• Official Full Name
  • homeobox D8
  • Background
  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • HOXD8; homeobox D8; homeo box D8 , HOX4, HOX4E; homeobox protein Hox-D8; Homeobox protein Hox-4E; Homeobox protein Hox-5.4; Hox-4.5; Hox-4E; Hox-5.4; HOX4; HXD8_HUMAN; homeo box 4E; homeo box D8; OTTHUMP00000163337; OTTHUMP00000205236; OTTHUMP00000205237; homeobox protein 5.4; HOX4E; HOX5.4
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HOXD8 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HOXD8, His-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HOXD8
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HOXD8 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HOXD8
Source (Host):Species:Human
Product nameRecombinant Human HOXD8 293 Cell Lysate

Protein Function

HOXD8 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD8 itself. We selected most functions HOXD8 had, and list some proteins which have the same functions with HOXD8. You can find most of the proteins on our site.
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZSCAN2; NR1I2; ETV6; GATA4; NHLH2; PRDM15; ZNF549; ZBTB11; RFX6; BCL6AB
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MAFB; GATA2A; HSF2; SRF; STAT3; MYOG; GATA4; NR1I3; DLX2; GATA6

Interacting Protein

HOXD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD8.
PFDN1; RCC1; ANXA7; CDKN1A; q9wmx2-pro_0000037541; q9wmx2-pro_0000037545; q9wmx2-pro_0000037547; q9wmx2-pro_0000037549; q9wmx2-pro_0000037552