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HNF1B

  • Official Full Name

    HNF1 homeobox B

  • Overview

    This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HNF1B; HNF1 homeobox B; TCF2, transcription factor 2, hepatic; LF B3; variant hepatic nuclear factor; hepatocyte nuclear factor 1-beta; HNF1beta; LFB3; MODY5; VHNF1; TCF-2; HNF-1B; HNF-1-beta; HNF1 beta A; homeoprotein LFB3; transcription factor 2, hepat;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNF1B-13862H Recombinant Human HNF1B, GST-tagged E.coli GST N-term-310a.a.
Human HNF1B-29461TH Recombinant Human HNF1B Wheat Germ N/A 105 amino acids
Human HNF1B-4892H Recombinant Human HNF1B Protein, GST-tagged Wheat Germ GST
Human HNF1B-5460HCL Recombinant Human HNF1B 293 Cell Lysate HEK293 N/A
Human HNF1B-3672HF Recombinant Full Length Human HNF1B Protein, GST-tagged In Vitro Cell Free System GST 557 amino acids
Human HNF1B-564H Recombinant Human HNF1B Protein, His-tagged E.coli His Pro159~Phe300
Mouse HNF1B-7751M Recombinant Mouse HNF1B Protein Mammalian Cell His
Mouse Hnf1b-6335M Recombinant Mouse Hnf1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HNF1B-4254M Recombinant Mouse HNF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HNF1B-4254M-B Recombinant Mouse HNF1B Protein Pre-coupled Magnetic Beads HEK293
Rat HNF1B-2877R Recombinant Rat HNF1B Protein Mammalian Cell His
Rat HNF1B-2532R Recombinant Rat HNF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HNF1B-2532R-B Recombinant Rat HNF1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HNF1B-2115R Recombinant Rhesus monkey HNF1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque HNF1B-1936R Recombinant Rhesus Macaque HNF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HNF1B-1936R-B Recombinant Rhesus Macaque HNF1B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HNF1B Related Research Area

HNF1B involved in several pathways and played different roles in them. We selected most pathways HNF1B participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Maturity onset diabetes of the youngSLC2A2;BHLHA15;HNF1B;HES1;HNF4G;HNF1A;FOXA2;ONECUT1;INS

HNF1B has several biochemical functions, for example, DNA binding, core promoter proximal region DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1B itself. We selected most functions HNF1B had, and list some proteins which have the same functions with HNF1B. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNFE2L2B;TCF4;ZNF621;ZBTB37;ZNF511;MXI1;TLR8;CERS4;HOXB5B
core promoter proximal region DNA binding
protein bindingPPARGC1A;GRHL3;DOCK4;INHBA;ZFYVE9;CEACAM6;NLRC4;CLK4;ARID1A
protein complex bindingPTK2B;GNB1;RRAS;IGBP1;BAG3;RPH3A;MTHFR;AP2A1;ATP6V1B1
protein heterodimerization activityHIST1H2B7;TLX1;ADIPOR1;INHA;ARNT;UGT1A1;TXLNG;MYOG;HIST1H2BL
protein homodimerization activityS100A6;CHEK2;JUP;CRYAB;SERPINF2;TERF1;CEACAM5;BCL11A;NKX2
sequence-specific DNA bindingZKSCAN1;ZFP42;BCL2;HOXC12B;PHOX2BA;CREB3L3L;FOXA;POU3F2B;HOXC5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingMYF6;SOX9;GATA4;THRA;TLE4;RFX1;HIF1A;MYF5;CEBPB
transcription factor activity, sequence-specific DNA bindingZNF12;SOX32;FOXD2;MYF6;KLF7;HSF5;SIX1A;NFE2L1B;NEUROD2

HNF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1B.

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