• Official Full Name
  • kallikrein B, plasma (Fletcher factor) 1
  • Background
  • Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KLKB1; kallikrein B, plasma (Fletcher factor) 1; PPK; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain;
Source (Host):YeastSpecies:Human
Product nameRecombinant Human KLKB1 Protein (20-390 aa), His-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat KLKB1 Protein (391-638 aa), His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLKB1 Protein, GST-tagged
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat KLKB1 Protein, His-tagged
Source (Host):NS0Species:Human
Product nameRecombinant Human Kallikrein B, Plasma (Fletcher factor) 1, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLKB1 protein, His & T7-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLKB1 protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Klkb1 Protein, His-tagged
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Klkb1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KLKB1 Protein
Source (Host):Human UrineSpecies:Human
Product nameNative Human Kallikrein
Source (Host):Species:Human
Product nameNative Human KLKB1
Source (Host):Porcine (pig) PancreasSpecies:Pig
Product nameNative Porcine Kallikrein
Source (Host):Species:Human
Product nameRecombinant Human KLKB1 293 Cell Lysate

Involved Pathway

KLKB1 involved in several pathways and played different roles in them. We selected most pathways KLKB1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
F7; C4BPB; F2; C8A; BDKRB1; SERPIND1; C8G; C3; C9; MASP2

Protein Function

KLKB1 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLKB1 itself. We selected most functions KLKB1 had, and list some proteins which have the same functions with KLKB1. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein RPL13; APOA4; ARHGEF1; Itga10&Itgb1; HAT1; CALM2; EXOSC2; PTPRG; ORMDL3; SRGN
Function serine-type endopeptidase activity
Related Protein PCSK2; PRSS48; PLAUB; PCSK4; KLK1B24; TMPRSS4A; TPSB2; PRSS42; PRSS50; PCSK6