lpcat4
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  • Official Full Name
  • lysophosphatidylcholine acyltransferase 4
  • Background
  • Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the;conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all;glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 (PubMed 16243729)).
  • Synonyms
  • LPCAT4; lysophosphatidylcholine acyltransferase 4; 1 acylglycerol 3 phosphate O acyltransferase 7 (lysophosphatidic acid acyltransferase, eta) , acyltransferase like 3 , AGPAT7, AYTL3; lysophospholipid acyltransferase LPCAT4; FLJ10257; LPAAT eta; LPEAT2; lysophosphatidylethanolamine acyltransferase 2; 1 acyl sn glycerol 3 phosphate acyltransferase eta; 1 AGP acyltransferase 7; 1 AGPAT 7; Acyltransferase like 3; AGPAT7; AYTL3; Lysophosphatidic acid acyltransferase eta; 1-AGPAT 7; acyltransferase-like 3; 1-AGP acyltransferase 7; PLSC domain containing protein; acyl-CoA:lysophosphatidylethanolamine acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); LPAAT-eta
Cat.#:LPCAT4-437HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LPCAT4 Protein, GST-tagged
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Cat.#:LPCAT4-623HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LPCAT4, His-tagged
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Cat.#:LPCAT4-11603ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LPCAT4
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Cat.#:LPCAT4-4670HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LPCAT4 293 Cell Lysate
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Involved Pathway

LPCAT4 involved in several pathways and played different roles in them. We selected most pathways LPCAT4 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPCAT4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
GPAT2; CEPT1B; CHPT1; GPAM; DGKA; PLD2; CHAT; LYCAT; PLA2G4F; PISD
Ether lipid metabolism
PPAP2D; PLA2G4A; PAFAH1B1B; GAL3ST1A; PLA2G12A; EPT1; PLA2G2D; PLA2G10; PLA2G4C; PLA2G2F
Metabolic pathways
FBP1B; PLA2G4AA; CYP3A41A; GRHPRA; NMRK2; GLUL; ALDH4A1; B3GALNT1; PDHA1; ASAH1B

Protein Function

LPCAT4 has several biochemical functions, for example, 1-acylglycerophosphocholine O-acyltransferase activity, 1-alkenylglycerophosphoethanolamine O-acyltransferase activity, 1-alkylglycerophosphocholine O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPCAT4 itself. We selected most functions LPCAT4 had, and list some proteins which have the same functions with LPCAT4. You can find most of the proteins on our site.
Function
Related Protein
Function 1-acylglycerophosphocholine O-acyltransferase activity
Related Protein LPCAT4; LPCAT3; LPCAT1; TAZ; LPCAT2
Function 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
Related Protein LPCAT4
Function 1-alkylglycerophosphocholine O-acetyltransferase activity
Related Protein LPCAT2; LPCAT1; LPCAT4
Function lysophospholipid acyltransferase activity
Related Protein MBOAT7; LPCAT4

LPCAT4 Related Articles

Zhou, M; Osanai, K; et al. Adenovector-Mediated Gene Transfer of Lysophosphatidylcholine Acyltransferase 1 Attenuates Oleic Acid-Induced Acute Lung Injury in Rats. CRITICAL CARE MEDICINE 42:E716-E724(2014).
Fennell, DA; Myrand, SP; et al. Association between Gene Expression Profiles and Clinical Outcome of Pemetrexed-Based Treatment in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Exploratory Results from a Phase II Study. PLOS ONE 9:-(2014).