LONP1 Protein, lon peptidase 1, mitochondrial


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Official Full Name lon peptidase 1, mitochondrial
Background This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.
Synonyms LONP1; lon peptidase 1, mitochondrial; protease, serine, 15 , PRSS15; lon protease homolog, mitochondrial; hLON; LonHS; PIM1; Serine protease 15; hLON ATP dependent protease; Lon protease like protein; LONP; MGC1498; PRSS15; LON; LON protease; Mitochondrial ATP dependent protease Lon; Mitochondrial lon peptidase 1; Protease serine 15; protease, serine, 15; Lon protease-like protein; hLON ATP-dependent protease; mitochondrial lon protease-like protein; mitochondrial ATP-dependent protease Lon
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LONP1-1423HCL Recombinant Human LONP1 cell lysate N/A
    Human LONP1-4737H Recombinant Human LONP1 Protein, GST-tagged Wheat Germ GST
    Mouse LONP1-9178M Recombinant Mouse LONP1 Protein Mammalian Cell His
    Rat LONP1-3431R Recombinant Rat LONP1 Protein Mammalian Cell His

    LONP1 involved in several pathways and played different roles in them. We selected most pathways LONP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LONP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    LONP1 has several biochemical functions, for example, ADP binding, ATP binding, ATP-dependent peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LONP1 itself. We selected most functions LONP1 had, and list some proteins which have the same functions with LONP1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PAK2A; CCT6A; MYO1A; BTK; EIF4A3; C22orf28; KIF11; EK1; PRKCBA; PCCB
    ATP-dependent peptidase activity LONRF2; YME1L1; SPG7; AFG3L2; LONRF1L; LONP1; CRBN; LONRF3
    DNA polymerase binding SMARCA4; LONP1; CDK2AP1; PCNA; ACD; RAD51; HMGB1; FANCD2; FANCI
    G-quadruplex DNA binding LONP1; WRN; DHX36; BLM
    mitochondrial heavy strand promoter anti-sense binding LONP1
    NOT mitochondrial heavy strand promoter sense binding LONP1
    mitochondrial light strand promoter anti-sense binding LONP1
    NOT mitochondrial light strand promoter sense binding LONP1
    protein binding FOXK1; SERPINA1A; UGGT2; NKAP; RPL11; IFNA4; YBX1; HSFX1; NOXO1; ROBO1
    sequence-specific DNA binding TLX3B; FOXC1A; AHR; HOXA2B; FOXF2; NKX2-1; IRX1B; HOXA11B; NKX2.7; MXTX2
    serine-type endopeptidase activity CTRB1; TMPRSS11G; PRSS2; TMPRSS3; F2; PCSK5; PRSS44; PCSK6; KLK1B11; C1RA
    single-stranded DNA binding HSPD1; NME2; RAD51D; HNRNPDL; ALYREF; PEO1; TDP2; HMGB1; XRCC3; CDC45
    single-stranded RNA binding AGO1; DDX58; SNRPC; A1CF; CBX7; DHX58; CBX4; LSM14A; TLR7; POLR2G

    LONP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LONP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LONP1.

    CSN2; USP2; TSC22D1; MAP3K3; ATG101; IFIT3; A2M; CYP2C8; IFIT5; CDC37; fumA; LOXL4; ECSIT; RNF32

    Strauss, KA; Jinks, RN; et al. CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA(+) Lon Protease. AMERICAN JOURNAL OF HUMAN GENETICS 96:121-135(2015).
    Goo, HG; Rhim, H; et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. EXPERIMENTAL CELL RESEARCH 328:456-465(2014).

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