Recombinant Human LTC4S protein(Met1-Ala150), His-tagged

• Cat.No.: LTC4S-923H
• Product Overview: Recombinant Human LTC4S (NP_665874.1) (Met 1-Ala 150) was expressed in Insect Cells, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: Insect Cells
• Species: Human
• Tag: His
• Protein length: Met1-Ala150
• Form: Lyophilized from sterile 50mM Hepes, 0.1% Triton 0.5% DOC, 10% Gly, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human LTC4S consists of 156 amino acids and predicts a molecular mass of 17 kDa as estimated in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: LTC4S leukotriene C4 synthase [ Homo sapiens ]
• Official Symbol: LTC4S
• Synonyms: LTC4S; leukotriene C4 synthase; MGC33147; LTC4 synthase
• Gene ID: 4056
• mRNA Refseq: NM_145867
• Protein Refseq: NP_665874
• MIM: 246530
• UniProt ID: Q16873

Reviews

10/10/2021

The LTC4S Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.

01/25/2021

Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.

07/02/2016

In addition to its remarkable quality and exceptional technical support, the LTC4S Protein boasts an impressive range of applications.

Q&As

How does LTC4S protein contribute to inflammation?

LTC4S protein catalyzes the conversion of arachidonic acid to leukotriene C4, which contributes to the inflammatory response in conditions such as asthma and allergic reactions.

How is LTC4S protein expression levels associated with asthma severity?

Studies have shown that increased expression of LTC4S protein is associated with more severe asthma symptoms and poor response to standard asthma medications.

What are the genetic variations of LTC4S protein associated with?

Genetic variations in the LTC4S gene have been associated with increased susceptibility to asthma and other inflammatory diseases.

Are there any drugs targeting LTC4S protein currently available?

Yes, there are drugs targeting LTC4S protein, such as leukotriene modifiers, which are used to manage asthma and allergic rhinitis.

Can LTC4S protein be a biomarker for asthma?

LTC4S protein levels in blood or sputum samples have been investigated as potential biomarkers for asthma severity and response to treatment.