HSD3B7 Protein, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

HSD3B7

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HSD3B7

Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Background This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms HSD3B7; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; 3 beta-hydroxysteroid dehydrogenase type 7; C(27) 3BETA HSD; SDR11E3; short chain dehydrogenase/reductase family 11E; member 3; BB098564; OTTMUSP00000018895; OTTMUSP00000018897; 3 beta HSD VII; 3 beta hydroxy Delta(5) C27 steroid oxidoreductase; 3 beta hydroxysteroid dehydrogenase type 7; 3 beta hydroxysteroid dehydrogenase type VII; AI195443; C(27) 3 beta HSD; Cca2; Cholest 5 ene 3 beta,7 alpha diol 3 beta dehydrogenase; Confluent 3Y1 cell associated 2; Hydroxy delta 5 steroid dehydrogenase, 3 betaand steroid delta isomerase 7; OTTMUSP00000018894; PFIC4; 3-beta-HSD VII; C(27)-3BETA-HSD; c(27) 3-beta-HSD; OTTHUMP00000163254; 3 beta-hydroxysteroid dehydrogenase type VII; 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; short chain dehydrogenase/reductase family 11E, member 3
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD3B7-13966H Recombinant Human HSD3B7, GST-tagged E.coli GST
    Human HSD3B7-5081H Recombinant Human HSD3B7 Protein, GST-tagged Wheat Germ GST
    Human HSD3B7-5368HCL Recombinant Human HSD3B7 293 Cell Lysate HEK293 N/A
    Rat HSD3B7-2936R Recombinant Rat HSD3B7 Protein Mammalian Cell His
    Zebrafish HSD3B7-10193Z Recombinant Zebrafish HSD3B7 Mammalian Cell His

    HSD3B7 involved in several pathways and played different roles in them. We selected most pathways HSD3B7 participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD3B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary bile acid biosynthesis CYP39A1; CYP46A1.3; CYP7A1A; AKR1C4; CYP46A1; CYP8B1; AMACR; AKR1D1; CYP46A1.2; BAAT
    Metabolic pathways UXS1; ACADL; CHIA.4; HSD3B4; PAFAH2; ASAH1A; CSGALNACT1; POLD1; PAFAH1B2; BCAT2

    HSD3B7 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD3B7 itself. We selected most functions HSD3B7 had, and list some proteins which have the same functions with HSD3B7. You can find most of the proteins on our site.

    Function Related Protein
    3-beta-hydroxy-delta5-steroid dehydrogenase activity HSD3B6; HSD3B2; HSD3B5; HSD3B4; HSD3B7; HSD3B1; SDR42E1; NSDHL
    cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity HSD3B7
    protein binding BLK; RFWD3; ZBTB49; NUBP2; XIRP2; GNB2L1; RPS6KA5; SPRY2; FGFR1OP; PTH2R

    HSD3B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD3B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD3B7.

    SPRY2; KRTAP10-7; KRTAP10-8; KRTAP10-9; NOTCH2NL

    Harini, C; Sainath, SB; et al. Recovery of suppressed male reproduction in mice exposed to progesterone during embryonic development by testosterone. REPRODUCTION 137:439-448(2009).
    THOMAS, JL; FRIEDEN, C; et al. AN NADH-INDUCED CONFORMATIONAL CHANGE THAT MEDIATES THE SEQUENTIAL 3-BETA-HYDROXYSTEROID DEHYDROGENASE/ISOMERASE ACTIVITIES IS SUPPORTED BY AFFINITY LABELING AND THE TIME-DEPENDENT ACTIVATION OF ISOMERASE. JOURNAL OF BIOLOGICAL CHEMISTRY 270:21003-21008(1995).

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