Recombinant Full Length Human HNF1B Protein, GST-tagged

• Cat.No.: HNF1B-3672HF
• Product Overview: Human HNF1B full-length ORF ( NP_000449.1, 1 a.a. - 557 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 87.7 kDa
• Protein Length: 557 amino acids
• AA Sequence: MVSKLTSLQQELLSALLSSGVTKEV LVQALEELLPSPNFGVKLETLPLSP GSGAEPDTKPVFHTLTNGHAKGRLS GDEGSEDGDDYDTPPILKELQALNT EEAAEQRAEVDRMLSEDPWRAAKMI KGYMQQHNIPQREVVDVTGLNQSHL SQHLNKGTPMKTQKRAALYTWYVRK QREILRQFNQTVQSSGNMTDKSSQD QLLFLFPEFSQQSHGPGQSDDACSE PTNKKMRRNRFKWGPASQQILYQAY DRQKNPSKEEREALVEECNRAECLQ RGVSPSKAHGLGSNLVTEVRVYNWF ANRRKEEAFRQKLAMDAYSSNQTHS LNPLLSHGSPHHQPSSSPPNKLSGV RYSQQGNNEITSSSTISHHGNSAMV TSQSVLQQVSPASLDPGHNLLSPDG KMISVSGGGLPPVSTLTNIHSLSHH NPQQSQNLIMTPLSGVMAIAQSLNT SQAQSVPVINSVAGSLAALQPVQFS QQLHSPHQQPLMQQSPGSHMAQQPF MAAVTQLQNSHMYAHKQEPPQYSHT SRFPSAMVVTDTSSISTLTNMSSSK QCPLQAW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HNF1B HNF1 homeobox B [ Homo sapiens ]
• Official Symbol: HNF1B
• Synonyms: HNF1B; HNF1 homeobox B; TCF2, transcription factor 2, hepatic; LF B3; variant hepatic nuclear factor; hepatocyte nuclear factor 1-beta; HNF1beta; LFB3; MODY5; VHNF1; TCF-2; HNF-1B; HNF-1-beta; HNF1 beta A; homeoprotein LFB3; transcription factor 2, hepatic; FJHN; HNF2; TCF2; HPC11; LF-B3
• Gene ID: 6928
• mRNA Refseq: NM_000458
• Protein Refseq: NP_000449
• MIM: 189907
• UniProt ID: P35680