Recombinant Full Length Human HNRNPD Protein, C-Flag-tagged

• Cat.No.: HNRNPD-2053HFL
• Product Overview: Recombinant Full Length Human HNRNPD Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 38.3 kDa
• AA Sequence: MSEEQFGGDGAAAAATAAVGGSAGE QEGAMVAATQGAAAAAGSGAGTGGG TASGGTEGGSAESEGAKIDA SKNEEDEGHSNSSPRHSEAATAQRE EWKMFIGGLSWDTTKKDLKDYFSKF GEVVDCTLKLDPITGRSRGF GFVLFKESESVDKVMDQKEHKLNGK VIDPKRAKAMKTKEPVKKIFVGGLS PDTPEEKIREYFGGFGEVES IELPMDNKTNKRRGFCFITFKEEEP VKKIMEKKYHNVGLSKCEIKVAMSK EQYQQQQQWGSRGGFAGRAR GRGGGPSQNWNQGYSNYWNQGYGNY GYNSQGYGGYGGYDYTGYNNYYGYG DYSNQQSGYGKVSRRGGHQN SYKPY TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: HNRNPD heterogeneous nuclear ribonucleoprotein D [ Homo sapiens (human) ]
• Official Symbol: HNRNPD
• Synonyms: P37; AUF1; AUF1A; HNRPD; hnRNPD0
• Gene ID: 3184
• mRNA Refseq: NM_031370.3
• Protein Refseq: NP_112738.1
• MIM: 601324
• UniProt ID: Q14103