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Official Full Name major histocompatibility complex, class II, DR alpha
Background HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Synonyms MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Yeast
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DRA-2300H Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged Yeast His
    Human HLA-DRA-353H Recombinant Human HLA-DRA Protein, His-tagged E.coli His
    Human HLA-DRA-490H Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged E.coli His
    Human HLA-DRA-5501HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome ATP6V0A1A; ITGA5; MHC1UEA; ATP6V1C1B; FCGR2B; C3A.2; ATP6V0A4; STX18; RAB5AB; MHC2A
    Cell adhesion molecules (CAMs) ITGB8; ITGA8; CLDNC; CLDNJ; MHC1UEA; CD276; CLDN5; NLGN2B; CD4; NEO1A
    Antigen processing and presentation KIR2DL1; HSP90AA1; NFYA; HSPA1L; HLA-DRB3; HSP90AB1; TNF; B2M; HLA-DPA1; CD8B
    Hematopoietic cell lineage CD44; Kitl; CD3E; CD3D; CD1D; CD8A; CD1D2; Cd24a; CD7; ITGA5; IL5RA
    Intestinal i CCL25B; MHC2A; CD28; BLB1; CCL25; CD40LG; CD40; CCR9A; Il2; HLA-DRB1
    ne network for IgA production IL4; MHC2DEB; CD28; Icosl; MHC2A; HLA-DQA1; HLA-DOA; HLA-DQB1; HLA-DQA2; ITGB7
    Type I diabetes mellitus TNF; INS1; FAS; HLA-G; HLA-DRA; HLA-DMA; CPE; HLA-DRB3; Fasl; HLA-DRB1
    Toxoplasmosis NFKB1; XIAP; TNFRSF1A; TAB2; PIK3CG; Toxoplasma Gondii Microneme Protein MIC3; NFKBIA; IKBKG; GNAI2; LAMA2
    Staphylococcus aureus infection HLA-DQB1; HLA-DPA1; FCGR2C; DSG1C; C1R; GM5077; HLA-DOB; ITGB2L; FCGR2A; Hc
    Tuberculosis IFNA8; HLA-DOB; Il23a; Il12b; CAMK2B; CALM2; APAF1; RIPK2; HLA-DRB3; IFNA17; MAPK3
    Influenza A MAPK10; NLRX1; MAP2K1; IRF7; ACTB; IFNG; EIF2AK2; HLA-DOB; HLA-DMB; H2-AB1
    Herpes simplex infection EEF1DA; SRSF9; C3; FAS; PTPN11B; NFKBIAA; PPP1CAA; TLR3; TAF6; IFNB1
    Epstein-Barr virus infection YWHAB; NUP214; PLCG2; NFKB1; HLA-C; IRF3; RELB; TNFAIP3; IL10RB; PSMC4
    Autoi HLA-DQA2; TSHB; H2-AA; IFNA4; HLA-G; CD80; IFNA5; HLA-DPB1; IL4; HLA-C
    ne thyroid disease HLA-DMB; TG; TSHB; IL5; IL4; HLA-DOA; IFNA17; Fasl; HLA-G; FAS
    Inflammatory bowel disease (IBD) IL12A; H2-AA; HLA-DMB; GATA3; IL6; HLA-DRB3; IFNGR2; HLA-DOA; RELA; IL5
    Systemic lupus erythematosus HIST2H2BB; HLA-DOB; HIST1H4N; HIST1H2AC; HIST1H2BL; HIST1H2BF; H2AFB2; HIST2H4; HIST1H2BO; TNF
    Rheumatoid arthritis HLA-DQA1; CD86; CXCL1; ATP6V1F; HLA-DOB; ITGAL; HLA-DRB4; TGFB3; ITGB2L; TNF
    Allograft rejection HLA-C; HLA-B; HLA-DQB1; IL10; HLA-DPA1; HLA-DRB4; HLA-G; HLA-DPB1; HLA-F; HLA-A
    Graft-versus-host disease FASLG; CD28; HLA-DRB3; KLRC1; HLA-A; KLRD1; HLA-DPA1; IL1B; H2-AA; HLA-DQA1
    Viral myocarditis H2-AB1; ABL1; Casp3; HLA-DRB5; HLA-E; SGCG; RAC3; HLA-B; H2-AA; ACTB

    HLA-DRA has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding ATP1B1; MS4A1; HLA-DMB; HSP90AA1; HSP90AB1; HLA-DMA; CD81; HLA-DRA; HLA-DOB; CD74
    MHC class II receptor activity HLA-DRB4; HLA-DPA1; HLA-DRB1; HLA-DOB; KRT17; HLA-DRB3; HLA-DQB1; HLA-DRA; HLA-DQA1; HLA-DQB2
    peptide antigen binding MHC1UDA; H2-AA; MHC1ZFA; CD209; HLA-DRA; MHC1ZDA; MHC1UHA; HLA-DPA1; TAPBP; HLA-A

    HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.


    Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
    Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).

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