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HSPA9

  • Official Full Name

    heat shock 70kDa protein 9 (mortalin)

  • Overview

    This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.
  • Synonyms

    HSPA9; heat shock 70kDa protein 9 (mortalin)provided by HGNC; CSA; MOT; MOT2; GRP75; PBP74; GRP-75; HSPA9B; MGC4500; MTHSP75; stress-70 protein, mitochondrial; heat shock 70kDa protein 9 (mortalin);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA9-13989H Recombinant Human HSPA9, GST-tagged E.coli GST 331-679a.a.
Human HSPA9-4852H Recombinant Human Heat Shock 70kDa Protein 9 (mortalin), GST-tagged Sf9 Insect Cell GST
Human HSPA9-29142TH Recombinant Human HSPA9, His-tagged E.coli His
Human HSPA9-26821TH Recombinant Human HSPA9 E.coli N/A
Human HSPA9-334H Recombinant Human Heat Shock 70kDa Protein 9 (Mortalin), His-tagged E.coli His
Human HSPA9-5113H Recombinant Human HSPA9 Protein, GST-tagged Wheat Germ GST
Human HSPA9-5352HCL Recombinant Human HSPA9 293 Cell Lysate HEK293 N/A
Human HspA9-050H Recombinant Human HspA9 Protein, N-His-tagged E.coli N-His 679
Human HSPA9-477HFL Recombinant Full Length Human HSPA9 Protein, C-Flag-tagged Mammalian cells Flag
Human HSPA9-3963HF Recombinant Full Length Human HSPA9 Protein, GST-tagged In Vitro Cell Free System GST 679 amino acids
Human HSPA9-1122H Recombinant Human HSPA9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPA9-3250H Recombinant Human HSPA9 Protein (Ser65-Ala311), N-His tagged E.coli N-His Ser65-Ala311
Human HSPA9-1122H-B Recombinant Human HSPA9 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSPA9-7912M Recombinant Mouse HSPA9 Protein Mammalian Cell His
Mouse HSPA9-4359M-B Recombinant Mouse HSPA9 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSPA9-4359M Recombinant Mouse HSPA9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hspa9-1192M Recombinant Mouse Hspa9 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish HSPA9-11473Z Recombinant Zebrafish HSPA9 Mammalian Cell His
Chicken HSPA9-1299C Recombinant Chicken HSPA9 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HSPA9 involved in several pathways and played different roles in them. We selected most pathways HSPA9 participated on our site, such as RNA degradation, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationDCP2;TOB2;PABPC1L;WDR61;LSM2;ENO1B;LSM3;TOB1A;PABPC3
TuberculosisRAB7A;CD209C;TNF;RELA;RAB5B;IFNA14;CASP10;FCGR1;IFNA16

HSPA9 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA9 itself. We selected most functions HSPA9 had, and list some proteins which have the same functions with HSPA9. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP4;ERBB2;NAV2;ABCB4;ATM;NME1;EGFR;DNAJA3A;MAK
fibroblast growth factor bindingPTPRZ1;FGFR3;RPS2;FGFBP1;S100A13;SCN5A;FGFR1;HSPA9;FGFR2
heat shock protein bindingHDAC2;NFKBIA;HSPA6;DNAJB6;LIMK1;BCOR;CDC37L1;DNAJA4;DNAJA3A
poly(A) RNA bindingRPL5A;CHERP;SLIRP;RBM12B;PUS1;BTF3;SUMO1;HIST1H4M;ZC3H8
protein bindingSEPT3;SPATA13;BAZ2A;GRN;CEP68;STRA13;AGT;ANO6;UFD1L
ubiquitin protein ligase bindingCUL4B;PRKAR2B;WASH1;CUL1B;TRAF5;UBE2R2;TUBB;IKBKG;RB1
unfolded protein bindingDNAJA4;DNAJB11;CRYAA;PPIA;TRAP1;DNAJA2L;LRPAP1;SSUH2.2;AIPL1

HSPA9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA9 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA9.

TP53; EGFR; TP73

  • Q&As
  • Reviews

Q&As (7)

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How do environmental factors like heat shock and toxins affect the expression and function of HSPA9? 07/06/2022

Environmental stressors like heat shock and toxins alter HSPA9 expression, impacting its protective roles in cells.

How does HSPA9 influence immune cell function and inflammatory responses? 05/06/2022

HSPA9 influences immune cell functionality and modulates inflammatory responses, impacting immune regulation.

What role does HSPA9 play in the pathogenesis of neurodegenerative diseases, such as Parkinson's and Alzheimer's? 03/13/2022

HSPA9 is implicated in neurodegenerative diseases, potentially affecting protein misfolding and mitochondrial dysfunction.

What is the impact of HSPA9 dysregulation on cancer cell proliferation and survival? 09/24/2020

Dysregulation of HSPA9 can lead to enhanced cancer cell proliferation and survival, affecting tumor growth.

What are the mechanisms by which HSPA9 contributes to the cellular aging process? 11/19/2019

HSPA9 plays a role in cellular aging by influencing mitochondrial function and stress response mechanisms.

How does HSPA9 interact with other molecular chaperones in protein folding and prevention of protein aggregation? 10/21/2019

HSPA9 cooperates with other chaperones in protein folding and prevents harmful protein aggregation.

How does HSPA9 regulate mitochondrial function and cellular stress responses? 09/30/2018

HSPA9 is essential for mitochondrial function and helps cells respond to stress by regulating mitochondrial integrity and signaling.

Customer Reviews (3)

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Reviews
11/01/2019

    Quick and reliable protein sequencing; invaluable for our work.

    05/05/2019

      High-quality protein crystallography services; exceptional results.

      11/16/2018

        Critical expertise in protein engineering; unmatched service quality.

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