hnrnpd
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  • Official Full Name
  • heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
  • Background
  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
  • Synonyms
  • HNRNPD; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); AUF1, heterogeneous nuclear ribonucleoprotein D (AU rich element RNA binding protein 1, 37kD) , HNRPD; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0
Cat.#:HNRNPD-4914HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HNRNPD Protein, GST-tagged
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Cat.#:HNRNPD-13869HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HNRNPD, GST-tagged
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Cat.#:HNRNPD-713HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HNRNPD Protein, His-tagged
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Cat.#:HNRNPD-7761MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HNRNPD Protein
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Cat.#:HNRNPD-2122RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HNRNPD Protein, His-tagged
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Cat.#:HNRNPD-2815CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HNRNPD
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Cat.#:HNRNPD-6181ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HNRNPD
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Cat.#:HNRNPD-5448HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNRNPD 293 Cell Lysate
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Involved Pathway

HNRNPD involved in several pathways and played different roles in them. We selected most pathways HNRNPD participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AUF1 (hnRNP D0) binds and destabilizes mRNA
HNRNPD; PSME3; PSMD9; PSMD5; PSMD14; PSMD10; EIF4G1; PSMA8
Gene Expression
POU2F1B; ADAR; ZNF697; ZNF658; ZNF484; ZNF227; SNAPC1; POLR3G; ZNF225; ZNF688
Processing of Capped Intron-Containing Pre-mRNA
SF3A3; ZMAT5; CSTF1; SNRNP25; THOC4; HNRNPL; PTBP1A; PAPOLA; SF3B2; ZCRB1
Regulation of mRNA stability by proteins that bind AU-rich elements
HUG; ZFP36L1B; HNRNPD; TNPO1; SETB; SETA; ELAVL1; ZFP36L1; KHSRP; SET
mRNA Splicing
SUGP1; HNRNPH1L; HNRNPL; SF3B2; HNRNPL2; HNRNPA0A; HNRNPA0; HNRNPA0L; ZMAT5; PRPF8
mRNA Splicing - Major Pathway
CCAR1; HNRNPUL1; HNRNPA0; HNRNPA0L; SFRS3A; HNRNPH1L; YBX1; HNRNPA2B1; HNRNPH2; HNRNPA0B
mRNA processing
CELF4; PSKH1; WBP4; METTL3; VPRBP; DDX20; RBM12B2; QK; RBM12B1; DDX39

Protein Function

HNRNPD has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPD itself. We selected most functions HNRNPD had, and list some proteins which have the same functions with HNRNPD. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein HNRNPAB; PRPF40B; SMARCE1; HNRPK; SPI1; SAMD4; TRIM21; THOC1; KHDC1A; DAZL
Function nucleotide binding
Related Protein MYO5A; RAB25A; HNRNPL; ATP1A1A.1; RIPK4; RAB12; GRK7B; PRKCHB; CKMT1; MYH8
Function poly(A) RNA binding
Related Protein PNN; PABPC4; TRIP6; UBAP2L; EIF3H; SARS2; LLPH; NQO1; TCOF1; RPL35
Function protein binding
Related Protein MZB1; CHEK2; MEAF6; C9orf16; CHEK1; CBL; TIRAP; PPP2CA; CD74; GTF2B
Function telomeric DNA binding
Related Protein HNRNPD; TINF2; POT1A; TERF1; TP53BP1; CDAN1; TEN1; CTC1; PIF1; TERFA

Interacting Protein

HNRNPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPD.
ING4; HNRNPU; LDHAL6B; Cep152; Kif1c; Shoc2; ACTB; EXOSC2; HNRNPC; SNRPC

HNRNPD Related Articles

Komlosi, K; Duga, B; et al. Phenotypic variability in a Hungarian patient with the 4q21 microdeletion syndrome. MOLECULAR CYTOGENETICS 8:-(2015).
Ishii, T; Hayakawa, H; et al. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells. FREE RADICAL BIOLOGY AND MEDICINE 79:109-116(2015).