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  • Official Full Name
  • itchy E3 ubiquitin protein ligase
  • Background
  • This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
  • Synonyms
  • ITCH; itchy E3 ubiquitin protein ligase; AIF4; AIP4; NAPP1; dJ468O1.1; E3 ubiquitin-protein ligase Itchy homolog; NFE2-associated polypeptide 1; atrophin-1 interacting protein 4; itchy E3 ubiquitin protein ligase homolog; dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4));
Cat.#:ITCH-5004HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITCH Protein, GST-tagged
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Cat.#:ITCH-3094HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITCH, None tagged
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Cat.#:ITCH-8480ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITCH
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Cat.#:ITCH-5141HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITCH 293 Cell Lysate
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Involved Pathway

ITCH involved in several pathways and played different roles in them. We selected most pathways ITCH participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
PIAS2; CDC26; CDC20; UBA2; CDC34A; UBE2NA; MGRN1B; FBXW11; CDC27; UBE2E1
Endocytosis
ARPC1B; KIT; PARD6A; HLA-C; PSD3; CHMP4A; GRK6; PML; SNX6; PIP5K1AA
TNF signaling pathway
MAPK12; IL18R1; Ccl12; CASP7; TAB2; SELE; TRADD; MMP9; TRAF1; CXCL3
Non-alcoholic fatty liver disease (NAFLD)
UQCRC2; SOCS3; MLXIPL; IL1A; Fasl; UQCRFS1; NDUFA4; FASLG; MAPK10; RELA

Protein Function

ITCH has several biochemical functions, for example, CXCR chemokine receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITCH itself. We selected most functions ITCH had, and list some proteins which have the same functions with ITCH. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein CXCL3; CXCL12B; PF4V1; CXCL6; CXCL12A; IL8L2; CXCL2; ITCH; CXCL5; CXCL1
Function ligase activity
Related Protein LIG4; TRIM22; RNF4; IRF2BP1; TRIM58; RNF169; RNF152; TTLL9; GLULA; UBE2D1A
Function protein binding
Related Protein RCAN3; RAD51C; HERC5; TMEM86B; SERPINF1; MIS12; ACE; CDCA5; MDFIC; SFRP4
Function ribonucleoprotein complex binding
Related Protein CD2BP2; PRPF31; PRPF6; PIGC; RNF135; CKAP5; PRMT5; TIMM50; BOP1; IFIH1
Function ubiquitin protein ligase activity
Related Protein NHLRC1; MED23; UBE2Z; SIAH2; UBE2N; BRAP; STUB1; PPIL2; AMFR; XIAP
Function ubiquitin-protein transferase activity
Related Protein FBXL14A; UBE2A; NHLRC1; FBXW11; MARCH8; RNF168; TRIM62; RNF11; ANKIB1; UHRF2

Interacting Protein

ITCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITCH here. Most of them are supplied by our site. Hope this information will be useful for your research of ITCH.
TP73; SGK3; SNX9; GLI1

ITCH Related Articles

Zandberg, DP; Rollins, S; et al. A phase I dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). CANCER IMMUNOLOGY IMMUNOTHERAPY 64:367-379(2015).
Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).