impa2
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  • Official Full Name
  • inositol(myo)-1(or 4)-monophosphatase 2
  • Background
  • This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
  • Synonyms
  • IMPA2; inositol(myo)-1(or 4)-monophosphatase 2; inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; myo-inositol monophosphatase A2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2;
Cat.#:IMPA2-5143HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IMPA2 Protein, GST-tagged
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Cat.#:IMPA2-29492THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA2, His-tagged
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Cat.#:IMPA2-3454HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA2 protein, His-tagged
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Cat.#:IMPA2-3057RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IMPA2 Protein
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Cat.#:IMPA2-2264RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IMPA2 Protein, His-tagged
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Cat.#:IMPA2-2755ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IMPA2
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Cat.#:IMPA2-5213HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IMPA2 293 Cell Lysate
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Involved Pathway

IMPA2 involved in several pathways and played different roles in them. We selected most pathways IMPA2 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
TPI1A; ITPK1A; SYNJ2; PI4KAA; PTEN; IPMKB; PLCZ1; NUDT4; PLCD1; MTMR7A
Metabolic pathways
NAPRT; ACSL4A; TDO2; ATP6V1D; MTMR1; PCYT1BB; ALDOB; AK5; NDUFS8B; ALDH2
Phosphatidylinositol signaling system
PLCD3; IMPA2; PI4KB; PLCD1B; MTMR1; PTEN; PIP4K2AA; PIK3R3; MTMR4; CDS2

Protein Function

IMPA2 has several biochemical functions, for example, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA2 itself. We selected most functions IMPA2 had, and list some proteins which have the same functions with IMPA2. You can find most of the proteins on our site.
Function
Related Protein
Function inositol monophosphate 1-phosphatase activity
Related Protein IMPAD1; IMPA2; IMPA1
Function inositol monophosphate 3-phosphatase activity
Related Protein IMPAD1; IMPA2; IMPA1
Function inositol monophosphate 4-phosphatase activity
Related Protein IMPAD1; IMPA1; IMPA2
Function magnesium ion binding
Related Protein RPS6KA2; FOXK2; STK11; SIK2; TSSK1; FDXACB1; ENO1B; RPS6KA1; ZNF143B; PPA1
Function protein binding
Related Protein TPD52L1; RAD52; LMO4; ATG13; CBR4; EML1; TUBA4A; C10orf35; CAV3; CD99L2
Function protein homodimerization activity
Related Protein JUP; NTRK2; TCF12; PTPRO; CCBL2; CADM1B; DMRTB1; MTERFD3; PDXK; PYGL

Interacting Protein

IMPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA2.
IMPA1; UBA3; CCT6A; HERPUD1; q8ckm5_yerpe; TNFRSF14

IMPA2 Related Articles

Ohnishi, T; Murata, T; et al. Defective Craniofacial Development and Brain Function in a Mouse Model for Depletion of Intracellular Inositol Synthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10785-10796(2014).
Jimenez, E; Arias, B; et al. Genetic variability at IMPA2, INPP1 and GSK3 beta increases the risk of suicidal behavior in bipolar patients. EUROPEAN NEUROPSYCHOPHARMACOLOGY 23:1452-1462(2013).