hla-dra
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  • Official Full Name
  • major histocompatibility complex, class II, DR alpha
  • Background
  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
  • Synonyms
  • MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12
Cat.#:HLA-DRA-353HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-DRA Protein, His-tagged
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Cat.#:HLA-DRA-490HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human major histocompatibility complex, class II, DR alpha, His-tagged
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Cat.#:HLA-DRA-5501HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HLA 293 Cell Lysate
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Involved Pathway

HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
SFTPD; THBS3A; Itgam&Itgb2; TAP1; ATP6V0A1; THBS1; ATP6AP1B; ATPV0E2; STX12; HLA-DRB1
Cell adhesion molecules (CAMs)
CD34; GLYCAM1; SPN; NLGN2B; HLA-DOB; JAM2; CD2; BLB1; HLA-E; ICAM2
Antigen processing and presentation
HLA-DQA1; IFNG; HLA-DOA; NFYC; H2-Q10; HLA-DQB1; CANX; RFXAP; CTSB; KIR3DL2
Hematopoietic cell lineage
MME; HLA-DRA; CSF3R; ITGB3; GYPA; FCGR1A; IL9R; CD8B1; CD3E; CD3D; CD34
Intestinal i
HLA-DOB; IL-15RA; CD80; HLA-DRA; CXCL12B; HLA-DQB1; LTBR; HLA-DOA; CXCL12; HLA-DPA1
ne network for IgA production
CCL25; HLA-DRB1; ITGA4; CXCR4; MAP3K14; HLA-DOB; HLA-DQB1; HLA-DRB5; HLA-DQA2; BLA
Type I diabetes mellitus
FAS; PTPRN2; HLA-DPA1; H2-AB1; CPE; IL12A; GAD1; HLA-DMB; CD80; IL12B
Leishmaniasis
FCGR3; IRAK4; HLA-DRA; MAP3K7; FCGR1; HLA-DOB; NOS2; ITGA4; HLA-DRB1; NFKB1
Toxoplasmosis
PIK3R2; LDLR; TAB2; IRAK1; CD40LG; NFKB1; NFKBIB; HLA-DPB1; TGFB1; NFKBIA
Staphylococcus aureus infection
HLA-DQA1; FCAR; C1QC; FCGR2A; HLA-DQA2; HLA-DRB1; FGG; HLA-DRB4; C3; C1R
Tuberculosis
FCGR1; IL1A; FCGR3B; CALM1; NFYC; RELA; LSP1; IFNA10; HLA-DRB5; Il23a
Influenza A
NXF2; TNFRSF10B; CPSF4; TMPRSS2; HLA-DMB; PIK3CB; FDPS; KPNA2; NFKB1; SLC25A6
HTLV-I infection
IL15; SMAD4; PIK3CA; TNFRSF13C; DVL1; HLA-DQB1; ANAPC2; POLE2; FDPS; MAP3K3
Herpes simplex infection
HLA-F; TAF5; OAS1A; BF2; CASP3B; SRSF7; HLA-DPA1; IFNGR1; IL1B; MHC2A
Epstein-Barr virus infection
XPO1; AKAP8L; GSK3B; HDAC4; PSMD4; RBPJ; HLA-DPA1; SPI1; POLR3G; PSMD13
Asthma
H2-AB1; RNASE3; HLA-DQA1; H2-AA; HLA-DRB1; HLA-DRB5; FCER1G; PRG2; HLA-DQA2; HLA-DMB
Autoi
IFNA1; HLA-DPB1; TPO; TSHR; HLA-DOB; Fasl; TSHB; IFNA12; CD40LG; HLA-E
ne thyroid disease
HLA-DRA; IFNA1; HLA-E; Il2; HLA-DOA; HLA-DQA1; TSHB; HLA-F; IFNA21; HLA-DMB
Inflammatory bowel disease (IBD)
HLA-DRA; H2-AA; GATA3; HLA-DQA1; IL12RB1; HLA-DPB1; IFNGR1; HLA-DRB1; Il23a; Il12b; IL18
Systemic lupus erythematosus
HIST1H2BQ; HIST1H2BM; TNF; HIST1H2AO; HIST3H2BB-PS; HIST1H4H; GM5077; C2; HIST1H2AI; C8B
Rheumatoid arthritis
ITGB2L; HLA-DMA; IL15; FOS; FLT1; MMP3; HLA-DQA2; TGFB1; IL-8; TEK
Allograft rejection
IL12B; H2-AA; HLA-F; HLA-DPB1; FASLG; CD28; HLA-B; Il2; IL10; HLA-G
Graft-versus-host disease
FASLG; HLA-DPA1; HLA-DPB1; HLA-DOA; PRF1; GZMB; H2-AB1; FAS; HLA-F; Il2
Viral myocarditis
HLA-B; HLA-DPB1; HLA-DOA; HLA-DRB5; ABL1; LAMA2; ACTG1; CXADR; CASP9; ITGB2

Protein Function

HLA-DRA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein complex binding
Related Protein MS4A1; CD81; HLA-DOB; PKM2; HLA-DRB1; YWHAE; HLA-DRA; CD74; HLA-DOA; HSP90AB1
Function MHC class II receptor activity
Related Protein HLA-DRB3; HLA-DPA1; HLA-DQA1; HLA-DQA2; HLA-DRA; HLA-DRB4; HLA-DRB1; HLA-DQB2; KRT17; HLA-DOB
Function peptide antigen binding
Related Protein HLA-DRB1; HLA-DRB5; H2-AB1; MHC1UHA; CD209; DHCR24; MR1; HLA-A; H2-Q10; CLEC4M

Interacting Protein

HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.
HLA-DRB1; HLA-DRB1; HLA-DMA

HLA-DRA Related Articles

Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).