LRPPRC

  • Official Full Name

    leucine-rich pentatricopeptide repeat containing

  • Overview

    This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

  • Synonyms

    LRPPRC;leucine-rich pentatricopeptide repeat containing;LSFC;GP130;LRP130;CLONE-23970;leucine-rich PPR motif-containing protein, mitochondrial;LRP 130;130 kDa leucine-rich protein;leucine-rich PPR-motif containing;mitochondrial leucine-rich PPR motif-containing protein

Recombinant Proteins

  • Rat
  • Zebrafish
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • GST
  • DDK
  • Myc

    Involved Pathway

    LRPPRC involved in several pathways and played different roles in them. We selected most pathways LRPPRC participated on our site, such as Gene Expression,Generic Transcription Pathway,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression JARID2,ZNF227,CDK9,ZNF726,ADAT3,COX11,NR2E3,ELAVL1,ZFP36L1A,ZNF556
    TNF-alpha/NF-kB Signaling Pathway PFDN2,KPNA6,PEG3,COMMD1,TRAIP,TIFA,NKIRAS2,TXLNA,ZFAND5,SMARCB1
    Generic Transcription Pathway ZNF839,NR2E3,ESRRG,ZNF75D,ZNF500,TRIM28,NR4A2B,HIPK1,ZNF443,ZNF468
    TP53 Regulates Metabolic Genes COX14,FAM36A,COX18,COX16,SURF1,PRDX2,TACO1,SCO1,SESN3
    The citric acid (TCA) cycle and respiratory electron transport SCO1,COX18,C20orf7,ATP5L,NDUFAF5,COX16,SURF1,PDPR,PDK2,ADHFE1
    Respiratory electron transport C2orf56,NDUFAF4,ETFDH,NDUFAF2,NDUFAF3,TACO1,SCO1,NDUFAF7,NDUFA11,NDUFAF5
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. TACO1,C20orf7,COX18,ETFA,NDUFAF7,NDUFAF5,ATP5S,ETFB,UCP2,SLC25A14
    Metabolism BCKDK,ACMSD,MED31,PCBD1,PPP1R2,KCNB1,ST3GAL3A,MTF1,AWAT1,MED8

    Protein Function

    LRPPRC has several biochemical functions, for example, RNA binding,NOT actin filament binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPPRC itself. We selected most functions LRPPRC had, and list some proteins which have the same functions with LRPPRC. You can find most of the proteins on our site.

    Function Related Protein
    beta-tubulin binding HTT,ARL8A,AKAP1,SERPINB1A,PDCD5,PROL1,SNCA,B4GALT1,GABARAP,FGF13
    poly(A) RNA binding HNRNPA0,MRPL32,SNRPA1,PPRC1,CSTF2T,REXO4,HNRNPDL,BRIX1,SLC25A5,RBM4
    ubiquitin protein ligase binding ASB4,PER1,BLZF1,TRP53,MDM2,PRKAR2B,PRKACA,YWHAE,PACRG,ANAPC2
    NOT actin filament binding MAP1S,UXT
    protein binding C14orf135,GABRG2,LINC00482,VPS18,GEMIN7,KLK6,HELLS,KLF11,IKBIP,CWC15
    single-stranded DNA binding MCM7,DMC1,SWSAP1,ERCC1,TDP2B,MEIOB,NME2,PEO1,HNRNPK,MCM4
    RNA binding DKC1,AGFG1A,EIF4E2RS1,RPP14,AHCYL1,ARHGEF28,FUS,TUT1,CNP,RBM17
    microtubule binding JAKMIP1,DPYSL2B,KIF17,CENPE,CKAP5,DPYSL5,MAPT,CETN1,CEP350,MID2

    Interacting Protein

    LRPPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPPRC.

    MYC;EIF4E;SLIRP;PPARGC1A;vpu;7242199;Ppargc1a

    Resources

    References

    • Baggio, F; Bratic, A; et al. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. NUCLEIC ACIDS RESEARCH 42:13920-13938(2014).
    • Zhou, JY; Zhang, FH; et al. Downregulation of LRPPRC Induces Apoptosis in Prostate Cancer Cells Through the Mitochondria-Mediated Pathway. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 29:345-350(2014).

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