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LRPPRC

  • Official Full Name

    leucine-rich pentatricopeptide repeat containing

  • Overview

    This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]
  • Synonyms

    LRPPRC; leucine-rich pentatricopeptide repeat containing; LSFC; GP130; LRP130; CLONE-23970; leucine-rich PPR motif-containing protein, mitochondrial; LRP 130; 130 kDa leucine-rich protein; leucine-rich PPR-motif containing; mitochondrial leucine-rich PPR motif-containing protein;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRPPRC-4652HCL Recombinant Human LRPPRC 293 Cell Lysate HEK293 N/A
Human LRPPRC-1879HFL Recombinant Full Length Human LRPPRC Protein, C-Flag-tagged Mammalian cells Flag
Human LRPPRC-1319H Recombinant Human LRPPRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LRPPRC-804H Recombinant Human LRPPRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LRPPRC-1319H-B Recombinant Human LRPPRC Protein Pre-coupled Magnetic Beads HEK293
Human LRPPRC-301112H Recombinant Human LRPPRC protein, GST-tagged E.coli GST Leu1014-Ser1394
Mouse LRPPRC-9242M Recombinant Mouse LRPPRC Protein Mammalian Cell His
Mouse Lrpprc-3821M Recombinant Mouse Lrpprc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse LRPPRC-5168M-B Recombinant Mouse LRPPRC Protein Pre-coupled Magnetic Beads HEK293
Mouse LRPPRC-5168M Recombinant Mouse LRPPRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LRPPRC-3457R Recombinant Rat LRPPRC Protein Mammalian Cell His
Rat LRPPRC-3113R Recombinant Rat LRPPRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LRPPRC-3113R-B Recombinant Rat LRPPRC Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LRPPRC-7248Z Recombinant Zebrafish LRPPRC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LRPPRC Related Articles

LRPPRC involved in several pathways and played different roles in them. We selected most pathways LRPPRC participated on our site, such as Gene Expression, Generic Transcription Pathway, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionRARAA;ZFP1;ZNF264;ZNF599;SLBP;MAEL;ZNF398;ZCRB1;ZNF213
Generic Transcription PathwayZNF433;ZNF461;MED8;CCNT2B;ZNF692;NR5A1;ZNF443;ZNF563;ZNF331
MetabolismMMS19;NUDT4A;Gpc2;AQP1A.1;MTF1;ELA2L;KCNJ11;B3GNT3;SLC27A5
Respiratory electron transportTACO1;C2orf56;COX11;TIMMDC1;COX14;ETFA;COX18;NDUFAF4;NDUFAF2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.SLC25A14;NDUFAF2;COX11;COX16;ETFB;TIMMDC1;TACO1;ETFA;COX18
TNF-alpha/NF-kB Signaling PathwayG3BP2;SMARCC2;MCC;RNF25;TRPC4AP;PAPOLA;PDCD2;DPF2;TANK
TP53 Regulates Metabolic GenesFAM36A;COX14;SCO1;SURF1;LRPPRC;TACO1;COX18;PRDX2;SESN3
The citric acid (TCA) cycle and respiratory electron transportPDK3;TACO1;ATP5S;COX16;MPC1;BRP44;COX18;TIMMDC1;ETFB

LRPPRC has several biochemical functions, for example, RNA binding, NOT actin filament binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPPRC itself. We selected most functions LRPPRC had, and list some proteins which have the same functions with LRPPRC. You can find most of the proteins on our site.

Function Related Protein
RNA bindingRPLP0;EIF2S1A;DHX34;NR0B1;KHDC1;BARHL1;PCBP3;RPL8;RBM8A
NOT actin filament bindingMAP1S;LRPPRC;UXT
beta-tubulin bindingARL8A;SLC6A2;PEX14;PROL1;GABARAPL1;LRPPRC;GABARAPL2;MAP1S;SNCA
microtubule bindingTXNDC3;MTUS2;MAP4;KIF20B;CCDC88A;KIFC1;WDR43;MTAP7D3;BIRC5
poly(A) RNA bindingDDX46;PLEC;MEX3C;SR140;RBM19;FAM98B;RBM7;APOBEC3C;ANXA2
protein bindingKNDC1;SLC48A1;HEATR5B;EIF3G;RPS6KC1;ZMAT2;FEN1;COX6B2;ERLIN2
single-stranded DNA bindingRAD51AP1;TDP2;RAD51C;ERCC4;HNRNPA1;WBP11;OBFC2B;RAD23A;HNRNPK
ubiquitin protein ligase bindingTRIB3;BAG4;HM13;USP2;CDC34;SCAMP3;RFFL;UBE2NB;SMAD5

LRPPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPPRC.

MYC; EIF4E; SLIRP; PPARGC1A; vpu; 7242199; Ppargc1a

Baggio, F; Bratic, A; et al. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. NUCLEIC ACIDS RESEARCH 42:13920-13938(2014).
Zhou, JY; Zhang, FH; et al. Downregulation of LRPPRC Induces Apoptosis in Prostate Cancer Cells Through the Mitochondria-Mediated Pathway. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 29:345-350(2014).
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