kcnq1
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  • Official Full Name
  • Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1
  • Background
  • The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel (also known as KvLQT1). Mutations in KCNQ1 cause an inherited form of long QT syndrome, type 1. KCNQ1 channels expressed in the heart are anti-targets in cardiac risk assessment.
  • Synonyms
  • KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; FLJ26167; OTTHUMP00000011540; OTTHUMP00000011587; KCNQ1 Potassium Channel
Cat.#:KCNQ1-8546MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNQ1 Protein
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Cat.#:KCNQ1-3221RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNQ1 Protein
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Cat.#:KCNQ1-6648ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KCNQ1
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Cat.#:KCNQ1-5020HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNQ1 293 Cell Lysate
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Cat.#:CSC-RI0144Tag:
Source (Host):Species:Human
Product nameHuman KCNQ1/KCNE1 Stable Cell Line-CHO
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Cat.#:CSC-RI0150Tag:
Source (Host):Species:Human
Product nameHuman KCNQ1/KCNE1 Stable Cell Line-CHO
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Involved Pathway

KCNQ1 involved in several pathways and played different roles in them. We selected most pathways KCNQ1 participated on our site, such as Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
CALM; CACNA1C; GNAS; PPP2R3C; CREB5; ATP1B1A; CACNG6; ADCY6; GNAI2A; ATP1B1
Cholinergic synapse
CHRM5; GNGT1; PIK3R5; KCNQ4; CHRNB2; GNG2; JAK2; CHRM1; CHRNA3; AKT1
Gastric acid secretion
KCNK2; ATP4B; SST; PLCB2; PRKCB; KCNJ1; Car2; PRKACB; CALM1; GNAQ
Neuronal System
CHRNA3; CCDC167; ARL6IP5; KCNA1; KCNN1; KCNC1; CHRNE; KCNH8; KCNJ1A.5; PPFIA1
Pancreatic secretion
ATP2A2; CCKAR; ATP1B2; PLA2G2D; PRSS1; CELA2A; RAB8A; CLCA3; ITPR1; TPCN2
Potassium Channels
KCNC1B; KCNJ1A.5; KCNA2; KCNC4; ABCC9; KCNH6A; KCNA6; KCNH1A; KCNJ1B; KCNF1A
Protein digestion and absorption
PRSS2; COL13A1; SLC3A2; SLC1A5; SLC7A8; COL10A1; CELA2A; PGA4; SLC8A2; ATP1A3
SIDS Susceptibility Pathways
POU3F2; CDCA7L; ECE1; KCNH2; SNTA1; SP3; TPH2; MAZ; KCNJ8; DEAF1

Protein Function

KCNQ1 has several biochemical functions, for example, calmodulin binding, delayed rectifier potassium channel activity, contributes_to delayed rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ1 itself. We selected most functions KCNQ1 had, and list some proteins which have the same functions with KCNQ1. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein MYLK; TRPV6; EEA1; MYO1D; MYH4; RYR2; GRIN1; MAPKAPK5; CAMK1GA; PLA2G6
Function delayed rectifier potassium channel activity
Related Protein KCNQ4; KCNA6; KCNH2; KCNB2; KCNA1; KCNC1B; KCNQ1; KCND1; KCNV1; KCNA2B
Function contributes_to delayed rectifier potassium channel activity
Related Protein KCNE1; KCNE2; KCNQ1
Function ion channel binding
Related Protein ACTN3; AASS; NOS1; FAM115C; ACTN4; BAK1; YES1; PPP1R9B; CAV1; PKD2
Function outward rectifier potassium channel activity
Related Protein REST; KCNK2; KCNK1A; KCNK5B; KCNK18; KCNQ1; KCNA5; KCNB1; KCNK2B
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein SYT1; JPH2; STXBP6; PARD3; Apba1; MYO1G; SNX18; ANXA2; SNX21; KLHL8
Function protein binding
Related Protein PHF7; CCBL1; SYTL2; CCDC42; TULP3; UBE2D3; MAB21L1; UBR2; FHL1; MYO7B
Function protein kinase A catalytic subunit binding
Related Protein RYR2; PRKAR2B; PRKAR1A; PRKAR2A; PJA2; PRKAR1B; GSK3A; GSK3B; KCNQ1; PKIA
Function protein kinase A regulatory subunit binding
Related Protein C2orf88; AKAP9; ARFGEF2; KCNQ1; PJA2; ARFGEF1; ACBD3; AKAP7; AKAP6; AKAP5
Function protein phosphatase 1 binding
Related Protein PAWR; PPP1R9B; LILRB1; PHACTR4; PPP1R15A; PPP1R11; KCNQ1; TCTEX1D4; PHACTR1; PHACTR3A
Function scaffold protein binding
Related Protein KRT5; NLGN4Y; CHUK; IKBKB; NLGN1; KRT15; CIT; CASP8; P2RY1; CACNA1G
Function voltage-gated potassium channel activity
Related Protein KCNQ2A; KCNH2A; KCNMA1A; KCNS3A; KCNAB1A; KCNA1; KCNH2; CNGA2; KCNC3A; KCNH5A
Function NOT voltage-gated potassium channel activity
Related Protein KCNK1; KCNQ1
Function contributes_to voltage-gated potassium channel activity
Related Protein KCNE1L; KCNE1; KCNQ1
Function voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
Related Protein KCNQ1; KCNA5
Function voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
Related Protein KCNJ2; KCNQ1
Function voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Related Protein KCNH2; KCNE2; KCNQ1

Interacting Protein

KCNQ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ1.
KCNE1; Akap9; CALM1; GRB2; TRAF6; AKAP9

KCNQ1 Related Articles

Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
Chadha, PS; Jepps, TA; et al. Contribution of Kv7.4/Kv7.5 Heteromers to Intrinsic and Calcitonin Gene-Related Peptide-Induced Cerebral Reactivity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:887-893(2014).