HNRNPD

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HNRNPD

Official Full Name heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Background This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
Synonyms HNRNPD; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); AUF1, heterogeneous nuclear ribonucleoprotein D (AU rich element RNA binding protein 1, 37kD) , HNRPD; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HNRNPD-001H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HNRNPD-002H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HNRNPD-003H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HNRNPD-004H Recombinant Human HNRNPD Protein, His-tagged E. coli His
    Human HNRNPD-220H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HNRNPD-2638H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HNRNPD-373H Recombinant Human HNRNPD Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HNRNPD-5765H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Hnrnpd-681M Recombinant Mouse Hnrnpd Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HNRNPD-799H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HNRNPD-13869H Recombinant Human HNRNPD, GST-tagged E.coli GST
    Human HNRNPD-4914H Recombinant Human HNRNPD Protein, GST-tagged Wheat Germ GST
    Human HNRNPD-5448HCL Recombinant Human HNRNPD 293 Cell Lysate HEK293 N/A
    Human HNRNPD-713H Recombinant Human HNRNPD Protein, His-tagged E.coli His
    Mouse HNRNPD-7761M Recombinant Mouse HNRNPD Protein Mammalian Cell His
    Rhesus Macaque HNRNPD-2122R Recombinant Rhesus monkey HNRNPD Protein, His-tagged Mammalian Cell His
    Chicken HNRNPD-2815C Recombinant Chicken HNRNPD Mammalian Cell His
    Zebrafish HNRNPD-6181Z Recombinant Zebrafish HNRNPD Mammalian Cell His

    HNRNPD involved in several pathways and played different roles in them. We selected most pathways HNRNPD participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD10; PSMD14; PSMD9; PSME3; HNRNPD; PSMD5; EIF4G1; PSMA8
    Gene Expression ZFP36L1; ZFP1; GM3258; IPO8; GATAD2A; SAP130; DNMT3L; CSTF3; MED10; CLNS1A
    Processing of Capped Intron-Containing Pre-mRNA HNRNPL2; HNRNPH1; PDCD7; SF3A1; PTBP1B; ZMAT5; U2AF2; HNRNPF; ZCRB1; NXF1
    Regulation of mRNA stability by proteins that bind AU-rich elements KHSRP; ZFP36L1B; ZFP36L1; HNRNPD; SETB; TNPO1; ELAVL1; ANP32A; ZFP36L1A; SETA
    mRNA Splicing BCAS2; RBM5; HNRNPH1L; ZMAT5; HNRNPD; HNRNPH2; HNRNPF; SF3A3; HNRNPA2B1; PTBP1A
    mRNA Splicing - Major Pathway PRPF8; HNRNPA0L; HNRNPR; SF3B4; PCBP2; DNAJC8; RBM5; HNRNPA0B; HNRNPUL1; CCAR1
    mRNA processing NONO; BICC1; ZFP346; ZFP740; DHX15; HNRPL; HNRNPL; RPL36A-HNRNPH2; EIF4E3; SFPQ

    HNRNPD has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPD itself. We selected most functions HNRNPD had, and list some proteins which have the same functions with HNRNPD. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding DIS3L; UPF1; DDX11; EIF4E3; JAKMIP1; CELF2; FBL; HNRNPD; RPP14; RBMX
    nucleotide binding CHD6; RBM39A; GNAO1B; DIRAS1B; RBM4B; CNOT4B; STK26; RAC1A; DAZL; ATP2B2
    poly(A) RNA binding DUSP14; SAMD4A; SUPT5H; DDX24; MAGOH2; MYBBP1A; RBM6; SURF6; RPS10; PTCD3
    protein binding SPTSSA; HSP90AA1.2; SPAG9; RPL27A; SND1; KIAA0649; RNF182; GTF3C4; FAAH; RBM4
    telomeric DNA binding TP53BP1; OBFC1; TERF1; PIF1; CTC1; SMG6; NCL; TERF2; POT1A; TEN1

    HNRNPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPD.

    ING4; HNRNPU; LDHAL6B; Cep152; Kif1c; Shoc2; ACTB; EXOSC2; HNRNPC; SNRPC

    Komlosi, K; Duga, B; et al. Phenotypic variability in a Hungarian patient with the 4q21 microdeletion syndrome. MOLECULAR CYTOGENETICS 8:-(2015).
    Ishii, T; Hayakawa, H; et al. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells. FREE RADICAL BIOLOGY AND MEDICINE 79:109-116(2015).

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