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KIR3DL1

  • Official Full Name

    killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

  • Overview

    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
  • Synonyms

    KIR3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; KIR; killer cell immunoglobulin-like receptor 3DL1; AMB11; CD158e1; CD158e1/2; CD158e2; cl 2; cl 11; nkat3; NKB1; NKB1B; CD158 antigen-like family member E; CD158E; CD158e antigen; CL11; CL2; HLA-BW4-specific inhibitory NK cell receptor; killer cell immunoglobulin like receptor; Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1; Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1; KIR antigen 3DL1; KIR G1; KIR3DS1; Kirl1; Kirl2; Krl1; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; Natural killer associated transcript 3; Natural killer cell inhibitory receptor; NK receptor; NK-associated transcript 10; NK-associated transcript 3; NK-associated transcript 3delIg1; NKAT10; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL 2/CL 11; NKAT-3; NK-receptor; OTTHUMP00000068687; OTTHUMP00000068688; OTTHUMP00000081758; killer Ig receptor; p70 NK receptor CL-2/CL-11; p70 ki; KIR3DL1/S1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KIR3DL1-349H Recombinant Human Killer Cell Immunoglobulin-like Receptor, Three Domains, Long Cytoplasmic Tail, 1, His-tagged E.coli His
Human KIR3DL1-4417H Recombinant Human Killer Cell Immunoglobulin-like Receptor, Three Domains, Long Cytoplasmic Tail, 1 Human N/A
Human KIR3DL1-935HCL Recombinant Human KIR3DL1 cell lysate N/A
Human KIR3DL1-084H Recombinant Human KIR3DL1 Protein, C-His-tagged E.coli C-His
Human KIR3DL1-4343H Recombinant Human KIR3DL1 Protein (Met1-His340), C-His tagged Mammalian cells C-His Met1-His340
Rat KIR3DL1-3261R Recombinant Rat KIR3DL1 Protein Mammalian Cell His
Rat KIR3DL1-2917R Recombinant Rat KIR3DL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KIR3DL1-2917R-B Recombinant Rat KIR3DL1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL12281HF Recombinant Full Length Human Killer Cell Immunoglobulin-Like Receptor 3Dl1(Kir3Dl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-444)
Mus musculus (Mouse) RFL13541MF Recombinant Full Length Mouse Killer Cell Immunoglobulin-Like Receptor 3Dl1(Kir3Dl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-432)
Rattus norvegicus (Rat) RFL36386RF Recombinant Full Length Rat Killer Cell Immunoglobulin-Like Receptor 3Dl1(Kir3Dl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-422)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KIR3DL1 Related Articles
  • KIR3DL1 Related Research Area

KIR3DL1 involved in several pathways and played different roles in them. We selected most pathways KIR3DL1 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR3DL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationCTSS;HSPA1B;PDIA3;KIR3DL1;HSPA2;HLA-DQA1;IFNG;RFX5;B2M
Natural killer cell mediated cytotoxicityMICA;PIK3R3;PIK3CD;NCR1;IFNB1;KLRC1;IFNA10;IFNA2;PTPN11
Graft-versus-host diseaseHLA-E;HLA-DOB;H2-Q10;IL1A;HLA-DPB1;HLA-DRB4;Fasl;HLA-DRB3;IL6

KIR3DL1 has several biochemical functions, for example, HLA-B specific inhibitory MHC class I receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR3DL1 itself. We selected most functions KIR3DL1 had, and list some proteins which have the same functions with KIR3DL1. You can find most of the proteins on our site.

Function Related Protein
HLA-B specific inhibitory MHC class I receptor activityKIR3DL1;LILRB1

KIR3DL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR3DL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR3DL1.

RPS6KB1; env

Gooneratne, SL; Richard, J; et al. Slaying the Trojan Horse: Natural Killer Cells Exhibit Robust Anti-HIV-1 Antibody-Dependent Activation and Cytolysis against Allogeneic T Cells. JOURNAL OF VIROLOGY 89:97-109(2015).
de Rham, C; Hadaya, K; et al. Expression of killer cell immunoglobulin-like receptors (KIRs) by natural killer cells during acute CMV infection after kidney transplantation. TRANSPLANT IMMUNOLOGY 31:157-164(2014).
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