• Official Full Name
  • integrator complex subunit 3
  • Background
  • INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large;subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2;(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)). INTS3 is also a subunit of single-stranded DNA;(ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) (PubMed;19683501).
  • Synonyms
  • INTS3; integrator complex subunit 3; C1orf60, chromosome 1 open reading frame 60; FLJ21919; INT3; C1orf193; C1orf60; INT 3; SOSS complex subunit A; RP11-216N14.4; sensor of ssDNA A; OTTHUMP00000035161; OTTHUMP00000038687; OTTHUMP00000222672; sensor of ssDNA subunit A; sensor of single-strand DNA complex subunit A; SOSS-A; RP11-216N14.2
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INTS3 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INTS3, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INTS3 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish INTS3

Protein Function

INTS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INTS3 itself. We selected most functions INTS3 had, and list some proteins which have the same functions with INTS3. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein STMN2; POU1F1; PLK1; SYNE1; RIPPLY1; AGXT; JUP; LRCH3; ADCK5; KIAA0408

Interacting Protein

INTS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INTS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of INTS3.
ZBTB14; UBA1; UBE2N; UBE2V1; NFKB1; ssdna_dadc; E2F3; p27958-pro_0000037566; SNW1; CDC5L

INTS3 Related Articles

Skaar, JR; Ferris, AL; et al. The Integrator complex controls the termination of transcription at diverse classes of gene targets. CELL RESEARCH 25:288-305(2015).
Stadelmayer, B; Micas, G; et al. Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes. NATURE COMMUNICATIONS 5:-(2014).