LIN28B Protein, lin-28 homolog B


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Official Full Name lin-28 homolog B
Background LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. The let-7 miRNAs have been implicated in repression of oncogenes such as ras, myc, and Hmga2. It has
Synonyms LIN28B; lin-28 homolog B (C. elegans); protein lin-28 homolog B; CSDD2; FLJ16517; lin-28B; Lin-28.2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIN28B-1034H Recombinant Human LIN28B Mammalian Cell His
    Human LIN28B-4733HCL Recombinant Human LIN28B 293 Cell Lysate HEK293 N/A
    Human LIN28B-7186H Recombinant Human Lin-28 Homolog B (C. elegans), His-tagged E.coli His
    Mouse LIN28B-9113M Recombinant Mouse LIN28B Protein Mammalian Cell His
    Chicken LIN28B-3276C Recombinant Chicken LIN28B Mammalian Cell His
    Zebrafish LIN28B-8475Z Recombinant Zebrafish LIN28B Mammalian Cell His

    LIN28B involved in several pathways and played different roles in them. We selected most pathways LIN28B participated on our site, such as Cardiac Progenitor Differentiation, Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cardiac Progenitor Differentiation NOG; ROR2; LIN28A; SOX1; T; IRX4; SIRPA; TBX5; BMP1; NKX2
    Validated targets of C-MYC transcriptional activation IREB2; LIN28B; SERPINI1; PDCD10; CDCA7; MINA; NDUFAF2; MTDH; PRDX3; PEG10

    LIN28B has several biochemical functions, for example, DNA binding, RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28B itself. We selected most functions LIN28B had, and list some proteins which have the same functions with LIN28B. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HOXB1B; TFDP2; VEZF1; BLZF1; MBD1; ZFP641; ZNF800; SMC1B; NPAS1; TAF11
    poly(A) RNA binding HARS2; PPIL4; TRNAU1AP; CASC3; TFB1M; MRPS11; CHERP; RBM12B; KTN1; SAFB
    protein binding CNOT8; LMF2; FAM129A; RRAGD; PLK3; RAB34; KCNA1; PFTK1; DYRK4; NUP62L
    zinc ion binding CPD; WT1; ZCCHC12; RNF138; SUPT4H1; PDXK; ZFAND5A; TRIM67; ADAMTS15; ESRRA

    LIN28B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28B.

    pre-let-7a; YBX1; pre-mir-107; ZCCHC11; USP36; ssrna_cg

    Williams, KA; Labidi-Galy, SI; et al. Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. GYNECOLOGIC ONCOLOGY 132:542-550(2014).
    Helland, A; Anglesio, MS; et al. Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers. PLOS ONE 6:-(2011).
    Guo, YQ; Chen, YX; et al. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. GENE 384:51-61(2006).

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