KLF5 Protein, Kruppel-like factor 5 (intestinal)


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Official Full Name Kruppel-like factor 5 (intestinal)
Background This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Synonyms KLF5; Kruppel-like factor 5 (intestinal); CKLF; IKLF; BTEB2; Krueppel-like factor 5; BTE-binding protein 2; GC box binding protein 2; colon kruppel-like factor; colon krueppel-like factor; transcription factor BTEB2; intestinal-enriched kruppel-like factor; intestinal-enriched krueppel-like factor; basic transcription element binding protein 2;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KLF5-133H Recombinant Human KLF5 protein, T7/His-tagged E.coli T7/His
    Human KLF5-134H Recombinant Human KLF5 protein, His-tagged E.coli His
    Mouse KLF5-8685M Recombinant Mouse KLF5 Protein Mammalian Cell His

    KLF5 involved in several pathways and played different roles in them. We selected most pathways KLF5 participated on our site, such as Adipogenesis, Mus musculus biological processes, PluriNetWork, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipogenesis GTF3AA; GDF10; EGR2B; STIL; PLIN2; DDIT3; BSCL2; HMGA1-RS1; MBNL1; CEBPA
    Mus musculus biological processes MED11; SYCE2; POT1A; SYNE2; SYCP1; KLF5; SUN2
    PluriNetWork RCOR2; ZMYM2; ZSCAN10; ZFP143; XPO4; IPO7; SALL3; ZFP57; KLF5; SMARCC1
    Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes KLF5; MED11

    KLF5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF5 itself. We selected most functions KLF5 had, and list some proteins which have the same functions with KLF5. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SP1; KLF13; HSF1; EHF; HINFP; ATOH1; MYOG; TFE3; ISL1; SKIL
    metal ion binding HECTD1; PFKMA; GNA15; PRDM14; MYLK; ZNF114; ZNF597; PDE7B; TDO2A; ZNF438
    nucleic acid binding SALL3; HIVEP2; ENOX1; BCL6A; RBPMS2; RNASE11; PNMA3; PABPC1L; SRSF7A; NARS
    protein binding RNF139; ILK; PPP1R2P9; OGG1; RCOR1; AGBL1; TNS1; EPN2; CCT3; GEMIN8
    sequence-specific DNA binding HMX4; NKX1-2; POU2F3; TFAP2A; FOXG1B; GLI2; NR5A1B; HOXB3A; POU4F2; PPARA
    transcription factor activity, sequence-specific DNA binding NKX6-2; POU4F1; ZNF493; RUNX1; ZNF454; ZNF711; TFDP1; BATF3; BATF; SREBF1
    transcription factor binding RPS3; PAX2; ERCC3; CTNNB1; EP300; RBFOX2; TFDP1A; MYC; PPP1R13L; HDAC11
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Ar; GLI2; ONECUT1; PGR; MYBL1; ATOH1; SMAD4; MEOX1; PPARA; AKNA

    KLF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF5.

    Lyn; Pou5f1; Tfcp2l1; Nanog; Sall4

    Gyorffy, B; Schafer, R; et al. Biomarkers Downstream of RAS: A Search for Robust Transcriptional Targets. CURRENT CANCER DRUG TARGETS 10:858-868(2010).
    Rageul, J; Mottier, S; et al. KLF4-dependent, PPAR gamma-induced expression of GPA33 in colon cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 125:2802-2809(2009).

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