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HSF1

  • Official Full Name

    heat shock transcription factor 1

  • Overview

    The product of this gene is a heat-shock?transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress.?Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
  • Synonyms

    HSF1; heat shock transcription factor 1; heat shock factor protein 1; HSTF1; Heat shock factor 1; Heat shock factor protein 1; Heat shock transcription factor 1; HSF 1; hsf1; HSF1_HUMAN; HSTF 1; HSTF1; HSF 1; HSTF 1; OTTHUMP00000228553; OTTHUMP00000228555;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Arg
  • GST
  • His
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSF1-7050H Recombinant Human HSF1, GST-tagged E.coli GST Full length
Human HSF1-29387TH Recombinant Human HSF1, His-tagged E.coli His 529 amino acids
Human HSF1-327H Recombinant Human Heat Shock Transcription Factor 1, His-tagged E.coli His
Human HSF1-4849H Recombinant Human Heat Shock Transcription Factor 1, GST-tagged E.coli GST
Human HSF1-658H Recombinant Human HSF1 Protein, His-tagged E.coli His Val15~Pro288
Human HSF1-13969H Recombinant Human HSF1, GST-tagged E.coli GST 184-529a.a.
Human HSF1-3963H Recombinant Human HSF1 protein, His-tagged E.coli His Asp2-Ser529
Human HSF1-26697TH Recombinant Human HSF1, His-tagged E.coli His 529 amino acids
Human HSF1-205H Recombinant Human HSF1 protein, Arginine-tagged E.coli Arg
Human HSF1-5085H Recombinant Human HSF1 Protein, GST-tagged Wheat Germ GST
Human HSF1-339HCL Recombinant Human HSF1 lysate HEK293 N/A
Human HSF1-3369H Recombinant Human HSF1 Protein (Val15-Pro288), His tagged E.coli His Val15-Pro288
Human HSF1-3964H Recombinant Human HSF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSF1-2127H Recombinant Human HSF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSF1-3887HF Recombinant Full Length Human HSF1 Protein, GST-tagged In Vitro Cell Free System GST 529 amino acids
Mouse Hsf1-1183M Recombinant Mouse Hsf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish HSF1-9140Z Recombinant Zebrafish HSF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSF1 Related Articles
  • HSF1 Related Research Area

HSF1 involved in several pathways and played different roles in them. We selected most pathways HSF1 participated on our site, such as Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LegionellosisItgam&Itgb2;HSPA2;CASP7;TLR5;NAIP1;CLK1;IL12B;CXCL1;NFKBIA

HSF1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSF1 itself. We selected most functions HSF1 had, and list some proteins which have the same functions with HSF1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingDLX5;BATF3;AEBP2;TFAP2E;CC2D1A;DDIT3;MEF2A;NKX2-5;BCL11A
RNA polymerase II intronic transcription regulatory region sequence-specific DNA bindingHSF1;ZNF350;ZC3H8;VAX1;HSF2;NCOA2;VAX2;SMYD3
protein bindingNBL1;SYVN1;RYR1B;KCNE4;COMMD9;TMEM190;SEMA4C;SPSB4;ZBTB1
transcription factor activity, sequence-specific DNA bindingMYCH;KDM5A;UBP1;RXRGA;ZNF334;SNAPC5;NKX2-5;HOXB4;TTC4
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingHELT;NKX3-2;NFATC2;SNAI1;NFIL3-5;HINFP;CREBBP;FOXO1;TCF21

HSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSF1.

MAPKAPK2; PRKCQ; MINK1; YWHAE; saicar; PKM; CDK6; EEF1G; Prkaa1; IER5; TTC5; Zwint; STUB1

Ishida, K; Varrecchia, M; et al. Immunolocalization of Anti-Hsf1 to the Acetabular Glands of Infectious Schistosomes Suggests a Non-Transcriptional Function for This Transcriptional Activator. PLOS NEGLECTED TROPICAL DISEASES 8:-(2014).
Zhao, RZ; Ren, S; et al. Involvement of fibrinolytic regulators in adhesion of monocytes to vascular endothelial cells induced by glycated LDL and to aorta from diabetic mice. JOURNAL OF LEUKOCYTE BIOLOGY 95:941-949(2014).
  • Q&As
  • Reviews

Q&As (7)

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In which cellular compartments is HSF1 predominantly localized? 10/06/2022

HSF1 is predominantly localized in the cytoplasm of cells, and it undergoes nuclear translocation upon activation.

What role does HSF1 play in the regulation of protein homeostasis and the heat shock response? 07/14/2022

The role of HSF1 includes regulating protein homeostasis and the heat shock response, ensuring cellular proteostasis.

What diseases or conditions are associated with dysregulation or abnormal expression of HSF1? 11/07/2020

Dysregulation or abnormal expression of HSF1 is associated with conditions such as cancer, neurodegenerative disorders, and metabolic diseases.

How does HSF1 influence cellular processes such as apoptosis and senescence? 06/07/2020

HSF1 influences cellular processes such as apoptosis and senescence, playing a role in cell fate decisions under stress conditions.

What is the primary function of heat shock factor 1 (HSF1) in cellular stress responses? 02/21/2018

Heat shock factor 1 (HSF1) primarily functions in cellular stress responses, orchestrating the heat shock response.

Are there therapeutic implications or potential targets related to HSF1 in diseases involving cellular stress? 12/19/2017

There are potential therapeutic implications related to HSF1 in diseases involving cellular stress, making it a target for drug development.

How does HSF1 become activated in response to cellular stress, and what are its target genes? 07/03/2016

HSF1 becomes activated in response to cellular stress, such as heat shock, and it induces the expression of heat shock proteins.

Customer Reviews (3)

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Reviews
08/30/2021

    The manufacturer's commitment to open science principles resonated with our lab's dedication to transparent research.

    12/17/2018

      We valued the educational webinars and documentation that enhanced our team's proficiency in utilizing the product.

      12/16/2017

        Its association with impactful research publications contributed to its reputation as a valuable scientific tool.

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