ltc4s
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  • Official Full Name
  • leukotriene C4 synthase
  • Background
  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.
  • Synonyms
  • LTC4S; leukotriene C4 synthase; MGC33147; Leukotriene C(4) synthase; LTC4 synthase; OTTHUMP00000197039
Cat.#:LTC4S-1225HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LTC4S Protein, MYC/DDK-tagged
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Cat.#:LTC4S-4588HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LTC4S Protein, GST-tagged
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Cat.#:LTC4S-923HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LTC4S, His tagged
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Cat.#:LTC4S-9352MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LTC4S Protein
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Cat.#:LTC4S-3502RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LTC4S Protein
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Cat.#:LTC4S-668HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LTC4S cell lysate
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Involved Pathway

LTC4S involved in several pathways and played different roles in them. We selected most pathways LTC4S participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTC4S were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP1A2; PTGDSB; PLA2G4D; GPX6; PLA2G4A; CYP4F14; CYP4B1; CYP2P9; MAPKAPK2B; ALOX15
Metabolic pathways
CYP3A7-CYP3AP1; CYP3A7; ALPP; AGPHD1; B3GNT5B; CYP2P6; EARS2; POLR3D; GLULC; ACOX3

Protein Function

LTC4S has several biochemical functions, for example, enzyme activator activity, glutathione binding, glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LTC4S itself. We selected most functions LTC4S had, and list some proteins which have the same functions with LTC4S. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme activator activity
Related Protein SAE1; TRIM23; PRKCD; GMFG; CTSA; DAOA; PSAP; ALOX5AP; HSPB2; CASP9
Function glutathione binding
Related Protein GSTM7; GSTM4; GSTM3; MGST1; GSS; PTGESL; PTGES; GSTM2; GPX1; LTC4S
Function glutathione peroxidase activity
Related Protein GPX8; GSTZ1; CLIC2; GPX3; MGST1; GSTK1; GPX4B; GPX5; GPX4A; MGST3
Function glutathione transferase activity
Related Protein EEF1E1; EEF1G; GSTA; GSTT1; GSTO2; HPGDS; GSTM5; GSTT2B; GSTO1; GSTM7
Function leukotriene-C4 synthase activity
Related Protein LTC4S; MGST2
Function lipid binding
Related Protein SEC14L3; FAM123A; PITPNM2; AP2M1A; RBP2A; TRIP10A; BPIFB4; FABP11A; PFN4; PITPNB
Function protein binding
Related Protein OAS1A; PUF60; SLMAP; WDR61; UBA7; KIF1B; HMMR; C19orf46; SFN; GAK
Function protein heterodimerization activity
Related Protein PAFAH1B3; THRA; PDZD7; BCL2L2; SLC51A; AXL; IKBKG; TTR; PRMT5; JAM2A

LTC4S Related Articles

Boger, PC; Shutt, JD; et al. Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma. HISTOPATHOLOGY 61:509-517(2012).
Queto, T; Gaspar-Elsas, MI; et al. Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. JOURNAL OF LEUKOCYTE BIOLOGY 87:885-893(2010).