| Description : |
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71.37 kDa |
| AA Sequence : |
MILFKQATYFISLFATVSCGCLTQL YENAFFRGGDVASMYTPNAQYCQMR CTFHPRCLLFSFLPASSINDMEKRF GCFLKDSVTGTLPKVHRTGAVSGHS LKQCGHQISACHRDIYKGVDMRGVN FNVSKVSSVEECQKRCTNNIRCQFF SYATQTFHKAEYRNNCLLKYSPGGT PTAIKVLSNVESGFSLKPCALSEIG CHMNIFQHLAFSDVDVARVLTPDAF VCRTICTYHPNCLFFTFYTNVWKIE SQRNVCLLKTSESGTPSSSTPQENT ISGYSLLTCKRTLPEPCHSKIYPGV DFGGEELNVTFVKGVNVCQETCTKM IRCQFFTYSLLPEDCKEEKCKCFLR LSMDGSPTRIAYGTQGSSGYSLRLC NTGDNSVCTTKTSTRIVGGTNSSWG EWPWQVSLQVKLTAQRHLCGGSLIG HQWVLTAAHCFDGLPLQDVWRIYSG ILNLSDITKDTPFSQIKEIIIHQNY KVSEGNHDIALIKLQAPLNYTEFQK PICLPSKGDTSTIYTNCWVTGWGFS KEKGEIQNILQKVNIPLVTNEECQK RYQDYKITQRMVCAGYKEGGKDACK GDSGGPLVCKHNGMWRLVGITSWGE GCARREQPGVYTKVAEYMDWILEKT QSSDGKAQMQSPATRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
