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Recombinant Human KLKB1 Protein, GST-tagged

Cat.No. : KLKB1-4925H
Product Overview : Human KLKB1 full-length ORF (BAG36176.1, 1 a.a. - 638 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 96.58 kDa
AA Sequence : MILFKQATYFISLFATVSCGCLTQL YENAFFRGGDVASMYTPNAQYCQMR CTFHPRCLLFSFLPASSINDMEKRF GCFLKDSVTGTLPKVHRTGAVSGHS LKQCGHQISACHRDIYKGVDMRGVN FNVSKVSSVEECQKRCTNNIRCQFF SYATQTFHKAEYRNNCLLKYSPGGT PTAIKVLSNVESGFSLKPCALSEIG CHMNIFQHLAFSDVDVARVLTPDAF VCRTICTYHPNCLFFTFYTNVWKIE SQRNVCLLKTSESGTPSSSTPQENT ISGYSLLTCKRTLPEPCHSKIYPGV DFGGEELNVTFVKGVNVCQETCTKM IRCQFFTYSLLPEDCKEEKCKCFLR LSMDGSPTRIAYGTQGSSGYSLRLC NTGDNSVCTTKTSTRIVGGTNSSWG EWPWQVSLQVKLTAQRHLCGGSLIG HQWVLTAAHCFDGLPLQDVWRIYSG ILNLSDITKDTPFSQIKEIIIHQNY KVSEGNHDIALIKLQAPLNYTEFQK PICLPSKGDTSTIYTNCWVTGWGFS KEKGEIQNILQKVNIPLVTNEECQK RYQDYKITQRMVCAGYKEGGKDACK GDSGGPLVCKHNGMWRLVGITSWGE GCARREQPGVYTKVAEYMDWILEKT QSSDGKAQMQSPA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : KLKB1 kallikrein B, plasma (Fletcher factor) 1 [ Homo sapiens ]
Official Symbol : KLKB1
Synonyms : KLKB1; kallikrein B, plasma (Fletcher factor) 1; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain; PPK;
Gene ID : 3818
mRNA Refseq : NM_000892
Protein Refseq : NP_000883
MIM : 229000
UniProt ID : P03952

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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