Recombinant Human ITCH protein

• Cat.No.: ITCH-01H
• Product Overview: Recombinant Human ITCH protein was expressed in Bacterial.

Specification

• Species: Human
• Source: E.coli
• Description: ITCH, also called atrophin-1 interacting protein 4 (AIP4), is a HECT-type E3 ubiquitin ligase. It contains an N-terminal Ca-dependent phospholipid-binding C2 domain, four WW domains, and a C-terminal HECT domain. Mice deficient in ITCH protein display many autoimmune-like disease characteristics such as lymphoproliferation in the spleen and lymph nodes. More than a dozen of substrates of ITCH have been identified including p63, p73 and Notch1. The ligase may be responsible for ubiquitinating proteins with K29-, K48-, and/or K63-linked ubiquitin chains.
• Form: 20 mM Tris, 150 mM NaCl, 2 mM Βme, 10% Glycerol.
• Molecular Mass: 102.8 kDa
• Purity: ~90%
• Storage: Store at -80 centigrade; avoid multiple freeze-thaw cycles.
• Shipping: Dry ice shipping

Gene Information

• Gene Name: ITCH itchy E3 ubiquitin protein ligase [ Homo sapiens (human) ]
• Official Symbol: ITCH
• Synonyms: AIF4; AIP4; NAPP1; dJ468O1.1
• Gene ID: 83737
• mRNA Refseq: NM_001257137
• Protein Refseq: NP_001244066
• MIM: 606409
• UniProt ID: Q96J02