lrp8
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  • Official Full Name
  • low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
  • Background
  • This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are;cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific;ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during;development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein;apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced;transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • LRP8; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8; APOER2; ApoE receptor 2; MCI1; LRP-8; HSZ75190
Cat.#:LRP8-4688HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LRP8 Protein, GST-tagged
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Cat.#:LRP8-64HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ApoE R2, CF
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Cat.#:LRP8-7868HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LRP8 protein, His & GST-tagged
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Cat.#:LRP8-6741CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LRP8
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Cat.#:LRP8-4653HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LRP8 293 Cell Lysate
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Involved Pathway

LRP8 involved in several pathways and played different roles in them. We selected most pathways LRP8 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by PRL
RABGGTB; LRP8; PTP4A1; PTP4A3; ATF5; PTP4A2; RABGGTA

Protein Function

LRP8 has several biochemical functions, for example, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP8 itself. We selected most functions LRP8 had, and list some proteins which have the same functions with LRP8. You can find most of the proteins on our site.
Function
Related Protein
Function protein tyrosine phosphatase activity
Related Protein PTPRNA; PTPRJ; DUSP19B; PTP4A2A; PTPN2A; PALD1B; DUSP3; PTPRG; MTMR3; KIAA1274
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein EPM2A; DUSP19B; DUSP1; DUSP21; EYA3; DUSP14; CDC14A; DUSP10; PTPMT1; DUSP26

Interacting Protein

LRP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP8.
APOE; SS18; TYK2; USP11; Pten; ALB; RAD51; ANGEL2; CRTC3; GHDC; C19orf47; PRCC; DOCK6; ARHGAP39; PRKRIP1; CAMSAP3; PPP1R9A