hs3st4
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  • Official Full Name
  • heparan sulfate (glucosamine) 3-O-sulfotransferase 4
  • Background
  • This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated;glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus;type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.
  • Synonyms
  • HS3ST4; heparan sulfate (glucosamine) 3-O-sulfotransferase 4; heparan sulfate glucosamine 3-O-sulfotransferase 4; 3OST4; heparan sulfate 3-O-sulfotransferase 4; heparan sulfate 3-O-sulfotransferase-4; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4; 30ST4; 3-OST-4; h3-OST-4;
Cat.#:HS3ST4-5054HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HS3ST4 Protein
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Cat.#:HS3ST4-5055HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HS3ST4 Protein, GST-tagged
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Cat.#:HS3ST4-1971HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Heparan Sulfate (glucosamine) 3-O-Sulfotransferase 4, His-tagged
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Cat.#:HS3ST4-564HTag:His
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human HS3ST4 Protein, His-tagged
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Cat.#:HS3ST4-5085ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HS3ST4
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Involved Pathway

HS3ST4 involved in several pathways and played different roles in them. We selected most pathways HS3ST4 participated on our site, such as Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS3ST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan metabolism
GPC1B; DSEL; SLC26A2; BGNA; BGNB; PRELP; KERA; CHP; LYVE1; OGN
HS-GAG biosynthesis
Gpc2; GPC1B; MAPK1IP1L; GPC1A; HS3ST6; SLC35D2; GPC5A; HS3ST4
Heparan sulfate/heparin (HS-GAG) metabolism
HPSE; GPC1B; GLB1L; HS3ST4; HS3ST6; MAPK1IP1L; GPC1A; CSPG5B; B3GAT2; B4GALT7
Metabolism
CYP4B1; GYG1B; SULT1C4; DCT; SLC25A16; ARV1; ARL2; GLYATL2; SULT2ST2; CSPG5B
Metabolism of carbohydrates
GCKR; HS3ST6; EPM2A; MAPK1IP1L; LYVE1; SLC5A9; SLC35D2; PFKLB; SLC35B3; SLC26A1
heparan sulfate biosynthesis
A4GNT; HS3ST4; MAPK1IP1L
heparan sulfate biosynthesis (late stages)
HS3ST4; A4GNT
metapathway biotransformation
HS3ST6; NAT9; NAA50; CEACAM21; SULT1C2; SULT6B1; KCNAB1; NAT8; NAT14; SULT4A1

Protein Function

HS3ST4 has several biochemical functions, for example, [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS3ST4 itself. We selected most functions HS3ST4 had, and list some proteins which have the same functions with HS3ST4. You can find most of the proteins on our site.
Function
Related Protein
Function [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
Related Protein HS3ST6; HS3ST5; HS3ST1; HS3ST3B1; HS3ST4

HS3ST4 Related Articles

Brusilovsky, M; Cordoba, M; et al. Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses. JOURNAL OF IMMUNOLOGY 191:5256-5267(2013).
Pempe, EH; Burch, TC; et al. Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate. GLYCOBIOLOGY 22:1353-1362(2012).