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HLA-DRB4

  • Official Full Name

    major histocompatibility complex, class II, DR beta 4

  • Overview

    HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
  • Synonyms

    HLA-DRB4; major histocompatibility complex, class II, DR beta 4; HLA DR4B; DR4; DR-4; leukocyte antigen; MHC class2 antigen; MHC HLA DR-beta chain; MHC class II antigen DRB4; DRB1 transplantation antigen; human leucocyte antigen DRB4; MHC class II antigen;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DRB4-1209H Recombinant Human HLA-DRB4, GST-tagged Wheat Germ GST
Human HLA-DRB4-5492HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DRB4-3738H Recombinant Human HLA-DRB4 protein, GST-tagged E.coli GST 1-266 aa
Human HLA-DRB4-235HF Recombinant Full Length Human HLA-DRB4 Protein, GST-tagged In Vitro Cell Free System GST 30 a.a. - 266 a.a.
Human HLA-DRB4-2263H Recombinant Human HLA-DRB4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DRB4 Related Articles

HLA-DRB4 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB4 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeHLA-DMA;ACTB;TUBA2;THBS1;Cd209g;ATP6V1A;VAMP3;MRC1;TLR2
Cell adhesion molecules (CAMs)CLDN10A;OCLN;NLGN3;CLDN10;CLDN17;PVRL3;NLGN4X;Icosl;CLDN23
Antigen processing and presentationHLA-F;KLRD1;TAP2;H2-AA;HSPA1A;KIR2DS5;PSME2;NFYC;CTSB
Hematopoietic cell lineageGP5;HLA-DRB5;FCER2;HLA-DRB4;CD9;FLT3LG;CSF3R;GP1BA;CD3E; CD3D
Intestinal iCD80;CXCR4;HLA-DQB1;PIGR;HLA-DRB1;HLA-DOA;TGFB1;MHC2DCB;HLA-DPB1
ne network for IgA productionIl2;HLA-DMA;CD28;IL6;HLA-DRB4;ICOSLG;MHC2DAB;IL4;H2-AA
Type I diabetes mellitusHLA-G;CD86;CPE;HLA-DRB5;HLA-F;GAD1;HLA-DOA;H2-Q10;ICA1
LeishmaniasisMYD88;NCF4;HLA-DQB1;MAPK11;PTPN6;FCGR1;FCGR3;HLA-DOA;TLR2
ToxoplasmosisTAB2;IRAK4;BCL2L1;TRAF6;MAPK9;IRGM1;HLA-DPB1;HLA-DMA;MAPK10
Staphylococcus aureus infectionITGAL;FCGR2C;HLA-DQB1;DSG1C;FGG;HLA-DMB;HLA-DPB1;C1RA;ICAM1
TuberculosisRAB7A;Ifna15;IL10RA;HLA-DRB5;RHOA;CAMK2D;CAP18;IL18;cgr2b
Influenza AEP300;IFNA6;HLA-DMA;DNAJB1;PIK3R1;IFNAR1;HLA-DRB4;PABPN1L;PIK3R2
HTLV-I infectionTBPL1;NFKBIA;FZD5;AKT2;H2-AB1;TSPO;IL15;PDGFRB;TGFBR2
Herpes simplex infectionBF1;SRPK1;CDC34;MAPK10;MHC1UXA2;IRF9;STAT1B;CCL5;IFIH1
Epstein-Barr virus infectionPOLR3D;CR2;EIF2AK1;CSNK2A2;POLR2B;SPI1;PSMD12;XPO1;HDAC2
AsthmaHLA-DOA;HLA-DRB1;HLA-DMA;IL13;HLA-DQA1;EPX;TNF;HLA-DPA1;MS4A2
AutoiHLA-DOA;CD80;Fasl;H2-Q10;GZMB;HLA-G;IFNA1;HLA-DRA;IFNA17
ne thyroid diseaseTG;GZMB;IFNA12;CD28;IL5;IFNA2;TSHB;IFNA7;HLA-F
Inflammatory bowel disease (IBD)IFNGR2;H2-AA;IL21;IL17F;TGFB3;IL4;Il23a; Il12b;TGFB1;IL17A
Systemic lupus erythematosusCD80;HLA-DRB3;HIST1H2BN;HIST1H3E;HIST1H2BM;H2AFB2;HLA-DOB;FCGR1;HIST1H3D
Rheumatoid arthritisH2-AA;HLA-DQA1;TLR2;ATP6V0C;HLA-DRB4;ATP6V1E1;TLR4;CD28;CCL3
Allograft rejectionIFNG;CD86;HLA-DMA;HLA-A;HLA-DRB3;IL12B;Il2;HLA-DRB1;GZMB
Graft-versus-host diseaseKIR2DL3;GZMB;HLA-C;HLA-DRB3;HLA-DPB1;H2-AA;HLA-DOB;H2-Q10;IFNG
Viral myocarditisHLA-DQA2;EIF4G2;HLA-A;HLA-DQA1;CCND1;SGCA;SGCB;HLA-G;HLA-DQB1

HLA-DRB4 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB4 itself. We selected most functions HLA-DRB4 had, and list some proteins which have the same functions with HLA-DRB4. You can find most of the proteins on our site.

Function Related Protein
MHC class II receptor activityHLA-DQA2;HLA-DRB1;HLA-DQB1;HLA-DRA;HLA-DRB4;KRT17;HLA-DOB;HLA-DQA1;HLA-DOA
peptide antigen bindingMHC1ZDA;TAP1;HLA-DPA1;MHC1ZE;HLA-DRA;HLA-B;HLA-C;MHC1UBA;MHC1UIA
protein bindingADCYAP1R1;SUPT4H1;CALCOCO1;HIST1H1E;SEMA7A;SNAI2;PCMT1;CHMP4B;GPM6A

HLA-DRB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB4.

ASMTL

Rasmussen, S; Donskov, F; et al. Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:487-496(2013).
Resse, M; Paolillo, R; et al. Anti-HLA-A, -B, -DR,-DQB1 and-DQA1 antibodies reactive epitope determination with HLAMatchmaker in multipare awaiting list for heart transplant. HUMAN IMMUNOLOGY 74:937-941(2013).
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