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LPCAT4

  • Official Full Name

    lysophosphatidylcholine acyltransferase 4

  • Overview

    Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the;conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all;glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 (PubMed 16243729)).
  • Synonyms

    LPCAT4; lysophosphatidylcholine acyltransferase 4; 1 acylglycerol 3 phosphate O acyltransferase 7 (lysophosphatidic acid acyltransferase, eta) , acyltransferase like 3 , AGPAT7, AYTL3; lysophospholipid acyltransferase LPCAT4; FLJ10257; LPAAT eta; LPEAT2; lysophosphatidylethanolamine acyltransferase 2; 1 acyl sn glycerol 3 phosphate acyltransferase eta; 1 AGP acyltransferase 7; 1 AGPAT 7; Acyltransferase like 3; AGPAT7; AYTL3; Lysophosphatidic acid acyltransferase eta; 1-AGPAT 7; acyltransferase-like 3; 1-AGP acyltransferase 7; PLSC domain containing protein; acyl-CoA:lysophosphatidylethanolamine acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); LPAAT-eta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LPCAT4-623H Recombinant Human LPCAT4, His-tagged E.coli His 175-524aa
Human LPCAT4-437H Recombinant Human LPCAT4 Protein, GST-tagged Wheat Germ GST
Human LPCAT4-4670HCL Recombinant Human LPCAT4 293 Cell Lysate HEK293 N/A
Human LPCAT4-3867H Recombinant Human LPCAT4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LPCAT4-935HF Recombinant Full Length Human LPCAT4 Protein, GST-tagged In Vitro Cell Free System GST 524 amino acids
Mouse Lpcat4-3809M Recombinant Mouse Lpcat4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Homo sapiens (Human) RFL1972HF Recombinant Full Length Human Lysophospholipid Acyltransferase Lpcat4(Lpcat4) Protein, His-Tagged E.coli expression system His Full Length (1-524)
Mus musculus (Mouse) RFL5043MF Recombinant Full Length Mouse Lysophospholipid Acyltransferase Lpcat4(Lpcat4) Protein, His-Tagged E.coli expression system His Full Length (1-524)
Xenopus laevis (African clawed frog) RFL4531XF Recombinant Full Length Xenopus Laevis Lysophospholipid Acyltransferase Lpcat4(Lpcat4) Protein, His-Tagged E.coli expression system His Full Length (1-522)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL352XF Recombinant Full Length Xenopus Tropicalis Lysophospholipid Acyltransferase Lpcat4(Lpcat4) Protein, His-Tagged E.coli expression system His Full Length (1-522)
Zebrafish LPCAT4-11603Z Recombinant Zebrafish LPCAT4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LPCAT4 Related Articles

LPCAT4 involved in several pathways and played different roles in them. We selected most pathways LPCAT4 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPCAT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismMBOAT2B;PLD1;LPCAT3;DGKB;GPAT2;LCAT;LYPLA2;LYPLA1;MBOAT1
Ether lipid metabolismPLA2G10;PPAP2B;TMEM86B;PAFAH1B1A;PAFAH1B2;PLA2G4C;PAFAH1B1;LPCAT1;UGT8A
Metabolic pathwaysPHYKPL;PGLS;FASN;SHMT2;TGDS;DCT;PRPS1;GALNS;ST6GALNAC5

LPCAT4 has several biochemical functions, for example, 1-acylglycerophosphocholine O-acyltransferase activity, 1-alkenylglycerophosphoethanolamine O-acyltransferase activity, 1-alkylglycerophosphocholine O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPCAT4 itself. We selected most functions LPCAT4 had, and list some proteins which have the same functions with LPCAT4. You can find most of the proteins on our site.

Function Related Protein
1-acylglycerophosphocholine O-acyltransferase activityLPCAT3;TAZ;LPCAT4;LPCAT1;LPCAT2
1-alkenylglycerophosphoethanolamine O-acyltransferase activity
1-alkylglycerophosphocholine O-acetyltransferase activityLPCAT1;LPCAT4;LPCAT2
lysophospholipid acyltransferase activityMBOAT7;LPCAT4

LPCAT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPCAT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPCAT4.

Zhou, M; Osanai, K; et al. Adenovector-Mediated Gene Transfer of Lysophosphatidylcholine Acyltransferase 1 Attenuates Oleic Acid-Induced Acute Lung Injury in Rats. CRITICAL CARE MEDICINE 42:E716-E724(2014).
Fennell, DA; Myrand, SP; et al. Association between Gene Expression Profiles and Clinical Outcome of Pemetrexed-Based Treatment in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Exploratory Results from a Phase II Study. PLOS ONE 9:-(2014).
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