ict1
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  • Official Full Name
  • immature colon carcinoma transcript 1
  • Background
  • The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells.
  • Synonyms
  • ICT1; immature colon carcinoma transcript 1; peptidyl-tRNA hydrolase ICT1, mitochondrial; DS 1; Digestion substraction 1; DS1; Immature colon carcinoma transcript 1 protein; DS-1
Cat.#:ICT1-395HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human immature colon carcinoma transcript 1, His-tagged
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Cat.#:ICT1-7978MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ICT1 Protein
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Cat.#:ICT1-5313HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ICT1 293 Cell Lysate
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Involved Pathway

ICT1 involved in several pathways and played different roles in them. We selected most pathways ICT1 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICT1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mitochondrial translation
DAP3; MRPL40; AURKAIP1; MRPL45; TUFM; CHCHD1; MRPS33; MTIF3; MRPS23; MRPL39
Mitochondrial translation elongation
MRPL51; MRPL45; MRPS30; MRPS36; MRPL53; MRPS27; MRPL55; MRPL44; DAP3; MRPS24
Mitochondrial translation initiation
ICT1; MRPL47; MRPS36; MRPS25; DAP3; MRPS26; MRPS30; MRPL44; MRPL51; MRPL53
Mitochondrial translation termination
PTCD3; MRPL50; MRPL51; CHCHD1; MRPL53; MRPS23; GFM2; MRPL44; MRPL54; MRPL48
Organelle biogenesis and maintenance
MRPL54; PTCD3; TTC26; MRPS31; ARL3; BBS12; MRPS28; MRPL37; POLRMT; IFT122

Protein Function

ICT1 has several biochemical functions, for example, aminoacyl-tRNA hydrolase activity, ribosome binding, translation release factor activity, codon nonspecific. Some of the functions are cooperated with other proteins, some of the functions could acted by ICT1 itself. We selected most functions ICT1 had, and list some proteins which have the same functions with ICT1. You can find most of the proteins on our site.
Function
Related Protein
Function aminoacyl-tRNA hydrolase activity
Related Protein PTRH1; PTRH2; PTRHD1; C12orf65; ICT1
Function ribosome binding
Related Protein OLA1; ETF1; WIBG; EIF2S1; CPEB2; MTRF1; RPN2; RPSA; EIF2A; CPEB3
Function translation release factor activity, codon nonspecific
Related Protein ICT1; C12orf65
Function NOT translation release factor activity, codon specific
Related Protein ICT1; C12orf65

Interacting Protein

ICT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICT1.
MRPL3; DAP3; MRPL12; MCC; VHL; GTPBP10; MRPL38; a6nle7_human; grsf1; slc25a6; nipsnap1; sdha; oxa1l; mrps31; immt