HLA-DRA
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Official Full Name
major histocompatibility complex, class II, DR alpha
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Overview
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. -
Synonyms
MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- E. coli
- E.coli
- HEK293
- Yeast
- GST
- His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-DRA-490H | Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged | E.coli | His | ||
Human | HLA-DRA-5501HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | N/A | ||
Human | HLA-DRA-5321H | Recombinant Human HLA-DRA protein, His-tagged | E.coli | His | 28-254aa | |
Human | HLA-DRA-353H | Recombinant Human HLA-DRA Protein, His-tagged | E.coli | His | Lys27~Glu216 | |
Human | HLA-DRA-2300H | Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged | Yeast | His | 26-254 aa | |
Human | HLA-DRA-231H | Recombinant Human HLA-DRA protein, GST-tagged | E. coli | GST | 24-218 aa | |
Human | HLA-DRA-3571H | Recombinant Human HLA-DRA Protein (Lys27-Glu216), His tagged | E.coli | His | Lys27-Glu216 |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-DRA Related Articles
- HLA-DRA Related Research Area
HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | EEA1;NCF1;RAC1;BLA;Cd209g;ATP6V0C;CALR;TAP2;MRC2 |
Cell adhesion molecules (CAMs) | HLA-DOB;CNTN1A;PVRL2;ICOS;BMA2;ITGA6B;ITGA4;CADM3;ITGA6 |
Antigen processing and presentation | NFYB;NFYC;KIR2DL1;KLRC3;HLA-DRB1;LGMN;PSME2;KIR3DL2;HSPA1B |
Hematopoietic cell lineage | TNF;IL11RA2;GYPA;HLA-DRB1;FCGR1A;CR1;EPOR;IL5;CD1D2 |
Intestinal i | BLA;IL4;CCR10;HLA-DMB;HLA-DOB;HLA-DQA1;MHC2A;CD28;CD40LG |
ne network for IgA production | TNFRSF17;CXCR4A;HLA-DPB1;CD86;HLA-DRA;HLA-DQA1;H2-AA;CCR10;CXCL12 |
Type I diabetes mellitus | INS;HLA-DPB1;HLA-DQB1;HLA-B;H2-AA;HLA-DOB;HSPD1;FASLG;HLA-DPA1 |
Leishmaniasis | HLA-DOA;PTPN6;ITGB1;IFNGR2;H2-AA;HLA-DRA;HLA-DPA1;CYBA;NCF4 |
Toxoplasmosis | PIK3CG;PIK3R5;MAPK12;HLA-DPB1;HSPA6;LAMA4;LAMB2;IFNGR2;NFKBIB |
Staphylococcus aureus infection | cgr2b;CFH;CFI;FCGR3;FCGR3B;GM5077;ICAM1;Itgam&Itgb2;C3AR1 |
Tuberculosis | MAPK9;MAPK11;HLA-DPA1;CAMK2B;TLR1;CALM1;Il23a; Il12b;IL10RB;LAMP2 |
Influenza A | HLA-DQB1;OAS1A;IFNA12;EIF2AK3;ACTG1;NLRP3;NFKBIA;IFNA3;BCL2L2-PABPN1 |
HTLV-I infection | TRP53INP1;SRF;LTBR;ETS1;IL6;CDC16;MSX1;CRTC1;TP53 |
Herpes simplex infection | MAPK10;NFKBIB;BF2;TAF3;HCFC2;TBPL2;MHC2DCB;PVRL1;MAPK8 |
Epstein-Barr virus infection | ENTPD1;POLR3G;HLA-DQB1;POLR2K;POLR2A;STAT3;POLR1D;PLCG2;YWHAG |
Asthma | HLA-DRB3;CD40;HLA-DRB5;HLA-DOA;IL9;IL4;EPX;CD40LG;IL13 |
Autoi | FAS;HLA-DMA;HLA-C;HLA-DRB1;TG;HLA-DRA;IFNA21;PRF1;HLA-B |
ne thyroid disease | IFNA6;Ifna15;HLA-F;TPO;HLA-DOA;Fasl;HLA-DRB5;TSHB;Il2 |
Inflammatory bowel disease (IBD) | HLA-DMA;IL22;MAF;IL13;IL1B;IL12A;STAT4;Il23a;Il23a; Il12b |
Systemic lupus erythematosus | IFNG;HIST1H3H;HIST2H2BB;HLA-DRB3;GM14477;C2;H2-AA;C7;HIST3H2A |
Rheumatoid arthritis | MMP1;IL1B;HLA-DOA;HLA-DQA2;CXCL1;HLA-DPA1;HLA-DRB5;IFNG;CTLA4 |
Allograft rejection | HLA-DRB3;HLA-DPA1;FAS;TNF;HLA-DOB;GZMB;HLA-DMB;HLA-C;HLA-DRB5 |
Graft-versus-host disease | HLA-DQA1;HLA-F;GZMB;Fasl;KIR2DL3;KIR2DL1;H2-AB1;H2-AA;HLA-DPB1 |
Viral myocarditis | BID;HLA-E;SGCB;ABL1;ABL2;LAMA2;CCND1;ITGB2;HLA-DOA |
HLA-DRA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class II protein complex binding | HLA-DOB;ANXA11;HLA-DOA;HLA-DRB1;CD74;ATP1B1;HLA-DMA;HLA-DRA;YWHAE |
MHC class II receptor activity | HLA-DQB1;KRT17;HLA-DPA1;HLA-DQA1;HLA-DRA;HLA-DOA;HLA-DQB2;HLA-DRB3;HLA-DOB |
peptide antigen binding | MHC1UFA;HLA-DQA1;MHC1UEA;MHC1ZKA;H2-AB1;MHC1UBA;MHC1ZE;HLA-DPA1;HLA-DRB1 |
HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.
HLA-DRB1; HLA-DRB1; HLA-DMA
- Q&As
- Reviews
Q&As (6)
Ask a questionHLA-DRA protein can present tumor-associated antigen fragments to immune cells during tumor immunity, thereby activating the immune response, which is of great significance for tumor immunotherapy.
Immunohistochemistry, flow cytometry, Western blot and other techniques can be used to detect the expression level of HLA-DRA protein.
The HLA-DRA protein is mainly involved in the antigen presentation process in the immune system, mediating the antigen fragment to T cells, thereby triggering an immune response against the antigen.
There is an association between polymorphisms of HLA-DRA proteins and the occurrence of certain diseases, as different HLA-DRA genotypes may affect the effectiveness of immune responses and thus susceptibility to diseases.
Yes, due to the important role of HLA-DRA protein in the immune system, it is considered a potential immunotherapy target that can be used to improve therapeutic strategies for immune diseases.
Yes, HLA-DRA protein is associated with the occurrence and development of infectious diseases such as viral and bacterial infections because it is involved in regulating the immune response and affecting the outcome of infection.
Customer Reviews (3)
Write a reviewBoth purity and biological activity are commendable.
It provides a strong guarantee for the accuracy of the experimental results.
Wide range of applications and provides support for scientific research.
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