irf9
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  • Official Full Name
  • interferon regulatory factor 9
  • Background
  • Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Synonyms
  • IRF9; interferon regulatory factor 9; interferon stimulated transcription factor 3, gamma (48kD) , interferon stimulated transcription factor 3, gamma 48kDa , ISGF3G; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcripti
Cat.#:IRF9-5016HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF9 Protein, GST-tagged
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Cat.#:IRF9-630CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IRF9 Protein, His-tagged
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Cat.#:IRF9-2302RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF9 Protein, His-tagged
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Cat.#:IRF9-11731ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF9
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Cat.#:IRF9-5158HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF9 293 Cell Lysate
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Involved Pathway

IRF9 involved in several pathways and played different roles in them. We selected most pathways IRF9 participated on our site, such as Cytokine Signaling in Immune system, Hepatitis C, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine Signaling in Immune system
SPTBN2; PEBP1; EIF4E3; NRG4; TRIM31; SPTB; IFI27; FRS2B; IFI6; SPTBN1
Hepatitis C
RELA; PPP2R2C; CLDN8; SOS1; CLDN15; STAT2; EIF3E; TRAF6; SCARB1; IKBKB
Herpes simplex infection
POU2F3; SRPK1; BMA2; OAS2; HLA-G; BF1; SRSF5B; C3A.2; HLA-E; PER1A
IFN-gamma pathway
IRF9; DAPK1
Immune System
DEFB106A; Txn1; DEFB4B; CTSO; KIFAP3; PELI3; SOCS3A; GBP4; RNF14; TXNIP
Influenza A
GSK3B; PLG; HLA-DOA; PIK3R5; PYCARD; Ifna11; HSPA6; IFNGR2; IFNAR1; MAPK3
Interferon Signaling
ARIH1L; GBP6; IRF2; TRIM62; TRIM46; TRIM14; IFIT11; IFIT14; TRIM31; TRIM5
Interferon alpha/beta signaling
IFI6; XAF1; BST2; ISG20; IRF2; GBP2; IFITM2; IRF4; OASL; IFI35

Protein Function

IRF9 has several biochemical functions, for example, core promoter binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF9 itself. We selected most functions IRF9 had, and list some proteins which have the same functions with IRF9. You can find most of the proteins on our site.
Function
Related Protein
Function core promoter binding
Related Protein E2F7; XBP1; AGO2; ARNTL; MTA1; E2F1; NKX3-1; PSPC1; IFI16; MYOD1
Function protein binding
Related Protein SNRPD2; DCAF12L1; CD37; HAND1; MOBKL2B; NFKBID; CATSPER1; SLC6A12; RPL7; ALAS1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SOX4; IRF3; NKX2-1; TBX18; RARGA; SIX4; NR2F1; PBX1; NR5A5; LBX1

Interacting Protein

IRF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF9.
STAT2; IFNAR2; STAT1; MYO1F; uvrA; S100A13; pi3p

IRF9 Related Articles

Erb, HHH; Langlechner, RV; et al. IL6 sensitizes prostate cancer to the antiproliferative effect of IFN alpha(2) through IRF9. ENDOCRINE-RELATED CANCER 20:677-689(2013).
Colonne, PM; Sahni, A; et al. Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. JOURNAL OF MEDICAL MICROBIOLOGY 62:968-979(2013).