Recombinant Human KLKB1 protein, His-tagged
Cat.No. : | KLKB1-485H |
Product Overview : | Recombinant Human KLKB1(Gly20-Ala638) fused with His tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH8.0 |
Protein length : | Gly20-Ala638 |
AA Sequence : | GCLTQLYENAFFRGGDVASMYTPNA QYCQMRCTFHPRCLLFSFLPASSIN DMEKRFGCFLKDSVT GTLPKVHRTGAVSGHSLKQCGHQIS ACHRDIYKGVDMRGVNFNVSKVSSV EECQKRCTNNIRCQF FSYATQTFHKAEYRNNCLLKYSPGG TPTAIKVLSNVESGFSLKPCALSEI GCHMNIFQHLAFSDV DVARVLTPDAFVCRTICTYHPNCLF FTFYTNVWKIESQRNVCLLKTSESG TPSSSTPQENTISGY SLLTCKRTLPEPCHSKIYPGVDFGG EELNVTFVKGVNVCQETCTKMIRCQ FFTYSLLPEDCKEEK CKCFLRLSMDGSPTRIAYGTQGSSG YSLRLCNTGDNSVCTTKTSTRIVGG TNSSWGEWPWQVSLQ VKLTAQRHLCGGSLIGHQWVLTAAH CFDGLPLQDVWRIYSGILNLSDITK DTPFSQIKEIIIHQN YKVSEGNHDIALIKLQAPLNYTEFQ KPICLPSKGDTSTIYTNCWVTGWGF SKEKGEIQNILQKVN IPLVTNEECQKRYQDYKITQRMVCA GYKEGGKDACKGDSGGPLVCKHNGM WRLVGITSWGEGCAR REQPGVYTKVAEYMDWILEKTQSSD GKAQMQSPAVDHHHHHH |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Store at < -20 centigrade, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Shipping : | The product is shipped on dry ice/ice packs. |
Gene Name : | KLKB1 kallikrein B, plasma (Fletcher factor) 1 [ Homo sapiens ] |
Official Symbol : | KLKB1 |
Synonyms : | KLKB1; kallikrein B, plasma (Fletcher factor) 1; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain; PPK; |
Gene ID : | 3818 |
mRNA Refseq : | NM_000892 |
Protein Refseq : | NP_000883 |
MIM : | 229000 |
UniProt ID : | P03952 |
Chromosome Location : | 4q35 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; |
Function : | peptidase activity; protein binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
Klkb1-1277M | Recombinant Mouse Klkb1 Protein, MYC/DDK-tagged | +Inquiry |
KLKB1-3238H | Recombinant Human KLKB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Klkb1-4883M | Recombinant Mouse Klkb1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLKB1-605R | Recombinant Rat KLKB1 Protein (391-638 aa), His-tagged | +Inquiry |
KLKB1-4925H | Recombinant Human KLKB1 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
KLKB1-210H | Active Native Human Kallikrein | +Inquiry |
KLKB1-211S | Active Native Porcine Kallikrein | +Inquiry |
KLKB1-27924TH | Native Human KLKB1 | +Inquiry |
◆ Lysates | ||
KLKB1-4899HCL | Recombinant Human KLKB1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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