hnf1b
Share
  • Official Full Name
  • HNF1 homeobox B
  • Background
  • This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HNF1B; HNF1 homeobox B; TCF2, transcription factor 2, hepatic; LF B3; variant hepatic nuclear factor; hepatocyte nuclear factor 1-beta; HNF1beta; LFB3; MODY5; VHNF1; TCF-2; HNF-1B; HNF-1-beta; HNF1 beta A; homeoprotein LFB3; transcription factor 2, hepat
Cat.#:HNF1B-4892HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HNF1B Protein, GST-tagged
+Inquiry
Cat.#:HNF1B-564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HNF1B Protein, His-tagged
+Inquiry
Cat.#:HNF1B-13862HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HNF1B, GST-tagged
+Inquiry
Cat.#:HNF1B-29461THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HNF1B
+Inquiry
Cat.#:HNF1B-7751MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HNF1B Protein
+Inquiry
Cat.#:HNF1B-2877RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HNF1B Protein
+Inquiry
Cat.#:HNF1B-2115RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HNF1B Protein, His-tagged
+Inquiry
Cat.#:HNF1B-5460HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNF1B 293 Cell Lysate
+Inquiry

Involved Pathway

HNF1B involved in several pathways and played different roles in them. We selected most pathways HNF1B participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Maturity onset diabetes of the young
INS2; FOXA3; INS1; PAX6; PKLR; NKX6-1; HHEX; PAX4; INS; FOXA2

Protein Function

HNF1B has several biochemical functions, for example, DNA binding, core promoter proximal region DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1B itself. We selected most functions HNF1B had, and list some proteins which have the same functions with HNF1B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DNAJB6; KIF4A; HER7; PREB; PCXB; ZNF76; NR1D2A; RFX8; DEDD; ZNF446
Function core promoter proximal region DNA binding
Related Protein HNF1B
Function protein binding
Related Protein GLRA1; CDX1; ATXN1L; KIF3B; AHI1; SPINLW1; EGR1; COBRA1; SIN3A; MSLN
Function protein complex binding
Related Protein HCLS1; RPTOR; TELO2; CFLAR; EP300; RIPK1; RXRA; HSPD1; CDK2; PDCL
Function protein heterodimerization activity
Related Protein KCNK9; CHRNA3; ADRB1; ABTB2; CD3G; RALGAPA2; MAPK6; TAF9B; KCNN1; MYF6
Function protein homodimerization activity
Related Protein ID1; GPD1A; UGT1A7; DMRTC2; SLC9A7; TCF3A; TERF2; CADM1B; IRAK3; DRD2
Function sequence-specific DNA binding
Related Protein HOXD12; ZNF148; TBX1; LHX3; NKX3; FOXD1; SIX9; ZNF323; NR3C2; IRX1A
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein AHR; IRF8; CEBPA; FOXF1; MYOG; NFATC1; FOXC1; POU3F1; PURA; JUN
Function transcription factor activity, sequence-specific DNA binding
Related Protein TBX4; NKX6-1; RXRBA; DMRTC1B; FOXJ1; ZSCAN4; SOX5; ZFP354C; HMGA1B; TRPS1

Interacting Protein

HNF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1B.
ribF