ifna21
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  • Official Full Name
  • interferon, alpha 21
  • Background
  • This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus.
  • Synonyms
  • IFNA21; interferon, alpha 21; interferon alpha-21; IFN alphaI; leukocyte interferon protein; Interferon alpha F; LeIF F; MGC126687; MGC126689; IFN-alpha-21; interferon alpha-F; leIF-F; IFN-alphaI
Cat.#:IFNA21-1424HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNA21 Protein (24-189 aa), His-tagged
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Cat.#:IFNA21-617HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNA21 Protein, His/GST-tagged
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Cat.#:IFNA21-77HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon, Alpha 21
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Cat.#:IFNA21-41HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon, Alpha 21
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Cat.#:IFNA21-140HTag:N/A
Source (Host):SPF chicken eggsSpecies:Human
Product nameRecombinant Human Interferon, Alpha 21
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Cat.#:IFNA21-5280HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNA21 293 Cell Lysate
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Involved Pathway

IFNA21 involved in several pathways and played different roles in them. We selected most pathways IFNA21 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL5; CXCL13; CCR9A; CSF1R; INHBB; ACVR1; VEGFA; IL12B; TNFRSF19; TNFRSF11B
Regulation of autophagy
INS2; IFNA13; PIK3R4; PRKAA1; INSB; IFNA17; IFNA2; ATG13; Ifna15; GABARAPL1
PIK-Akt signaling pathway
IFNAR2; PDGFB; IFNA2; GNG12; PDGFA; MAPK3; FGF5; NFKB1; GNG11; LAMA3
Toll-like receptor signaling pathway
IKBKE; TBK1; PIK3R1; IFNA17; MAPK14A; MAPK12A; IFNA2; TLR9; RAC1; IKBKB
RIG-I-like receptor signaling pathway
IL12B; TBK1; MAP3K7; IL8L2; IFNA3; CASP8; IKBKE; CXCL8B.3; IFNB; SIKE1
Cytosolic DNA-sensing pathway
IFNA17; IFNPHI3; IFNA5; IKBKE; POLR2F; POLR1D; IFNA14; IKBKB; POLR3F; IFNA1
Jak-STAT signaling pathway
IL22RA2; IFNA3; STAT3; IFNA7; GM-CSF; Ifnlr1; PTPN2B; IFNGR1; IFNA17; RAF1A
Natural killer cell mediated cytotoxicity
MAPK1; SAMD3; Casp3; KIR3DL1; IFNAR1; KRAS; BID; PRKCA; IFNA17; IFNA14
Tuberculosis
SYK; LBP; IFNA2; CLEC7A; H2-AB1; FCGR3A; CALM3; NFYB; LSP1; cgr2b
Hepatitis C
BAD; CLDN10; OCLN; IFNA21; PPP2R2B; MAPK13; PPP2R2A; IFNA2; SOS1; CLDN15
Hepatitis B
CCNA1; TGFB3; IFNB1; CCNE2; MMP9; ELK1; PIK3CD; VDAC3; IFNA5; RAF1
Measles
CCND3; CCNE1; CD28; MSN; IFNB1; MYD88; PIK3R2; TP53; IL13; TNFRSF10C
Influenza A
TMPRSS13; TNFRSF1A; TYK2; DNAJB1; IFNA1; IFNA10; FDPS; PLG; TLR7; MAVS
Herpes simplex infection
LOC100033925; JAK2B; MAPK10; SRSF1A; SRSF9; IFNAR2; IFNB1; CCL2; SRSF7B; STAT1
Autoi
TSHR; CD40LG; IFNA16; HLA-E; Fasl; PRF1; CD40; IFNA10; HLA-DOA; IFNA21
ne thyroid disease
TPO; HLA-E; HLA-DMB; IFNA8; CD28; CD86; Ifna15; HLA-DRA; H2-Q10; H2-AA

Protein Function

IFNA21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA21 itself. We selected most functions IFNA21 had, and list some proteins which have the same functions with IFNA21. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GREM2; IL32; IL17F; CSF2; VSTM1; BMP10; SECTM1; IL29; LEFTY1; IFNT2
Function cytokine receptor binding
Related Protein IL17A/F3; IL17C; IFNPHI4; IFNA8; IFNA3; IFNPHI2; IFNA14; MIF; IFNT2; IL17A/F1
Function type I interferon receptor binding
Related Protein Ifna15; GM13289; GM13278; GM13288; IFNA12; RNF207B; IFNA10; OSTN; IFNB; IFNA16

IFNA21 Related Articles

Guo, YL; Gao, MC; et al. Molecular cloning and characterization of a novel bovine IFN-epsilon. GENE 558:25-30(2015).
Liu, R; Huang, DD; et al. Immunization with Recombinant SFTSV/NSs Protein Does Not Promote Virus Clearance in SFTSV-Infected C57BL/6J Mice. VIRAL IMMUNOLOGY 28:113-122(2015).