HSPA9
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Official Full Name
heat shock 70kDa protein 9 (mortalin)
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Overview
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2. -
Synonyms
HSPA9; heat shock 70kDa protein 9 (mortalin)provided by HGNC; CSA; MOT; MOT2; GRP75; PBP74; GRP-75; HSPA9B; MGC4500; MTHSP75; stress-70 protein, mitochondrial; heat shock 70kDa protein 9 (mortalin);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
HSPA9 involved in several pathways and played different roles in them. We selected most pathways HSPA9 participated on our site, such as RNA degradation, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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RNA degradation | DCP2;TOB2;PABPC1L;WDR61;LSM2;ENO1B;LSM3;TOB1A;PABPC3 |
Tuberculosis | RAB7A;CD209C;TNF;RELA;RAB5B;IFNA14;CASP10;FCGR1;IFNA16 |
HSPA9 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA9 itself. We selected most functions HSPA9 had, and list some proteins which have the same functions with HSPA9. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | NLRP4;ERBB2;NAV2;ABCB4;ATM;NME1;EGFR;DNAJA3A;MAK |
fibroblast growth factor binding | PTPRZ1;FGFR3;RPS2;FGFBP1;S100A13;SCN5A;FGFR1;HSPA9;FGFR2 |
heat shock protein binding | HDAC2;NFKBIA;HSPA6;DNAJB6;LIMK1;BCOR;CDC37L1;DNAJA4;DNAJA3A |
poly(A) RNA binding | RPL5A;CHERP;SLIRP;RBM12B;PUS1;BTF3;SUMO1;HIST1H4M;ZC3H8 |
protein binding | SEPT3;SPATA13;BAZ2A;GRN;CEP68;STRA13;AGT;ANO6;UFD1L |
ubiquitin protein ligase binding | CUL4B;PRKAR2B;WASH1;CUL1B;TRAF5;UBE2R2;TUBB;IKBKG;RB1 |
unfolded protein binding | DNAJA4;DNAJB11;CRYAA;PPIA;TRAP1;DNAJA2L;LRPAP1;SSUH2.2;AIPL1 |
HSPA9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA9 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA9.
TP53; EGFR; TP73
- Q&As
- Reviews
Q&As (7)
Ask a questionEnvironmental stressors like heat shock and toxins alter HSPA9 expression, impacting its protective roles in cells.
HSPA9 influences immune cell functionality and modulates inflammatory responses, impacting immune regulation.
HSPA9 is implicated in neurodegenerative diseases, potentially affecting protein misfolding and mitochondrial dysfunction.
Dysregulation of HSPA9 can lead to enhanced cancer cell proliferation and survival, affecting tumor growth.
HSPA9 plays a role in cellular aging by influencing mitochondrial function and stress response mechanisms.
HSPA9 cooperates with other chaperones in protein folding and prevents harmful protein aggregation.
HSPA9 is essential for mitochondrial function and helps cells respond to stress by regulating mitochondrial integrity and signaling.
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