MAP2K7 Protein, MAP2K7 mitogen-activated protein kinase kinase 7


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Official Full Name MAP2K7 mitogen-activated protein kinase kinase 7
Background The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
Synonyms MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
    Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
    Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7
    Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7
    Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
    Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
    Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His

    MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF1A; HRASB; RAP1B; FGF13A; RASA1; RPS6KA3B; JUND; MKNK2B; TGFB2; PAK2B
    ErbB signaling pathway ERBB3; PIK3CA; SHC1; MYCB; RAF1; AKT1; BTC; RAF1A; CBL; HBEGFA
    Protein processing in endoplasmic reticulum HSC70; HSPA2; SSR3; RAD23AA; DNAJC5GA; SEC24B; NFE2L2; HSP70L; P4HB; UBXN6
    Osteoclast differentiation SPI1; SIRPG; IFNAR2; NFKBIA; IL1B; RAC1; SIRPB1; FCGR4; PIK3CA; PIK3CG
    Toll-like receptor signaling pathway CCL3; TLR7; MAP2K2B; CD86; TOLLIP; FADD; IL1B; CCL5; TLR4; AKT2L
    T cell receptor signaling pathway MAP2K1; PIK3R1; NFATC3; HRAS; NFATC1; MAPK9; CD8B; PPP3R1; NCK2; OXSR1A
    Fc epsilon RI signaling pathway MAP2K3; MAPK1; BTK; LCP2; RAC2; FCER1A; PLA2G4B; PLA2G4C; MAPK12; IL3
    TNF signaling pathway MAPK9; CXCL10; MAP2K6; TAB2; MAP2K3; MAPK8; CASP10; MAPK1; TNF; MAP2K1
    Neurotrophin signaling pathway NGF; NGFRAP1; NGFR; MAP3K5; PSEN1; GSK3B; CDC42; MAPK10; PLCG1; PIK3R2
    GnRH signaling pathway MAP3K1; MAPK13; GNA15.4; PLA2G4D; PTK2BB; MAPK3; HRAS; GNRH2; CACNA1SB; FSHB
    Influenza A Ifna15; IFNAR1; SLC25A6; IFNA16; NXT2; RAE1; CXCL10; NUP98; DNAJB1; XPO1
    Epstein-Barr virus infection PIK3CA; HSPA1B; GTF2E2; POLR2G; PSMD13; TRAF6; PIK3CD; PSMC2; CD44; TBPL1

    MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activity ALPK2; MAP3K14; MAP3K9; SBK3; MAP2K2A; MAP2K1; MAPK14; MAP3K20; MAPK10; MAP2K2B
    enzyme binding PLAUR; H2AFX; MLEC; SRC; APBA3; CCDC99; PPP3CB; SPDL1; NOTCH3; HLCS
    magnesium ion binding MAPK12; TSSK6; PRPSAP1; PPA1; PRPS1A; TSSK4; FEN1; MTHFD2; ATP11C; PI4K2A
    protein binding RPS3; P2RY6; HMGB4; ANO6; WNT2; NOTCH1; SP4; PARP9; ZBTB1; MCM4
    protein kinase binding THY1; MVP; CDH2; BAG5; FZD5; MSN; AP2A2; CD3E; CADPS; CRY1
    protein phosphatase binding KAT2A; LCK; JUP; FLT4; TP53; CSF1R; RPA2; VCAN; CDH2; PPARG
    protein serine/threonine kinase activity RPS6KB1B; ALPK1; PRKCQ; BRAF; ICK; TAOK1; PIK3R4; BMP2K; Aatk; OXSR1B
    protein tyrosine kinase activity DYRK2; FGFR1A; EPHA4A; CLK2; MAP3K9; MAP2K5; EGFRA; FYNA; FGFR2; DSTYK

    MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

    MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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