• Official Full Name
  • IWS1 homolog
  • Background
  • Various steps in gene expression, such as mRNA processing, surveillance, export, and synthesis are coupled to transcription elongation. The C-terminal domain (CTD) of the large subunit of RNA polymerase II plays an important role in the integration of the
  • Synonyms
  • IWS1; IWS1 homolog (S. cerevisiae); protein IWS1 homolog; DKFZp761G0123; FLJ10006; FLJ14655; FLJ32319; IWS1-like protein; interacts with Spt6; MGC126375; MGC126376
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IWS1 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IWS1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IWS1 Protein

Involved Pathway

IWS1 involved in several pathways and played different roles in them. We selected most pathways IWS1 participated on our site, such as Proteasome Degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IWS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome Degradation

Protein Function

IWS1 has several biochemical functions, for example, peptidase activity, protein binding, ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IWS1 itself. We selected most functions IWS1 had, and list some proteins which have the same functions with IWS1. You can find most of the proteins on our site.
Related Protein
Function peptidase activity
Related Protein F2RL1.1; CTSL1B; OTUD5A; ASTL; PRSS59.1; HE1A; CTSB; KLK1B9; MASP1; KLK1B22
Function protein binding
Related Protein INO80E; PKD1L3; HDDC3; AKIP1; MRAS; GPSM3; PBRM1; DUSP14; TXNDC11; SNRPD1
Function ubiquitin binding
Related Protein MARK4; CXCR4; NBR1; USP25; FAF2; NSFL1C; SQSTM1; FAF1; RNF31; CRY1
Function ubiquitin-specific protease activity
Related Protein BRCC3; USP42; OTUD7B; USP6; USP33; UCHL5; CYLD; USP16; STAMBP; UCHL1

Interacting Protein

IWS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IWS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IWS1.

IWS1 Related Articles

Gerard, A; Segeral, E; et al. The Integrase Cofactor LEDGF/p75 Associates with Iws1 and Spt6 for Postintegration Silencing of HIV-1 Gene Expression in Latently Infected Cells. CELL HOST & MICROBE 17:107-117(2015).
Wang, XL; Chen, JN; et al. Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana. MOLECULAR PLANT 7:1303-1315(2014).