diabetes mellitusINS;HLA-DPB1;HLA-DQB1;HLA-B;H2-AA;HLA-DOB;HSPD1;FASLG;HLA-DPA1
LeishmaniasisHLA-DOA;PTPN6;ITGB1;IFNGR2;H2-AA;HLA-DRA;HLA-DPA1;CYBA;NCF4
ToxoplasmosisPIK3CG;PIK3R5;MAPK12;HLA-DPB1;HSPA6;LAMA4;LAMB2;IFNGR2;NFKBIB
Staphylococcus aureus infectioncgr2b;CFH;CFI;FCGR3;FCGR3B;GM5077;ICAM1;Itgam&Itgb2;C3AR1
TuberculosisMAPK9;MAPK11;HLA-DPA1;CAMK2B;TLR1;CALM1;Il23a; Il12b;IL10RB;LAMP2
Influenza AHLA-DQB1;OAS1A;IFNA12;EIF2AK3;ACTG1;NLRP3;NFKBIA;IFNA3;BCL2L2-PABPN1
HTLV-I infectionTRP53INP1;SRF;LTBR;ETS1;IL6;CDC16;MSX1;CRTC1;TP53
Herpes simplex infectionMAPK10;NFKBIB;BF2;TAF3;HCFC2;TBPL2;MHC2DCB;PVRL1;MAPK8
Epstein-Barr virus infectionENTPD1;POLR3G;HLA-DQB1;POLR2K;POLR2A;STAT3;POLR1D;PLCG2;YWHAG
AsthmaHLA-DRB3;CD40;HLA-DRB5;HLA-DOA;IL9;IL4;EPX;CD40LG;IL13
AutoiFAS;HLA-DMA;HLA-C;HLA-DRB1;TG;HLA-DRA;IFNA21;PRF1;HLA-B
ne thyroid diseaseIFNA6;Ifna15;HLA-F;TPO;HLA-DOA;Fasl;HLA-DRB5;TSHB;Il2
Inflammatory bowel disease (IBD)HLA-DMA;IL22;MAF;IL13;IL1B;IL12A;STAT4;Il23a;Il23a; Il12b
Systemic lupus erythematosusIFNG;HIST1H3H;HIST2H2BB;HLA-DRB3;GM14477;C2;H2-AA;C7;HIST3H2A
Rheumatoid arthritisMMP1;IL1B;HLA-DOA;HLA-DQA2;CXCL1;HLA-DPA1;HLA-DRB5;IFNG;CTLA4
Allograft rejectionHLA-DRB3;HLA-DPA1;FAS;TNF;HLA-DOB;GZMB;HLA-DMB;HLA-C;HLA-DRB5
Graft-versus-host diseaseHLA-DQA1;HLA-F;GZMB;Fasl;KIR2DL3;KIR2DL1;H2-AB1;H2-AA;HLA-DPB1
Viral myocarditisBID;HLA-E;SGCB;ABL1;ABL2;LAMA2;CCND1;ITGB2;HLA-DOA

HLA-DRA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein complex bindingHLA-DOB;ANXA11;HLA-DOA;HLA-DRB1;CD74;ATP1B1;HLA-DMA;HLA-DRA;YWHAE
MHC class II receptor activityHLA-DQB1;KRT17;HLA-DPA1;HLA-DQA1;HLA-DRA;HLA-DOA;HLA-DQB2;HLA-DRB3;HLA-DOB
peptide antigen bindingMHC1UFA;HLA-DQA1;MHC1UEA;MHC1ZKA;H2-AB1;MHC1UBA;MHC1ZE;HLA-DPA1;HLA-DRB1

HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.

HLA-DRB1; HLA-DRB1; HLA-DMA

Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What role does the HLA-DRA protein play in tumors? 12/19/2019

HLA-DRA protein can present tumor-associated antigen fragments to immune cells during tumor immunity, thereby activating the immune response, which is of great significance for tumor immunotherapy.

How to detect the expression level of HLA-DRA protein? 12/17/2019

Immunohistochemistry, flow cytometry, Western blot and other techniques can be used to detect the expression level of HLA-DRA protein.

What is the role of HLA-DRA protein in the immune system? 09/13/2019

The HLA-DRA protein is mainly involved in the antigen presentation process in the immune system, mediating the antigen fragment to T cells, thereby triggering an immune response against the antigen.

Is there a link between HLA-DRA protein polymorphisms and disease development? 07/22/2019

There is an association between polymorphisms of HLA-DRA proteins and the occurrence of certain diseases, as different HLA-DRA genotypes may affect the effectiveness of immune responses and thus susceptibility to diseases.

Can HLA-DRA protein be used as a target for immunotherapy? 06/17/2019

Yes, due to the important role of HLA-DRA protein in the immune system, it is considered a potential immunotherapy target that can be used to improve therapeutic strategies for immune diseases.

Is HLA-DRA protein associated with infectious diseases? 01/01/2019

Yes, HLA-DRA protein is associated with the occurrence and development of infectious diseases such as viral and bacterial infections because it is involved in regulating the immune response and affecting the outcome of infection.

Customer Reviews (3)

Write a review
Reviews
07/10/2021

    Both purity and biological activity are commendable.

    04/20/2021

      It provides a strong guarantee for the accuracy of the experimental results.

      02/09/2019

        Wide range of applications and provides support for scientific research.

        Ask a Question for All HLA-DRA Products

        Required fields are marked with *

        My Review for All HLA-DRA Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends