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KIR2DL3

  • Official Full Name

    killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3

  • Overview

    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
  • Synonyms

    KIR2DL3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; killer cell immunoglobulin-like receptor 2DL3; CD158B2; cl 6; nkat2; nkat2a; nkat2b; p58; CD158b; GL183; Killer Cell Immunoglobulin Like Receptor 2DL3; Killer inhibitory receptor CL2 3; KIR023GB; MHC Class I NK Cell Receptor; Natural Killer Associated Transcript 2; p58 Natural Killer Cell Receptor Clone CL6; p58 NK Receptor; p58.2 MHC Class I Specific NK Receptor; NKAT-2; NK-receptor; OTTHUMP00000068619; p58 NK receptor CL-6; killer inhibitory receptor cl 2-3; CD158 antigen-like family member B2; natural kill; NKAT; KIR-K7b; KIR-K7c; KIRCL23; KIR-023GB;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian cells
  • C
  • Fc
  • His
  • hFc
  • His|GST
  • Avi
  • human|IgG1|Fc
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KIR2DL3-557H Active Recombinant Human KIR2DL3, Fc-tagged, Biotinylated Human Cell Fc
Human KIR2DL3-8189H Recombinant Human KIR2DL3 protein, His & GST-tagged E.coli His/GST His22~Pro341 (Accession # P43628)
Human KIR2DL3-158H Recombinant Human KIR2DL3 protein, His-tagged HEK293 His His22-His245
Human KIR2DL3-6968H Recombinant Human KIR2DL3 protein, His-tagged HEK293 His Met1-His245
Human KIR2DL3-146H Recombinant Human KIR2DL3 E.coli N/A
Human KIR2DL3-164H Recombinant Human KIR2DL3 protein, Fc-tagged HEK293 human/IgG1/Fc His22-His245
Human KIR2DL3-1840HCL Recombinant Human KIR2DL3 cell lysate Human Cell N/A
Human KIR2DL3-3240H Recombinant Human KIR2DL3 protein, His-tagged E.coli His 20-247 aa
Human KIR2DL3-804H Recombinant Human KIR2DL3 protein, His-Avi-tagged HEK293 His-Avi His 22-His 245
Human KIR2DL3-628HB Recombinant Human KIR2DL3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi His22-His245
Human KIR2DL3-1272H Active Recombinant Human KIR2DL3 protein, hFc&His-tagged HEK293 hFc&His His22-His245
Human KIR2DL3-340H Recombinant Human KIR2DL3 Protein, His-tagged HEK293 His 341
Human KIR2DL3-0323H Active Recombinant Human KIR2DL3 protein, Fc-tagged HEK293 Fc His22-His245
Human KIR2DL3-082H Recombinant Human KIR2DL3 Protein, C-His-tagged E.coli C-His
Human KIR2DL3-1315H Recombinant Human KIR2DL3 Protein (His22-Pro341), N-GST tagged E.coli N-GST His22-Pro341
Human KIR2DL3-341H Recombinant Human KIR2DL3 Protein, Fc-tagged HEK293 Fc 341
Human KIR2DL3-4339H Recombinant Human KIR2DL3 Protein (Met1-His245), C-Fc tagged Mammalian cells C-Fc Met1-His245
Human KIR2DL3-4338H Recombinant Human KIR2DL3 Protein (Met1-His245), C-His tagged Mammalian cells C-His Met1-His245
Human KIR2DL3-3527H Recombinant Human KIR2DL3 Protein (His22-His245), C-His tagged Mammalian cells C-His His22-His245
Homo sapiens (Human) RFL10148HF Recombinant Full Length Human Killer Cell Immunoglobulin-Like Receptor 2Dl3(Kir2Dl3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-341)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KIR2DL3 Related Articles
  • KIR2DL3 Related Research Area

KIR2DL3 involved in several pathways and played different roles in them. We selected most pathways KIR2DL3 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationHSPA4;HSPA1B;PDIA3;HLA-B;HLA-DRA;KIR2DS5;KIR2DS3;KIR2DS4;KLRC3
Natural killer cell mediated cytotoxicityTNF;SYK;FAS;NFATC2;PIK3CB;HLA-A;KIR3DL1;IFNAR1;NCR1
Graft-versus-host diseaseHLA-C;Fasl;HLA-DRB1;HLA-E;IL1A;CD80;Il2;HLA-A;KIR3DL1

KIR2DL3 has several biochemical functions, for example, antigen binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL3 itself. We selected most functions KIR2DL3 had, and list some proteins which have the same functions with KIR2DL3. You can find most of the proteins on our site.

Function Related Protein
antigen bindingIGKC;TSPAN4;IGJ;MHC1UKA;LILRA2;FCN2;PPP2R1A;KIR2DL3;CD40
protein bindingPPP1R13L;PPM1A;SLC8A1;KHDC3;TMEM43;LYSMD1;MASP1;PAWR;AKAP8L
receptor activityABP1;KIR2DL3;CSF3R;AGER;CALCR;SLC20A1;ROBO4;GRIA4A;PAQR9

KIR2DL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL3.

PTPN6; PTPN11; Ptpn6

Guo, H; Xu, BC; et al. A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis-a pilot study. IMMUNOLOGICAL INVESTIGATIONS 43:312-323(2014).
Hilton, HG; Vago, L; et al. Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a More Refined but Less Adaptable NK Cell Receptor Than KIR2DL3. JOURNAL OF IMMUNOLOGY 189:1418-1430(2012).
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