kir2dl3
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  • Official Full Name
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
  • Background
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
  • Synonyms
  • KIR2DL3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; killer cell immunoglobulin-like receptor 2DL3; CD158B2; cl 6; nkat2; nkat2a; nkat2b; p58; CD158b; GL183; Killer Cell Immunoglobulin Like Receptor 2DL3; Killer inhibitory receptor CL2 3; KIR023GB; MHC Class I NK Cell Receptor; Natural Killer Associated Transcript 2; p58 Natural Killer Cell Receptor Clone CL6; p58 NK Receptor; p58.2 MHC Class I Specific NK Receptor; NKAT-2; NK-receptor; OTTHUMP00000068619; p58 NK receptor CL-6; killer inhibitory receptor cl 2-3; CD158 antigen-like family member B2; natural kill; NKAT; KIR-K7b; KIR-K7c; KIRCL23; KIR-023GB
Cat.#:KIR2DL3-146HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIR2DL3
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Cat.#:KIR2DL3-158HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL3, His-tagged
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Cat.#:KIR2DL3-164HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL3, Fc-tagged
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Cat.#:KIR2DL3-557HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human KIR2DL3, Fc-tagged, Biotinylated
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Cat.#:KIR2DL3-6968HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL3, His tagged
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Cat.#:KIR2DL3-8189HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIR2DL3 protein, His & GST-tagged
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Cat.#:KIR2DL3-1840HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL3 cell lysate
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Involved Pathway

KIR2DL3 involved in several pathways and played different roles in them. We selected most pathways KIR2DL3 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HLA-C; HLA-E; HLA-DOB; HSPA1L; HSPA6; H2-AA; KLRD1; KLRC1; HLA-DRA; HLA-DRB5
Natural killer cell mediated cytotoxicity
SOS1; FCGR4; RAET1G; IFNA14; NRAS; SH2D1B; HRAS; SH2D1A; IFNA4; NCR2
Graft-versus-host disease
IFNG; HLA-DQA2; KIR2DL1; HLA-DRB5; Il2; HLA-DRB3; HLA-DRB4; HLA-DPB1; CD28; HLA-DMB

Protein Function

KIR2DL3 has several biochemical functions, for example, antigen binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL3 itself. We selected most functions KIR2DL3 had, and list some proteins which have the same functions with KIR2DL3. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein IGLL1; TOPORS; IGKC; FCN2; SPON2; CD40; LCK; IL7R; IGLC2; HNRNPM
Function protein binding
Related Protein TTC8; NEU4; F10; HOOK2; SULT4A1; CLDN1; DCAF8; VTI1B; PHLDA1; ADCYAP1R1
Function receptor activity
Related Protein ANTXR2A; RAMP1; TLR2; OPN1SW; EDAR; PAQR9; CD93; ANXA2R; RTN4RL1; NRXN1

Interacting Protein

KIR2DL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL3.
PTPN6; PTPN11; Ptpn6

KIR2DL3 Related Articles

Guo, H; Xu, BC; et al. A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis-a pilot study. IMMUNOLOGICAL INVESTIGATIONS 43:312-323(2014).
Hilton, HG; Vago, L; et al. Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a More Refined but Less Adaptable NK Cell Receptor Than KIR2DL3. JOURNAL OF IMMUNOLOGY 189:1418-1430(2012).