| Description : |
This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
157.7 kDa |
| AA Sequence : |
MAALLRSARWLLRAGAAPRLPLSLR LLPGGPGRLHAASYLPAARAGPVAG GLLSPARLYAIAAKEKDIQEESTFS SRKISNQFDWALMRLDLSVRRTGRI PKKLLQKVFNDTCRSGGLGGSHALL LLRSCGSLLPELKLEERTEFAHRIW DTLQKLGAVYDVSHYNALLKVYLQN EYKFSPTDFLAKMEEANIQPNRVTY QRLIASYCNVGDIEGASKILGFMKT KDLPVTEAVFSALVTGHARAGDMEN AENILTVMRDAGIEPGPDTYLALLN AYAEKGDIDHVKQTLEKVEKSELHL MDRDLLQIIFSFSKAGYPQYVSEIL EKVTCERRYIPDAMNLILLLVTEKL EDVALQILLACPVSKEDGPSVFGSF FLQHCVTMNTPVEKLTDYCKKLKEV QMHSFPLQFTLHCALLANKTDLAKA LMKAVKEEGFPIRPHYFWPLLVGRR KEKNVQGIIEILKGMQELGVHPDQE TYTDYVIPCFDSVNSARAILQENGC LSDSDMFSQAGLRSEAANGNLDFVL SFLKSNTLPISLQSIRSSLLLGFRR SMNINLWSEITELLYKDGRYCQEPR GPTEAVGYFLYNLIDSMSDSEVQAK EEHLRQYFHQLEKMNVKIPENIYRG IRNLLESYHVPELIKDAHLLVESKN LDFQKTVQLTSSELESTLETLKAEN QPIRDVLKQLILVLCSEENMQKALE LKAKYESDMVTGGYAALINLCCRHD KVEDALNLKEEFDRLDSSAVLDTGK YVGLVRVLAKHGKLQDAINILKEMK EKDVLIKDTTALSFFHMLNGAALRG EIETVKQLHEAIVTLGLAEPSTNIS FPLVTVHLEKGDLSTALEVAIDCYE KYKVLPRIHDVLCKLVEKGETDLIQ KAMDFVSQEQGEMVMLYDLFFAFLQ TGNYKEAKKIIETPGIRARSARLQW FCDRCVANNQVETLEKLVELTQKLF ECDRDQMYYNLLKLYKINGDWQRAD AVWNKIQEENVIPREKTLRLLAEIL REGNQEVPFDVPELWYEDEKHSLNS SSASTTEPDFQKDILIACRLNQKKG AYDIFLNAKEQNIVFNAETYSNLIK LLMSEDYFTQAMEVKAFAETHIKGF TLNDAANSRLIITQVRRDYLKEAVT TLKTVLDQQQTPSRLAVTRVIQALA MKGDVENIEVVQKMLNGLEDSIGLS KMVFINNIALAQIKNNNIDAAIENI ENMLTSENKVIEPQYFGLAYLFRKV IEEQLEPAVEKISIMAERLANQFAI YKPVTDFFLQLVDAGKVDDARALLQ RCGAIAEQTPILLLFLLRNSRKQGK ASTVKSVLELIPELNEKEEAYNSLM KSYVSEKDVTSAKALYEHLTAKNTK LDDLFLKRYASLLKYAGEPVPFIEP PESFEFYAQQLRKLRENSSTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
