lpar1
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  • Official Full Name
  • lysophosphatidic acid receptor 1
  • Background
  • The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG;receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell;signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth;muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two;transcript variants encoding the same protein have been identified for this gene.
  • Synonyms
  • LPAR1; lysophosphatidic acid receptor 1; EDG2, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2; edg 2; Gpcr26; GPR26; LPA1; Mrec1.3; rec.1.3; vzg 1; 5031439C20; AI326300; Endothelial Cell Differentiation Gene-2; Endothelial differentiation gene 2; Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2; G10 protein homolog; GPCR 26; Gpcr91; Kdt2; LPA 1; LPA receptor 1; LPA receptor EDG2; LPA-1; LPAR1_HUMAN; Lysophosphatidic acid receptor Edg-2; Lysophosphatidic acid receptor EDG2; MGC105279; MGC29102; REC1.3; Ventricular zone gene 1; vzg-1; VZG1; OTTHUMP00000021903; OTTHUMP00000021904; OTTHUMP00000021905; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; EDG2; edg-2
Cat.#:LPAR1-490HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LPAR1 protein, GST-tagged
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Cat.#:LPAR1-616HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LPAR1, GST-tagged
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Cat.#:LPAR1-9189MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LPAR1 Protein
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Cat.#:LPAR1-3434RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LPAR1 Protein
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Cat.#:LPAR1-2539RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LPAR1 Protein, His-tagged
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Cat.#:LPAR1-3831CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LPAR1
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Cat.#:LPAR1-1245ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LPAR1
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Cat.#:LPAR1-4675HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LPAR1 293 Cell Lysate
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Involved Pathway

LPAR1 involved in several pathways and played different roles in them. We selected most pathways LPAR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
CCL19A.2; KISS1; CCK; APLN; OPN1LW1; DRD2; PNOCB; LPAR2B; HCRT; SSTR1
G alpha (i) signalling events
ADRA2A; ANXA1; TAS2R3; ADORA3; OXGR1A.3; GPR17; SSTR2; RGS11; GPR55A; RLN3
G alpha (q) signalling events
MGLL; LPAR5A; EDN2; TRPC3; DGKB; ANXA1C; ADRA1D; GPR65; TRIO; DGKG
GPCR downstream signaling
OR4D2; GAL; RGS6; GPR68; CHRM1; UTS2; PTHRP2; EDNRAB; KALRNB; RHOAE
GPCR ligand binding
EDN3; EMR2; OPN4.1; CXCR6; SSTR2; TAC2; PMCH; ZFPM2B; PROKR1A; FPR-RS4
Gap junction
TJP1; HTR2A; GNA11A; GRB2B; PRKCB; PDGFD; SOS1; PLCB4; PDGFA; TUBB
Gastrin-CREB signalling pathway via PKC and MAPK
TAE1; NPFFR2; QRFP; ANXA1; ABHD12; LTB4R; EDN3; KISS1; RGS21; FPR-RS4
LPA receptor mediated events
LPAR1; GNA13

Protein Function

LPAR1 has several biochemical functions, for example, G-protein alpha-subunit binding, G-protein coupled receptor activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR1 itself. We selected most functions LPAR1 had, and list some proteins which have the same functions with LPAR1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein alpha-subunit binding
Related Protein PPP5C; LPAR3; OPRM1; IGF1R; DRD1; ARHGEF11; HTR2B; RGS4; RIC8A; HTR2A
Function G-protein coupled receptor activity
Related Protein OPRM1; MTNR1AA; CXCR6; TAS1R2.2; DRD7; OLFR10; NTSR1; GRM2A; FZD1; EMR2
Function PDZ domain binding
Related Protein PTEN; GRID2; GRIK2; CCDC88C; PDZK1; PLEKHA2; LRP2; NSF; BAIAP2; LNX2
Function lysophosphatidic acid binding
Related Protein LPAR1; GAP43; VIL1
Function lysophosphatidic acid receptor activity
Related Protein LPAR1; LPAR6A; LPAR3; LPAR2A; LPAR2; LPAR2B
Function protein binding
Related Protein ECHS1; THOP1; DDIT3; PVR; MLPH; PPIA; CARF; CAMKK1; GAS6; CPEB3

Interacting Protein

LPAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR1.
KRAS

LPAR1 Related Articles

Ryu, JM; Han, HJ; et al. Autotaxin-LPA Axis Regulates hMSC Migration by Adherent Junction Disruption and Cytoskeletal Rearrangement Via LPAR1/3-Dependent PKC/GSK3 beta/beta-Catenin and PKC/Rho GTPase Pathways. STEM CELLS 33:819-832(2015).
Wu, L; Petrigliano, FA; et al. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. OSTEOARTHRITIS AND CARTILAGE 23:308-318(2015).