KCNQ1
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Official Full Name
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1
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Overview
The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel (also known as KvLQT1). Mutations in KCNQ1 cause an inherited form of long QT syndrome, type 1. KCNQ1 channels expressed in the heart are anti-targets in cardiac risk assessment. -
Synonyms
KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; FLJ26167; OTTHUMP00000011540; OTTHUMP00000011587; KCNQ1 Potassium Channel;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cavia porcellus (Guinea pig)
- Felis catus (Cat) (Felis silvestris catus)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Squalus acanthias (Spiny dogfish)
- Sus scrofa (Pig)
- Xenopus laevis (African clawed frog)
- Zebrafish
- E. coli
- E.coli expression system
- HEK293
- Mammalian Cell
- C
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- KCNQ1 Related Articles
KCNQ1 involved in several pathways and played different roles in them. We selected most pathways KCNQ1 participated on our site, such as Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | PIK3R1;PPP2CA;PPP2R5C;GNA11A;GNAI2;ADCY1B;CREB3;PPP1CAA;CREB3L3 |
| Cholinergic synapse | PRKACB;AKT2;PRKACA;GNGT2;MAPK3;CHRNB2;PIK3CB;CHRM2;GNAQ |
| Gastric acid secretion | Adcy4;PLCB1;KCNK2;ATP1B3;ATP1B4;PLCB4;KCNJ15;PRKACG;CAMK2A |
| Neuronal System | KCNJ11;KCNH5A;SLC17A7A;CHRNA3;LIN7A;AKAP5;BZRAP1;RAB3AA;Apba1 |
| Pancreatic secretion | PRSS3;Cel;PLA2G2D;GNAQ;CPA1;ATP2A1;RAP1A;CPB2;TRPC1 |
| Potassium Channels | KCNA4;KCNN1B;KCNA1;KCNH6A;KCNJ14;KCNAB3;KCNG1;KCNV1;KCNC3A |
| Protein digestion and absorption | COL10A1;ATP1B1;CELA3A;SLC36A1;COL24A1;COL6A5;COL21A1;ATP1B4;CPA1 |
| SIDS Susceptibility Pathways | PHOX2B;KCNJ8;LMX1B;RUNX3;EN1;IL1RN;KCNH2;ECE1;SCN3B |
KCNQ1 has several biochemical functions, for example, calmodulin binding, delayed rectifier potassium channel activity, contributes_to delayed rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ1 itself. We selected most functions KCNQ1 had, and list some proteins which have the same functions with KCNQ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | EDF1;CAMSAP1L1;MYO6;NETO2;ENKUR;SCN5A;MKNK2A;PATE4;UPF3B |
| delayed rectifier potassium channel activity | KCNQ3;KCNA6A;KCNA1;KCNA10;KCNV2;KCNV2B;KCNC1;KCNC4;KCNQ5 |
| contributes_to delayed rectifier potassium channel activity | KCNE2;KCNE1;KCNQ1 |
| ion channel binding | AASS;PACS2;NOS1;KCNE4;CIB1;FAM115C;KCNQ1;S100A10;PKP2 |
| outward rectifier potassium channel activity | REST;KCNK18;KCNK1A;KCNK5B;KCNQ1;KCNK2;KCNA5;KCNK2B;KCNB1 |
| phosphatidylinositol-4,5-bisphosphate binding | FCHO2;SNX21;RPH3A;LDLRAP1;FAM123B;STXBP6L;TWF1;CCDC167;EXOC1 |
| protein binding | COMMD2;FAF1;ACTN4;MAP2K6;DOCK10;PAN2;ZNF543;CNOT4;SHROOM2 |
| protein kinase A catalytic subunit binding | RYR2;PRKAR1B;PKIA;GSK3B;SOX9;PRKAR1A;CSK;PJA2;PRKAR2B |
| protein kinase A regulatory subunit binding | EZR;C2orf88;AKAP8;ARFGEF2;ACBD3;AKAP7;AKAP6;ARFGEF1;RYR2 |
| protein phosphatase 1 binding | PPP1R11;LILRB1;SH3RF2;PPP1R9B;FER;PPP1R15A;PHACTR3;SHOC2;TCTEX1D4 |
| scaffold protein binding | CHRNA7;DSP;DLG4;KRT5;PDE4D;CIT;SHANK3;MDM2;KCNQ1 |
| voltage-gated potassium channel activity | KCNQ5;KCNF1A;HCN4;CNGA5;KCNA2;KCNC3A;KCNMA1A;KCNC1B;KCNC1 |
| NOT voltage-gated potassium channel activity | KCNK1;KCNQ1 |
| contributes_to voltage-gated potassium channel activity | KCNQ1;KCNE1;KCNE1L |
| voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization | KCNQ1;KCNA5 |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | KCNQ1;KCNJ2 |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | KCNE2;KCNH2;KCNQ1 |
KCNQ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ1.
KCNE1; Akap9; CALM1; GRB2; TRAF6; AKAP9
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