L2HGDH Protein, L-2-hydroxyglutarate dehydrogenase

L2HGDH

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L2HGDH

Official Full Name L-2-hydroxyglutarate dehydrogenase
Background This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.
Synonyms L2HGDH; L-2-hydroxyglutarate dehydrogenase; C14orf160, chromosome 14 open reading frame 160; L-2-hydroxyglutarate dehydrogenase, mitochondrial; 2 hydroxyglutarate dehydrogenase; FLJ12618; mitochondrial; C14orf160; Duranin; L2HDH_HUMAN; OTTHUMP00000178967; OTTHUMP00000178968; OTTHUMP00000244606; alpha-ketoglutarate reductase; 2-hydroxyglutarate dehydrogenase; alpha-hydroxyglutarate oxidoreductase; L-alpha-hydroxyglutarate dehydrogenase
    • Species :
    • Bovine
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human L2HGDH-1120H Recombinant Human L2HGDH Protein (52-463 aa), His-SUMO-tagged E.coli His/SUMO
    Bovine L2HGDH-615B Recombinant Bovine L2HGDH Protein (53-463 aa), His-SUMO-tagged E.coli His/SUMO
    Human L2HGDH-173H Recombinant Human L2HGDH Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human L2HGDH-372HCL Recombinant Human L2HGDH lysate HEK293 N/A
    Human L2HGDH-944H Recombinant Human L2HGDH Mammalian Cell His
    Zebrafish L2HGDH-7342Z Recombinant Zebrafish L2HGDH Mammalian Cell His

    L2HGDH involved in several pathways and played different roles in them. We selected most pathways L2HGDH participated on our site, such as Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with L2HGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Butanoate metabolism Acsm2a; ALDH5A1; ACAT2; OXCT1; OXCT1A; ECHS1; ACSM2; ACSM5; GAD1; ACSM3

    L2HGDH has several biochemical functions, for example, 2-hydroxyglutarate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by L2HGDH itself. We selected most functions L2HGDH had, and list some proteins which have the same functions with L2HGDH. You can find most of the proteins on our site.

    Function Related Protein
    2-hydroxyglutarate dehydrogenase activity L2HGDH

    L2HGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L2HGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of L2HGDH.

    ATL3

    Shim, EH; Livi, CB; et al. L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. CANCER DISCOVERY 4:1290-1298(2014).
    Balaji, P; Viswanathan, V; et al. An interesting case of metabolic dystonia: L-2 hydroxyglutaric aciduria. ANNALS OF INDIAN ACADEMY OF NEUROLOGY 17:97-99(2014).

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