kcnq1
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  • Official Full Name
  • Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1
  • Background
  • The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel (also known as KvLQT1). Mutations in KCNQ1 cause an inherited form of long QT syndrome, type 1. KCNQ1 channels expressed in the heart are anti-targets in cardiac risk assessment.
  • Synonyms
  • KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; FLJ26167; OTTHUMP00000011540; OTTHUMP00000011587; KCNQ1 Potassium Channel
Cat.#:KCNQ1-8546MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNQ1 Protein
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Cat.#:KCNQ1-3221RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNQ1 Protein
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Cat.#:KCNQ1-6648ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KCNQ1
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Cat.#:KCNQ1-5020HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KCNQ1 293 Cell Lysate
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Involved Pathway

KCNQ1 involved in several pathways and played different roles in them. We selected most pathways KCNQ1 participated on our site, such as Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
PIK3R5; PIK3R1; ADCY6; PLCB3; CACNA2D3; SCN5A; PIK3R3B; ATP2B1A; ADRB3B; PLCB2
Cholinergic synapse
ITPR1; KCNJ14; GNG10; PIK3R2; GNG13; GNB1; CAMK2G; PIK3CG; PIK3R1; KCNJ6
Gastric acid secretion
KCNE2; PLCB3; CALM2; EZR; PLCB4; GNAS; ATP4A; CAMK2G; KCNK2; CALM3
Neuronal System
KCNH8; STXBP1A; SLC1A7B; KCNK2; UNC13B; SYT1A; KCNC2; KCNQ3; KCNS3A; KCNK2B
Pancreatic secretion
SCTR; ATP1B3; ATP2A1; RAB11A; GNAS; SLC26A3; Car2; CD38; PLA2G2A; CTRL
Potassium Channels
KCNC2; KCNH2; KCNC3A; KCNC1B; KCNG1; KCNJ1A.5; ABCC9; KCNQ2; KCNH8; KCNH2A
Protein digestion and absorption
ATP1A1; COL13A1; ATP1A4; SLC8A1; SLC7A8; MEP1A; SLC1A1; SLC36A1; SLC38A2; ATP1A3
SIDS Susceptibility Pathways
GATA2; DEAF1; KCNJ8; PHOX2B; DLX2; PHOX2A; SCN3B; SST; ECE1; ASCL1

Protein Function

KCNQ1 has several biochemical functions, for example, calmodulin binding, delayed rectifier potassium channel activity, contributes_to delayed rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ1 itself. We selected most functions KCNQ1 had, and list some proteins which have the same functions with KCNQ1. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein PATE4; MYH11; DAPK2; MKNK2; RGS16; TRPV5; MYO1E; MARCKSB; RYR2; ATPIF1
Function delayed rectifier potassium channel activity
Related Protein KCNS3A; KCNC3B; KCNQ2; KCNA6; KCNA2; KCNC2; KCNH2; KCNC4; KCNQ4; KCNG2
Function contributes_to delayed rectifier potassium channel activity
Related Protein KCNE1; KCNQ1; KCNE2
Function ion channel binding
Related Protein CAV3; USP10; VDAC1; HERPUD1; ABCC9; ARRB1; GPD1L; KCNAB1; AP2M1; RNF207
Function outward rectifier potassium channel activity
Related Protein KCNK5B; KCNK2B; KCNK2; KCNB1; KCNQ1; REST; KCNK18; KCNA5; KCNK1A
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein ANXA8; LDLRAP1; TTPA; KCNJ1; TULP1; SCIN; ALOX15; RS1; TWF1; TIRAP
Function protein binding
Related Protein LNPEP; FLOT2; ARGLU1; ZFYVE19; ARF6; CNTNAP1; ATG4A; DCUN1D1; HSPA1B; LRRC47
Function protein kinase A catalytic subunit binding
Related Protein PRKAR2A; SOX9; RYR2; PKIA; KCNQ1; GSK3B; PJA2; PRKAR2B; PRKAR1B; PRKAR1A
Function protein kinase A regulatory subunit binding
Related Protein AKAP5; ARFGEF2; C2orf88; AKAP8; EZR; AKAP7; AKAP9; PJA2; RYR2; AKAP1
Function protein phosphatase 1 binding
Related Protein FER; PPP1R11; PHACTR3A; Fert2; PAWR; PPP1R9B; LILRB2; LILRB1; PHACTR3; PHACTR4B
Function scaffold protein binding
Related Protein NLGN4Y; IKBKB; KRT5; KCNQ1; KCNH2; SHANK1; KRT18; CHUK; MAP2K2; DLG4
Function voltage-gated potassium channel activity
Related Protein CNGA5; KCNV2B; KCNK5; KCNE3; KCNK9; KCNAB3; KCNMA1; KCNC1B; KCNS3A; KCNAB1
Function NOT voltage-gated potassium channel activity
Related Protein KCNK1; KCNQ1
Function contributes_to voltage-gated potassium channel activity
Related Protein KCNE1; KCNQ1; KCNE1L
Function voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
Related Protein KCNQ1; KCNA5
Function voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
Related Protein KCNJ2; KCNQ1
Function voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Related Protein KCNH2; KCNQ1; KCNE2

Interacting Protein

KCNQ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ1.
KCNE1; Akap9; CALM1; GRB2; TRAF6; AKAP9

KCNQ1 Related Articles

Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
Chadha, PS; Jepps, TA; et al. Contribution of Kv7.4/Kv7.5 Heteromers to Intrinsic and Calcitonin Gene-Related Peptide-Induced Cerebral Reactivity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:887-893(2014).