|Official Full Name||L-2-hydroxyglutarate dehydrogenase|
|Background||This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.|
|Synonyms||L2HGDH; L-2-hydroxyglutarate dehydrogenase; C14orf160, chromosome 14 open reading frame 160; L-2-hydroxyglutarate dehydrogenase, mitochondrial; 2 hydroxyglutarate dehydrogenase; FLJ12618; mitochondrial; C14orf160; Duranin; L2HDH_HUMAN; OTTHUMP00000178967; OTTHUMP00000178968; OTTHUMP00000244606; alpha-ketoglutarate reductase; 2-hydroxyglutarate dehydrogenase; alpha-hydroxyglutarate oxidoreductase; L-alpha-hydroxyglutarate dehydrogenase|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
L2HGDH involved in several pathways and played different roles in them. We selected most pathways L2HGDH participated on our site, such as Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with L2HGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Butanoate metabolism||Acsm2a; ALDH5A1; ACAT2; OXCT1; OXCT1A; ECHS1; ACSM2; ACSM5; GAD1; ACSM3|
L2HGDH has several biochemical functions, for example, 2-hydroxyglutarate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by L2HGDH itself. We selected most functions L2HGDH had, and list some proteins which have the same functions with L2HGDH. You can find most of the proteins on our site.
|2-hydroxyglutarate dehydrogenase activity||L2HGDH|
L2HGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L2HGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of L2HGDH.